Zona Pellucida Glycoproteins

Membrane glycoproteins that constitute the ZONA PELLUCIDA in mammals and function in the recognition and binding of SPERMATOZOA.

Also Known As:

Sperm Receptors; ZP Proteins; Zona Pellucida Glycoprotein-1; Zona Pellucida Glycoprotein-2; Zona Pellucida Glycoprotein-3; Glycoprotein-1, Zona Pellucida; Glycoprotein-2, Zona Pellucida; Glycoprotein-3, Zona Pellucida; Glycoproteins, Zona Pellucida; Pellucida Glycoprotein-1, Zona; Pellucida Glycoprotein-2, Zona; Pellucida Glycoprotein-3, Zona; Pellucida Glycoproteins, Zona; Proteins, ZP; Receptors, Sperm; Zona Pellucida Glycoprotein 1; Zona Pellucida Glycoprotein 2; Zona Pellucida Glycoprotein 3

Networked: 35 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gupta, Satish K: 3 articles (03/2011 - 12/2005)
2.	Chrusciel, Marcin: 2 articles (01/2022 - 03/2014)
3.	Huhtaniemi, Ilpo: 2 articles (01/2022 - 03/2014)
4.	Li, Xiangdong: 2 articles (01/2022 - 03/2014)
5.	Rahman, Nafis A: 2 articles (01/2022 - 03/2014)
6.	Wassarman, Paul M: 2 articles (01/2022 - 05/2002)
7.	Bernaczyk, Piotr: 1 article (01/2022)
8.	Coelingh Bennink, Herjan J T: 1 article (01/2022)
9.	Guo, Peilan: 1 article (01/2022)
10.	Lebiedzinska, Weronika: 1 article (01/2022)

Related Diseases

1.	Infertility (Sterility) 01/01/2008 - "From a clinical point of view, an observed lack or weak expression of some sperm receptors to ZP3 in cases of idiopathic infertility associated with in vitro fertilization failure suggests that knowing the molecular mechanism driving the gamete recognition can be important at the diagnostic level. " 09/01/2000 - "Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. " 01/01/1998 - "Infertility in mice induced by a recombinant ectromelia virus expressing mouse zona pellucida glycoprotein 3." 04/01/1991 - "Relatedness to other mammalian sperm receptors and identification of the genes involved would provide valuable information to our understanding of fertilization and to the problems of infertility and contraception." 03/01/2011 - "Nonetheless, contraceptive vaccines based on ZP proteins have shown very promising results in controlling wildlife population such as wild horses, white-tailed deers, elephants, marsupials, grey seals and dogs, where long term infertility or even permanent sterility is desirable."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2023 - "The study aims to explore the prognostic significance of zona pellucida glycoprotein 3 (ZP3) in hepatocellular carcinoma (HCC) tissues. "
3.	Herpes Zoster 06/30/2011 - "Our results suggest that some of the most frequent zona anomalies may be at least partly explained by sequence variations in genes expressing the four human ZP proteins, especially those in ZP2 and ZP3." 01/01/2009 - "First, a pilot study using porcine zona pellucidae (PZP) demonstrated that ZP proteins, primarily the ZP3 component of PZP, are highly immunogenic in the grey kangaroo and produce a long-lasting humoral response to a single immunisation, as found in other marsupials. " 05/01/2008 - "A detailed mapping of single mammalian ZP proteins and their relationship within the supramolecular architecture of the zona matrix would clearly supply insights into the molecular basis of sperm-egg recognition. " 05/01/2008 - "In dog, cattle and, putatively, pig, cat, and rabbit, the zona is composed of three ZP proteins (ZPA/ZP2, ZPB/ZP4, and ZPC/ZP3). " 01/01/2003 - "A reduction in the number of incompletely acrosome-reacted spermatozoa, which can bind tightly to the zona pellucida and mask free sperm receptors of the zona pellucida, could reduce the incidence of polyspermic penetration; however, morphological differences in the reaction of the zona pellucida have been observed between IVM and ovulated oocytes, which suggests that altered zona morphology may be another cause of polyspermic penetration. "
4.	Oophoritis 03/01/2011 - "To avoid oophoritis, immunogens corresponding to mapped B cell epitopes of ZP proteins that are devoid of 'oophoritogenic' T cell epitopes have been proposed. " 12/01/2005 - "Vaccines based on ZP proteins are quite efficacious in producing contraceptive effects, but may induce oophoritis, affecting sex steroids. "
5.	Female Infertility 10/20/2023 - "Recently, numerous mutations in genes encoding ZP proteins have been shown to be possibly related to oocyte abnormality and female infertility; few reports have confirmed the functions of these mutations in living animal models. " 01/01/2022 - "In the absence of a ZP, due to inactivation or mutation of genes encoding ZP proteins, there is a loss of contacts between growing oocytes and neighboring follicle cells and a concomitant reduction in the production of ovulated eggs that results in female infertility."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Contraceptive Vaccines
3.	Proteins (Proteins, Gene)
4.	Vaccines
5.	Glycoproteins (Glycoprotein)
6.	Contraceptive Agents (Contraceptives)
7.	Proteasome Endopeptidase Complex (Proteasome)
8.	B-Lymphocyte Epitopes (B-Cell Epitope)
9.	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)
10.	Interleukin-1 Receptors (Interleukin 1 Receptor)

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Female Contraceptive Devices (Vaginal Ring)
3.	Immunologic Contraception (Immunocontraception)