Artemether

An artemisinin derivative that is used in the treatment of MALARIA.

Also Known As:

Artemether, (3R-(3alpha,5abeta,6alpha,8abeta,9alpha,10beta,12beta,12aR*))-isomer; Artemether, (3R-(3alpha,5abeta,6beta,8aalpha,9alpha,10beta,12beta,12aR*))-isomer; Artemether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; Artenam; O-Methyldihydroartemisinine; alpha-Artemether; beta-Arthemeter; O Methyldihydroartemisinine; alpha Artemether; beta Arthemeter; 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-

Networked: 493 relevant articles (102 outcomes, 115 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Utzinger, Jürg: 15 articles (09/2011 - 01/2002)
2.	Tanner, Marcel: 13 articles (06/2016 - 01/2002)
3.	White, Nicholas J: 10 articles (01/2018 - 12/2003)
4.	Davis, Timothy M E: 9 articles (01/2022 - 03/2006)
5.	Keiser, Jennifer: 8 articles (09/2011 - 02/2006)
6.	Chollet, Jacques: 8 articles (12/2006 - 01/2002)
7.	Tanner, M: 7 articles (12/2001 - 03/2000)
8.	Han, Pengxun: 6 articles (03/2022 - 01/2019)
9.	Shao, Mumin: 6 articles (03/2022 - 01/2019)
10.	Sun, Huili: 6 articles (03/2022 - 01/2019)

Related Diseases

1.	Malaria 03/09/2018 - "Children whose caregivers considered artemether the best treatment against malaria were five times more likely to be treated with artemether than children with caregivers who did not consider it the best (OR 5.07, 95% CI 2.93-8.78). " 01/01/2006 - "Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. " 10/01/2008 - "Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria." 10/01/1999 - "Artemether is a new and effective treatment for malaria, although relapse is a problem in monotherapy. " 11/01/1996 - "artemether would be an effective treatment of severe malaria in the rural tropics in situations where oral or parenteral administration is not possible."
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 11/21/1992 - "Artemether is effective against falciparum malaria but associated with a high recrudescence rate. " 07/01/1997 - "These results suggest that artemether is rapidly effective in acute recrudescent Plasmodium falciparum malaria and is without deleterious side effects." 11/01/2015 - "Efficacy of a novel sublingual spray formulation of artemether in African children with Plasmodium falciparum malaria." 09/01/1999 - "An open study to evaluate the efficacy of artemether in severe falciparum malaria." 01/01/2008 - "[Efficacy of artemether in the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6-60 months of age in Bangui (Central African Republic)]."
3.	Cerebral Malaria 01/01/2023 - "Previous work in murine experimental cerebral malaria (ECM) indicated that the combination of artemether plus intraperitoneal whole blood improved vascular integrity and increased survival compared to artemether alone. " 05/01/1997 - "The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study." 02/12/2005 - "Rectal artemether is effective and well tolerated and could be used as treatment for cerebral malaria." 05/01/1997 - "The disposition of intramuscular artemether (AM) was studied in 26 Kenyan children with cerebral malaria. " 03/01/1996 - "The clinical efficacy of intramuscular artemether was studied in 144 children suffering from severe non cerebral malaria. "
4.	Infections 11/18/2023 - "The efficacy of artemether was the same when administered early or late in the infection. " 01/01/2003 - "These findings have been confirmed in clinical trials for the former two parasites; administered orally once every 2-3 weeks, artemether significantly reduced the incidence and intensity of patent infections. " 01/01/2003 - "Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections." 05/01/2002 - "Randomized controlled clinical trials confirmed that artemether, orally administered at a dose of 6 mg/kg once every 2-3 weeks, results in no drug-related adverse effects, and significantly reduces the incidence and intensity of schistosome infections. " 01/01/1998 - "To study the effect of artemether (Art) for prevention of schistosomal infection. "
5.	Schistosomiasis (Bilharziasis) 03/01/1982 - "[Studies on the efficacy of artemether in experimental schistosomiasis (author's transl)]." 08/01/2000 - "These results provide a basis for clinical trials in humans, for further assessment of the potential of artemether for schistosomiasis control." 03/01/2000 - "In this article, Xiao Shuhua, Mark Booth and Marcel Tanner review the results of laboratory tests and field trials of artemether against schistosomiasis in China." 01/01/2003 - "These findings enlarge the scope and potential of artemether and further contribute to discussions of its role as an additional tool for integrated schistosomiasis control." 05/01/2002 - "In conclusion, artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings."

Related Drugs and Biologics

1.	Artesunate
2.	Quinine (Quinson)
3.	Lumefantrine
4.	artemisinin (artemisinine)
5.	Mefloquine (Lariam)
6.	Chloroquine (Aralen)
7.	Antimalarials (Antimalarial Agents)
8.	Lumefantrine Drug Combination Artemether (Coartem)
9.	artemotil (arteether)
10.	pyrimethamine drug combination fanasil (Fansidar)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Chemoprevention