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Autosomal Dominant 15 Deafness

Also Known As:

Deafness, Autosomal Dominant 15; DFNA15

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Hearing Loss (Hearing Impairment)
2.	Deafness (Deaf Mutism)
3.	Nonsyndromic Deafness

Experts

1.	Gao, Xia: 2 articles (01/2020 - 04/2014)
2.	Ma, Deng-Bin: 2 articles (01/2020 - 04/2014)
3.	Qian, Xiao-Yun: 2 articles (01/2020 - 04/2014)
4.	Zhou, Han: 2 articles (01/2020 - 04/2014)
5.	Zhu, Guang-Jie: 2 articles (01/2020 - 04/2014)
6.	Zhu, Min-Sheng: 2 articles (01/2020 - 04/2014)
7.	Chen, Huaqun: 1 article (01/2020)
8.	Chen, Xin: 1 article (01/2020)
9.	Fan, Chi: 1 article (01/2020)
10.	Gao, Xiang: 1 article (01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autosomal Dominant 15 Deafness:

1.	Transcription Factor Brn-3CIBA 01/01/2020 - "DFNA15, caused by mutations of the transcription factor POU4F3, is one of the most common forms of autosomal dominant non-syndromic deafness. " 02/01/2007 - "A dominant mutation of the gene encoding the POU4F3 transcription factor underlies human non-syndromic progressive hearing loss DFNA15. " 05/01/2000 - "To describe the detailed auditory phenotype of DFNA15, genetic hearing loss associated with a mutation in the POU4F3 transcription factor, and to define genotype-phenotype correlations, namely, how specific mutations lead to particular clinical consequences. "
2.	Transcription Factors (Transcription Factor)IBA 01/01/2017 - "A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. " 01/01/2014 - "POU4F3--a POU-domain transcription factor selectively expressed by these cells--has been shown to be essential for hair cell differentiation and survival in mice and its mutation in humans underlies late-onset progressive hearing loss (DFNA15). "
3.	Transcription Factor 3IBA 01/01/2018 - "Mutations in the POU class 4 transcription factor 3 (POU4F3) are known to cause autosomal dominant nonsyndromic hearing loss linked to the loci of DFNA15. "
4.	Orphan Nuclear ReceptorsIBA 01/01/2014 - "Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3."
5.	Proteins (Proteins, Gene)FDA Link 01/01/2008 - "The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. "
6.	DNA (Deoxyribonucleic Acid)IBA 04/01/2008 - "Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding."
7.	myosin VIIBA 04/01/2014 - "To explore the pathological mechanisms underlying the development of DFNA15, the effect of the mutation in Pou4f3 on the activity of the myosin VI (Myo6) promoter, was investigated. " 04/01/2014 - "The data suggests that mutated Pou4f3 has a negative role in the promoter activity of Myo6, and by extension, the expression of myosin VI, and this may be an underlying mechanism of DFNA15 hearing loss."