Diazepam (Valium)

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

Also Known As:

Networked: 4044 relevant articles (363 outcomes, 423 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Parle, Milind: 11 articles (03/2012 - 10/2003)
2.	McDonough, John H: 7 articles (08/2015 - 04/2003)
3.	Huang, Tiao-Lai: 7 articles (11/2013 - 02/2005)
4.	Fidecka, Sylwia: 7 articles (01/2011 - 03/2002)
5.	Kulkarni, S K: 7 articles (09/2009 - 04/2000)
6.	Löscher, Wolfgang: 6 articles (08/2015 - 10/2002)
7.	Guidotti, Alessandro: 6 articles (12/2011 - 03/2004)
8.	Auta, James: 6 articles (12/2011 - 03/2004)
9.	Saraf, Manish Kumar: 6 articles (01/2011 - 08/2007)
10.	Anand, Akshay: 6 articles (01/2011 - 08/2007)

Related Diseases

1.	Seizures (Seizure) 05/01/1989 - "Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%. " 03/01/1984 - "Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and was highly effective in preventing recurrent fits within a 24 h observation period (p less than 0.001). " 06/01/2013 - "Compounds 3f, 4c, 4f, 5k, 5p and 5w carrying active pharmacophores exhibited complete protection against seizure and their results were comparable with standard drug diazepam. " 05/17/2011 - "Single dose pretreatment with AMFF (25 and 50mg/kg, i.p.) has found to be effective against both MES and PTZ-convulsions, but associated with a marked decrease in locomotor activity and motor activity performance (i.e., neurotoxic effects), similar to that of diazepam treatment. " 09/01/2014 - "Part 1 of this phase III study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter study of caregiver administered diazepam auto-injector (AI) in subjects with acute repetitive seizures (ARS) and demonstrated that diazepam AI was well-tolerated and significantly more effective than placebo AI in delaying the time to next seizure or rescue. "
2.	Status Epilepticus (Complex Partial Status Epilepticus) 03/01/2014 - "We sought to retrospectively evaluate the long-term efficacy of high-dose oral diazepam in reducing electrographic and clinical evidence of electrical status epilepticus during slow wave sleep in children. " 12/01/1984 - "Intravenous diazepam, used as the only therapy for status epilepticus, was effective in 58 of 78 episodes. " 04/01/1995 - "Diazepam is administered to children in status epilepticus by paramedics in many Emergency Medical Services systems throughout the United States despite the lack of clear evidence that this therapy is safe and effective when employed in the prehospital environment. " 01/01/1998 - "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus. " 02/01/2015 - "The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. "
3.	Febrile Seizures (Febrile Seizure) 07/01/2013 - "There was a significant reduction of recurrent febrile seizures with intermittent oral diazepam versus placebo with a relative risk (RR) of 0.67 (95% confidence interval (CI) 0.48 to 0.94) at 24 months), RR of 0.61 (95% CI 0.15 to 0.89) at 48 months, with no benefit at 6, 12 or 72 months. " 01/01/2012 - " was a significant reduction of recurrent febrile seizures with intermittent oral diazepam versus placebo with a relative risk (RR) of  0.67 (95% confidence interval (CI) 0.48 to 0.94) at 24 months), RR of 0.61 (95% CI 0.15 to 0.89) at 48 months, with no benefit at 6, 12 or 72 months. " 09/01/2000 - "However, diazepam used in the hospital was found to be effective in controlling acute febrile seizures." 03/01/2003 - "For children with prolonged or multiple febrile seizures, diazepam rectal gel (Diastat) is a safe and effective treatment. " 06/01/1996 - "We conclude that diazepam is a safe and effective drug for prophylaxis of febrile seizures when used as soon as any sign of illness appears. "
4.	Pain (Aches) 09/01/2011 - "Vaginal diazepam may be helpful in treating pelvic floor/urogenital pain conditions." 07/01/2010 - "Sexual pain as assessed on FSFI and serial VAS-P improved with diazepam (by 1.44 on 10-point scale, p = 0.14). " 08/01/2012 - "The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception. " 04/01/2012 - "In conclusion, the present study indicates that the NPS/NPSR system does not tonically control locomotion, sensitivity to diazepam, anxiety, depressive-like behaviours, memory and pain transmission in mice. " 08/19/2010 - "The pain-induced functional impairment in the rat (PIFIR) model was used to study the effects of diazepam on nociception. "
5.	Poisoning 01/01/2004 - "These studies show that diazepam is an efficacious anticonvulsant in nerve agent poisoning. " 11/01/1975 - "Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning." 03/01/2004 - "Diazepam is the standard anticonvulsant used in the therapeutic management of OP poisoning. " 01/01/2004 - "In severe poisoning, diazepam administration should be considered even before these complications occur. " 01/01/2004 - "In instances of nerve agent poisoning during terrorist use in Japan, diazepam seems to have been an effective anticonvulsant. "

Related Drugs and Biologics

1.	Phenobarbital (Luminal)
2.	Midazolam (Versed)
3.	Benzodiazepines
4.	Phenytoin (Dilantin)
5.	Pentylenetetrazole (Metrazol)
6.	Valproic Acid (Valproate, Semisodium)
7.	Lorazepam (Ativan)
8.	Atropine (Hyoscyamine)
9.	Carbamazepine (Tegretol)
10.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Rectal Administration
2.	Premedication
3.	Drug Therapy (Chemotherapy)
4.	General Anesthesia
5.	Psychology Biofeedback (Biofeedback)