Abstract |
The POU4F3 transcription factor is expressed in the cochlear and vestibular hair cells of the inner ear and its targeted deletion results in a loss of inner ear hair cells. The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. Molecular modelling is utilised to propose a mechanism of stability enhancement, via an interaction between the truncated POU(HD) domain and the POU(S) domain of the transcription factor.
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Authors | Christopher M Frenz, Philippe P Lefebvre |
Journal | International journal of computational biology and drug design
(Int J Comput Biol Drug Des)
Vol. 1
Issue 3
Pg. 295-301
( 2008)
ISSN: 1756-0756 [Print] England |
PMID | 20054994
(Publication Type: Journal Article)
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Chemical References |
- Homeodomain Proteins
- POU4F3 protein, human
- Transcription Factor Brn-3C
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Topics |
- Computational Biology
- Computer Simulation
- Databases, Protein
- Half-Life
- Homeodomain Proteins
(chemistry, genetics, metabolism)
- Humans
- In Vitro Techniques
- Models, Molecular
- Protein Interaction Domains and Motifs
- Protein Stability
- Sequence Deletion
- Static Electricity
- Structural Homology, Protein
- Thermodynamics
- Transcription Factor Brn-3C
(chemistry, genetics, metabolism)
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