An open clinical trial was conducted in 30 patients of severe
falciparum malaria with heavy parasitaemia (parasitized erythrocytes above 5%).
Artemether (methyl
ether of
dihydroartemisinin-active principle isolated from Chinese plant
Qinghaosu) was administered as 80 mg
intramuscular injection twice on first day and then single dose of 80 mg intramuscular on 2nd to 5th day. The trial could be completed in 28 patients and two patients expired. In our observation
falciparum malaria affected the young adults in their most productive period of life i.e. 25-44 yrs. All patients became afebrile by the 4th day with
fever clearance time approximately 31.92 +/- 15.30 hr. Twenty-five patients (83.33%) became parasite free by 5th day with mean parasite clearance time approximately 47.04 +/- 19.95 hr. Deranged liver function and renal profile was observed in 63% and 50% patients respectively. Two patients, who died had very high degree of parasitaemia (50% and 16%) with
cerebral malaria. One died due to multiorgan failure and other due to massive
hematemesis and
shock. The type of response achieved by
artemether therapy was analysed as per WHO criteria suggested for
chloroquine resistance. S response was observed in 25 patients (cure rate 83.33%). Two patients (6.66%) patients showed R II response, one patient (3.33%) showed R III response and R I response was not observed in any patient. No significant side effects were noted. This pilot study demonstrated that intramuscular
artemether is a useful addition to
antimalarial drugs in this era of multidrug resistant P.
falciparum malaria showing high clinical potency with virtually no side effect.