Artemisinins

01/01/2017 - "Artemisinins are still highly efficacious in large malaria-endemic regions though declining efficacy has occurred in Southeast Asia. "
11/01/2007 - "Artemisinins are natural products that show potent and selective activity against parasites, making them useful for the treatment of malaria. "
10/31/2021 - "IMPORTANCE This work reports a new chemical structure that (i) displays activity against the human malaria parasite Plasmodium falciparum at 3 stages of the parasitic cycle (blood stage, hepatic stage, and sexual stages), (ii) remains active against parasites that are resistant to the first-line treatment recommended by the World Health Organization (WHO) for the treatment of severe malaria (artemisinins), and (iii) reduces transmission of the parasite to the mosquito vector in a mouse model. "
05/09/2015 - "However, confirmed resistance to artemisinins in South-East Asia, and reports of reduced efficacy of ACTs raise major concerns for malaria treatment and control. "
12/26/2019 - "Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. "

01/01/2023 - "Artemisinins can induce a temporary non-replicative or 'dormant' drug refractory state in Plasmodium falciparum malaria parasites which may explain recrudescences observed in clinical trials despite full drug susceptibility, but whether it explains the dosing-response relationship is uncertain. "
01/01/2020 - "Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. "
01/01/2016 - "The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. "
01/01/2015 - "CONTEXTS: Artemisinins and its derivatives are considered the basis in the treatment of Plasmodium falciparum malaria due to their high potency and rapid action. "
07/08/2008 - "A concern was raised about the resistance to artemisinins of falciparum malaria in the country. "

01/01/2020 - "Progressively, research has found that artemisinins displayed multiple pharmacological actions against inflammation, viral infections, and cell and tumour proliferation, making it effective against diseases. "
01/01/2022 - "Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand."
01/01/2022 - "However, recent studies also indicate the potential for artemisinin and related compounds, commonly referred to as artemisinins, in combating viral infections, inflammation and certain cancers. "
01/01/2019 - "Evidence has accumulated during the past few years which demonstrated the protective effects of artemisinin and its derivatives (artemisinins) in several other diseases beyond malaria, including cancers, autoimmune disorders, inflammatory diseases, viral and other parasite-related infections. "

08/01/2018 - "More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. "
01/01/2017 - "Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. "
03/01/2015 - "However, the ability of artemisinins to kill cancer cells through a variety of molecular mechanisms has been explored. "
12/01/2013 - "These results provide a deeper understanding of the molecular mechanisms of action of artemisinins and will contribute to the development and application of this class of compounds in cancer treatment. "
01/01/2012 - "In xenograft models, exposure to artemisinins substantially reduces tumor volume and progression. "

01/01/2018 - "Artemisinins have been reported to have diverse functions, such as antimalaria, anticancer, anti-inflammation, and immunoregulation activities. "
01/11/2011 - "Toxicokinetic studies showed oil-soluble artemisinins form a depot at the intramuscular injection sites, which is associated with fascia inflammation in muscles. "
01/01/2020 - "Progressively, research has found that artemisinins displayed multiple pharmacological actions against inflammation, viral infections, and cell and tumour proliferation, making it effective against diseases. "
01/01/2020 - "These studies revealed the ability of artemisinins in attenuating proliferation, inflammation, invasion, and metastasis, and in inducing apoptosis. "
04/01/2014 - "Artemisinins have been evaluated in animal models of autoimmune diseases, allergic disorders and septic inflammation. "