cytidine-5'-monophosphosialic acid

structure in first source

Also Known As:

CMP-Neu5Ac; cytidine-5'-monophospho-N-acetylneuraminic acid

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Cytosine Nucleotides: 10
        Cytidine Monophosphate: 1005
        cytidine-5'-monophosphosialic acid: 10
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Cytosine Nucleotides: 10
      - Cytidine Monophosphate: 1005
        cytidine-5'-monophosphosialic acid: 10
  - Pyrimidine Nucleotides: 48
    - Cytosine Nucleotides: 10
      - Cytidine Monophosphate: 1005
        cytidine-5'-monophosphosialic acid: 10
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Sugar Acids: 4
      - Neuraminic Acids: 8
        Sialic Acids: 594
        cytidine-5'-monophosphosialic acid: 10
  - Acyclic Acids
    - Sugar Acids: 4
      - Neuraminic Acids: 8
        Sialic Acids: 594
        cytidine-5'-monophosphosialic acid: 10
Carbohydrates: 22023
- Amino Sugars: 110
  - Neuraminic Acids: 8
    - Sialic Acids: 594
      - cytidine-5'-monophosphosialic acid: 10
- Sugar Acids: 4
  - Neuraminic Acids: 8
    - Sialic Acids: 594
      - cytidine-5'-monophosphosialic acid: 10

Experts

1.	Hinderlich, Stephan: 2 articles (07/2009 - 05/2005)
2.	Kim, Cheorl-Ho: 1 article (07/2020)
3.	Kwak, Choong-Hwan: 1 article (07/2020)
4.	Song, Kwon-Ho: 1 article (07/2020)
5.	DeOliveira, Rosane B: 1 article (10/2016)
6.	Gulati, Sunita: 1 article (10/2016)
7.	Lewis, Lisa A: 1 article (10/2016)
8.	Ram, Sanjay: 1 article (10/2016)
9.	Rice, Peter A: 1 article (10/2016)
10.	Shaughnessy, Jutamas: 1 article (10/2016)

Related Diseases

1.	Sialic Acid Storage Disease (Salla Disease) 03/16/2016 - "On the other hand, the CMP-Neu5Ac binding mode clearly elucidates why mutations in Arg263 and Arg266 can cause sialuria. " 05/24/2005 - "When sialuria-like mutant EK genes, in which the site for feedback regulation has been mutated, were used, CMP-Neu5Ac was synthesized at levels more than 4 times higher than that achieved with the wild-type EK and 2.5 times higher than that achieved with ManNAc feeding. " 07/01/2009 - "GNE is regulated by a variety of biochemical means, including tetramerization promoted by the substrate UDP-GlcNAc, phosphorylation by protein kinase C and feedback inhibition by CMP-Neu5Ac, which is defect in the human disease sialuria. " 06/01/1999 - "Sialuria, a disorder of sialic acid (NeuAc) metabolism characterized by increased free NeuAc in the cytoplasm of cells, is due to failure of CMP-Neu5Ac to feedback inhibit UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase. "
2.	Infections 01/01/2023 - "Interestingly, some peaks in the spectra of 1-81-S2 LOS after bacterial culture with CMP-Neu5Ac were consistent with disialylation of the LOS, which could be relevant to the reduced infectivity of FA1090 in men and could have implications regarding the phase variation of the LOS and the natural history of infection." 07/10/2020 - "N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens. " 10/01/2016 - "The second strategy utilized CMP-nonulosonate (CMP-NulO) analogs of sialic acid that were incorporated into LOS and prevented complement inhibition by physiologic CMP-Neu5Ac and resulted in attenuated gonococcal infection in mice. "
3.	Neoplasms (Cancer) 10/02/2013 - "We report here the development of chemoenzymatic methods for the large-scale synthesis of cancer-associated antigens globopentaose (Gb5), fucosyl-Gb5 (Globo H), and sialyl-Gb5 (SSEA4) by using overexpressed glycosyltransferases coupled with effective regeneration of sugar nucleotides, including UDP-Gal, UDP-GalNAc, GDP-Fuc, and CMP-Neu5Ac. "
4.	Glioma (Gliomas) 08/15/1991 - "We have studied the Gal beta 1-3GalNAc-R alpha 2,3 sialyltransferase from C6 glioma cells transferring Neu5Ac from CMP-Neu5Ac onto O-glycans of glycoproteins. "
5.	Breast Neoplasms (Breast Cancer) 11/01/2001 - "This reaction is mainly catalyzed by a CMP-Neu5Ac GalNAc alpha2,6-sialyltransferase: ST6GalNAc I. In order to generate STn-positive breast cancer cells, we have cloned a cDNA encoding the full-length human ST6GalNAc I from HT-29-MTX cells. "

Related Drugs and Biologics

1.	N-Acetylneuraminic Acid (Sialic Acid)
2.	Uridine Diphosphate (UDP)
3.	Sialyltransferases
4.	Complementary DNA (cDNA)
5.	Glycosyltransferases
6.	Protein Kinase C
7.	Polysaccharides (Glycans)
8.	Nucleotides
9.	Mixed Function Oxygenases (Monooxygenases)
10.	Guanosine Diphosphate (GDP)