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N- (1- (4- (4- methoxybenzyl)- 5- phenethyl- 4H- 1,2,4- triazol- 3- yl)- 2- (1H- indol- 3- yl)ethyl)- 2- aminoacetamide

inhibits GMS-R1A, a ghrelin receptor

Also Known As:

JMV 2959; JMV-2959; JMV2959

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide: 3

Experts

1.	Chen, Mingzhu: 1 article (01/2021)
2.	Du, Xinyu: 1 article (01/2021)
3.	Zhao, Jing: 1 article (01/2021)
4.	Zhu, Shimin: 1 article (01/2021)
5.	Andreoli, María F: 1 article (01/2018)
6.	Cabral, Agustina: 1 article (01/2018)
7.	Epelbaum, Jacques: 1 article (01/2018)
8.	Fehrentz, Jean-Alain: 1 article (01/2018)
9.	Fernandez, Gimena: 1 article (01/2018)
10.	Labarthe, Alexandra: 1 article (01/2018)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 01/01/2021 - "We concluded that JMV2959 may be an effective candidate to treat drug addiction." 01/01/2021 - "A growth hormone secretagogue receptor 1 A antagonist, JMV2959, has been shown to reduce morphine-induced conditioned place preference (CPP) in rats within hours of intervention; thus, JMV2959 is a potential candidate for drug addiction treatment. "
2.	Hyperphagia (Overeating) 01/01/2018 - "Finally, fasting-induced hyperphagia of WT mice was significantly smaller in mice centrally treated with the GHSR inverse agonist K-(D-1-Nal)-FwLL-NH2, compared with mice treated with vehicle, whereas it was unaffected in mice centrally treated with the GHSR antagonists D-Lys3-growth hormone-releasing peptide 6 or JMV2959. "
3.	Anorexia 01/26/2012 - "By targeting the interaction between GHSR1a and DRD2 in wild-type mice with a highly selective GHSR1a antagonist (JMV2959) cabergoline-induced anorexia was blocked. "

Related Drugs and Biologics

1.	Ghrelin Receptors
2.	Peptides (Polypeptides)
3.	Morphine (MS Contin)
4.	Hormones (Hormone)
5.	Cabergoline
6.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)