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SH-053-2'F-R-CH3

an agonist of GABA-A alpha5 subunit; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - SH-053-2'F-R-CH3: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        Diazepam: 4432
        SH-053-2'F-R-CH3: 3

Experts

1.	Cook, James M: 2 articles (01/2022 - 01/2015)
2.	Braga, Matheus Silva: 1 article (01/2022)
3.	Cortez, Isadora L: 1 article (01/2022)
4.	Del-Bel, Elaine A: 1 article (01/2022)
5.	Domingos, Luana B: 1 article (01/2022)
6.	Gomes, Felipe V: 1 article (01/2022)
7.	Guimarães, Francisco S: 1 article (01/2022)
8.	Li, Guanguan: 1 article (01/2022)
9.	Mian, Md Yeunus: 1 article (01/2022)
10.	Pedrazzi, João Francisco C: 1 article (01/2022)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2015 - "In addition, a chiral positive allosteric modulator (PAM), SH-053-2'F-R-CH3 (2), has been shown to reverse the deleterious effects in the MAM-model of schizophrenia as well as alleviate constriction in airway smooth muscle. "
2.	Mental Disorders (Mental Disorder) 01/01/2022 - "These findings suggest that GL-II-73 and SH-053-2'F-R-CH3 cause distinct sex-dependent behavioral responses and support continued preclinical research on the potential of positive allosteric modulators of α5-GABAAR for the treatment of psychiatric disorders."
3.	Autistic Disorder (Autism) 08/26/2023 - "Here, we investigated whether the positive allosteric modulator of α5-containing GABA A receptors (α5-GABA A Rs) SH-053-2'F-R-CH3 (10 mg/kg) attenuates behavioral abnormalities in a rat model for autism based on in utero VPA exposure. "

Related Drugs and Biologics

1.	GABA-A Receptors (GABA(A) Receptor)
2.	gamma-Aminobutyric Acid (GABA)