Imidazoles

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

Networked: 107 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Biersack, Bernhard: 3 articles (06/2015 - 09/2010)
2.	Schobert, Rainer: 3 articles (06/2015 - 09/2010)
3.	Mueller, Thomas: 2 articles (06/2015 - 09/2010)
4.	Jain, Rahul: 2 articles (01/2005 - 09/2004)
5.	Guédon-Moreau, Laurence: 2 articles (02/2004 - 11/2003)
6.	Duc, Marie-Francoise: 2 articles (02/2004 - 11/2003)
7.	Ducrocq, Dominique: 2 articles (02/2004 - 11/2003)
8.	Quieureux, Yves: 2 articles (02/2004 - 11/2003)
9.	L'Hôte, Catherine: 2 articles (02/2004 - 11/2003)
10.	Caron, Jacques: 2 articles (02/2004 - 11/2003)

Related Diseases

1.	Infection 01/01/1986 - "The imidazoles in a cream vehicle are very effective for many infections and applied for 2-3 weeks they will clear most lesions. " 11/01/1998 - "Imidazoles are considered safe as topical therapy for fungal skin infections during pregnancy. " 01/01/1986 - "The imidazoles as a class are the treatment of choice for four dermatophyte infection syndromes. " 01/01/1985 - "Do the imidazoles have a role in the management of genitourinary fungal infections?" 07/01/1998 - "Newer medications in both oral and topical forms, including imidazoles and allylamines, have greatly increased the cure rate for tinea infections. "
2.	Rheumatoid Arthritis 05/01/1969 - "Urinary imidazoles in rheumatoid arthritis." 04/01/2008 - "Pyridinyl and pyrimidinyl imidazoles, selectively inhibit p38alpha MAP kinase, are useful in the treatment of inflammatory diseases like rheumatoid arthritis. " 07/05/2004 - "A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38alpha inhibitors and in vivo in several models of rheumatoid arthritis. "
3.	Sporotrichosis 04/01/1989 - "From the first report of the efficacy of the iodides for the treatment of sporotrichosis (1903) until the introduction of the imidazoles (azoles, 1960s), the number of antifungal agents available was very limited, including griseofulvin (1939), nystatin (1950), amphotericin B (1956), and flucytosine (1964). "
4.	Cutaneous Candidiasis 05/01/2001 - "KP-103 (1% solution) was highly effective as a treatment for guinea pigs with cutaneous candidiasis and achieved mycological eradication in 8 of the 10 infected animals, whereas none of the imidazoles tested (1% solutions) was effective in even reducing the levels of the infecting fungi. "
5.	Mycoses (Diseases, Fungus) 07/01/2001 - "Imidazoles are still widely used for the treatment of superficial mycoses and vaginal candidiasis. " 01/01/1991 - "imidazoles and in particular ketoconazole in treatment of severe affections of the eye such as mycoses is described. " 01/01/1987 - "The earliest antifungal imidazoles (kétoconazole and soon itraconazole) show a large activity spectrum and a good efficiency, especially in the deeply localized mycoses. " 03/01/1995 - "Itraconazole is a broad-spectrum oral triazole whose greatest advantages over the imidazoles are in its activity against aspergillosis and cryptococcosis, though it is also efficacious against the endemic deep mycoses. " 01/01/1994 - "The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses. "

Related Drugs and Biologics

1.	Antifungal Agents
2.	Nystatin (Mycostatin)
3.	Amphotericin B (Amphotericin)
4.	Azoles
5.	Flucytosine (Ancobon)
6.	Mitogen-Activated Protein Kinase 14
7.	Iodides
8.	Griseofulvin (Grifulvin V)
9.	KP 103
10.	Ketoconazole (Nizoral)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Therapeutics
4.	Oral Administration