N-Acetylneuraminic Acid (Sialic Acid)

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)

Also Known As:

Networked: 2473 relevant articles (43 outcomes, 274 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Varki, Ajit: 22 articles (11/2014 - 01/2003)
2.	Chrostek, Lech: 16 articles (11/2014 - 06/2004)
3.	Cylwik, Bogdan: 16 articles (11/2014 - 06/2004)
4.	Szmitkowski, Maciej: 15 articles (11/2014 - 06/2004)
5.	Nishino, Ichizo: 13 articles (09/2015 - 03/2004)
6.	Noguchi, Satoru: 12 articles (10/2014 - 03/2004)
7.	Gahl, William A: 11 articles (12/2014 - 07/2003)
8.	Reutter, Werner: 10 articles (11/2015 - 02/2002)
9.	Huizing, Marjan: 10 articles (12/2014 - 07/2003)
10.	Arnberg, Niklas: 9 articles (09/2015 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2012 - "Although cells from different tissues and organs responded to Ac(4)ManNAc treatment differently, treated cells with increased sialic acid contents showed dramatically reduced sensitivity (up to 130 times) to anti-cancer drugs as tested on various drugs with distinct chemical structures and acting mechanisms. " 01/01/2003 - "The total sialic acid content of the tumor tissue was significantly greater than that of the serum and not related to the concentration found in the serum. " 10/01/1984 - "Serum sialic acid was significantly greater in cancer patients than in normals. " 11/01/2015 - "This study investigated the response of nutrient-deprived cancer cells and their non-malignant counterparts to sialic acid supplementation and found that cells utilize negligible amounts of this sugar for energy. " 11/04/2014 - "For instance, previous studies have shown that the ratio of α2-3 to α2-6 linked sialic acid (SA) plays an important role in cancer biology. "
2.	Neoplasm Metastasis (Metastasis) 12/01/2011 - "Brain metastasis is characterized by many species having a reduced N-acetylneuraminic acid (Neu5Ac) content, however, modified by fucosylation or O-acetylation such as Fuc-GM4, Fuc-GM3, di-O-Ac-GM1, O-Ac-GM3. " 04/01/1992 - "The better differentiated cells had higher levels of sialyltransferase activity, which correlated with their higher levels of sialic acid and their enhanced ability to form liver metastases in the nude mouse following intrasplenic injection compared to the poorly differentiated cell lines. " 03/01/1990 - "Inhibition of sialic acid incorporation prevents hepatic metastases." 02/01/1986 - "These findings suggest that sialic acid on the cell surface may play a role in the metastasis of these cells. " 06/01/1985 - "A tumour model consisting of the highly metastatic mammary 13762 parental line, the non-metastatic and 6-thioguanine-resistant (TgR) variant line, and two TgR revertant lines (TgRrev, TgRrevM) that were occasionally metastatic, were used to determine whether the release of N-acetylneuraminic acid (NANA) was related to tumour metastasis. "
3.	Infection 10/01/2014 - "This study is designated to assess the effect of the severity of Babesia ovis infection on sialic acid concentration in blood sera in naturally infected sheep. " 12/01/2013 - "The presence of alpha-2, 3 and alpha-2, 6 sialic acid-linked receptors in the major organs examined in the present study suggests that each major organ may be affected by influenza virus infection. " 01/01/2012 - "Structural studies revealed how binding efficiency between the HA and sialic acid may alter the pandemic potential of infection. " 01/01/2011 - "The aims of this study were to determine the effect of sialic acid binding for the infection of cultured cells under unfavorable conditions, and comparison of TGEV strains and mutants, as well as the avian coronavirus IBV concerning their dependence on the sialic acid binding activity. " 06/01/2010 - "In our previous studies, experimental infection of breeder turkeys with A/turkey/Ohio/313053/04 resulted in drastic declines in egg production, and we confirmed high levels of virus replication and an abundant distribution of avian-specific alpha2,3 sialic acid-gal receptors in the oviduct of these turkeys. "
4.	Human Influenza (Influenza) 09/01/2015 - "In the present study, this interaction was demonstrated for SIV of both H1N1 and H3N2 subtypes as well as for human influenza viruses that recognize α2,6-linked sialic acid. " 01/01/2014 - "Subsequently, docking studies were done to find the binding mode of the sialic acid (SA) with influenza HA. " 05/01/2009 - "In the reported study, a wide range of complexes of influenza neuraminidases with inhibitor molecules (sialic acid derivatives and others) have been analyzed using charge densities from a transferable aspherical-atom data bank. " 03/01/2003 - "Although a role for these natural inhibitors in the innate anti-influenza immunity is still not clear, studies are in progress on the design of synthetic sialic acid-containing inhibitors of receptor binding which could be used as anti-influenza drugs." 07/09/2014 - "Our findings suggest that higher rates of disease during coinfection could stem from influenza-provided sialic acid, which increases pneumococcal proliferation, colonization, and aspiration."
5.	Leukemia 03/01/1987 - "Serial determinations revealed a rapid decline in the CSF sialic acid concentrations in the patients with CNS leukemia who responded well to the therapy and who were free from relapse of CNS leukemia. " 07/01/1986 - "Three patients with active leukemia had elevated sialic acid, but three patients whose leukemia was in remission had normal sialic acid levels. " 07/01/1995 - "In metabolic labelling experiments using the highly APO-1 positive cell lines HUT78 (adultT cell leukemia) and SKW6.4 (Blymphoblastoid cell line) APO-1 was characterised as a long living protein with a complex glycosylation pattern involving terminal sialic acid groups which account for 8-kDa of its apparent molecular weight on SDS-PAGE. " 07/13/1994 - "O-acetylated sialic acid as a distinct marker for differentiation between several leukemia erythrocytes." 07/01/1989 - "Human leukemia cells and mature lymphocytes induce platelet aggregation after removal of cell surface sialic acid."

Related Drugs and Biologics

1.	Neuraminidase (Sialidase)
2.	Glycoproteins (Glycoprotein)
3.	Orosomucoid (Seromucoid)
4.	Haptoglobins
5.	Transferases
6.	Fucose
7.	Proteins (Proteins, Gene)
8.	C-Reactive Protein
9.	Carbohydrates
10.	Antibodies

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Oral Hygiene (Dental Hygiene)
5.	Aftercare (After-Treatment)