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cyclic des-acyl ghrelin (6-13)

Also Known As:

AZP531; cyclci DAG(6-13)

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - cyclic des-acyl ghrelin (6-13): 3
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Ghrelin: 5030
      - cyclic des-acyl ghrelin (6-13): 3

Experts

1.	Abribat, Thierry: 2 articles (04/2013 - 11/2012)
2.	Delhanty, Patric J D: 2 articles (04/2013 - 11/2012)
3.	Baell, Jonathan: 1 article (03/2014)
4.	Ban, Kung: 1 article (03/2014)
5.	Brock, James A: 1 article (03/2014)
6.	Callaghan, Brid: 1 article (03/2014)
7.	Ferens, Dorota: 1 article (03/2014)
8.	Furness, John B: 1 article (03/2014)
9.	Kosari, Samin: 1 article (03/2014)
10.	Nguyen, Trung V: 1 article (03/2014)

Related Diseases

1.	Glucose Intolerance 04/01/2013 - "C57BL/6J mice were infused with saline, DAG, or AZP531 continuously for 4 wk, and fed either normal diet (ND) or normal diet for 2 wk followed by a high-fat diet (HFD) for 2 wk. Compared with mice in the ND group, HFD increased body and fat mass, caused glucose intolerance and insulin resistance, had proinflammatory effects in white adipose tissue, and caused lipid accumulation in brown adipose tissue. "
2.	Prediabetic State (Prediabetes) 04/01/2013 - "A murine model of prediabetes was used to assess possible mechanisms of action for DAG and a newly developed bioactive analog, AZP531. "
3.	Insulin Resistance 04/01/2013 - "C57BL/6J mice were infused with saline, DAG, or AZP531 continuously for 4 wk, and fed either normal diet (ND) or normal diet for 2 wk followed by a high-fat diet (HFD) for 2 wk. Compared with mice in the ND group, HFD increased body and fat mass, caused glucose intolerance and insulin resistance, had proinflammatory effects in white adipose tissue, and caused lipid accumulation in brown adipose tissue. "
4.	Hypotension (Low Blood Pressure) 03/01/2014 - "The rapid hypotension was not mimicked by ghrelin, unacylated ghrelin or the unacylated ghrelin receptor agonist, AZP531. "
5.	Type 2 Diabetes Mellitus (MODY) 11/20/2012 - "Taken together these results support the rationale for developing AZP531 as a long-acting UAG analogue for subcutaneous injection for the treatment of type 2 diabetes mellitus and other metabolic disorders."

Related Drugs and Biologics

1.	Ghrelin Receptors
2.	Ghrelin
3.	Lipids

Related Therapies and Procedures

1.	Subcutaneous Injections