Glycosyltransferases

Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.

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Networked: 242 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miyoshi, Eiji: 7 articles (05/2015 - 03/2006)
2.	Taniguchi, Naoyuki: 7 articles (01/2015 - 03/2006)
3.	Clausen, Henrik: 5 articles (02/2015 - 06/2003)
4.	Sugahara, Kazuyuki: 5 articles (01/2015 - 04/2002)
5.	Kitagawa, Hiroshi: 4 articles (03/2007 - 04/2002)
6.	Brockhausen, I: 4 articles (02/2007 - 02/2001)
7.	Muntoni, Francesco: 4 articles (03/2005 - 11/2002)
8.	Peracaula, Rosa: 3 articles (09/2015 - 04/2010)
9.	de Bolós, Carme: 3 articles (09/2015 - 11/2002)
10.	Takamatsu, Shinji: 3 articles (05/2015 - 04/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2004 - "Improved analytical tools for the study of glycosylation and application of molecular techniques for the characterisation of the genes encoding glycosyltransferases have, however, enabled the structural identification of some of the cancer-associated changes in glycosylation. " 11/15/1990 - "These studies further suggest that increased surface localization of certain glycosyltransferases with highly restricted in situ substrate specificities may be a common feature of highly metastatic tumor cells." 08/01/2015 - "Abnormal glycosylation is catalyzed by the specific glycosyltransferases and correlates with tumor cell apoptosis. " 01/01/2015 - "The enzyme activity of glycosyltransferases and their gene expression are altered in various pathophysiological situations including cancer. " 01/01/2015 - "We intend to use the new B2 library for carbohydrate differences found on cancers, where we profile the glycosyltransferases to predict classes of potential structures, and use the library for MS identification of the expected cohort of altered structures."
2.	Carcinoma (Carcinomatosis) 03/01/2000 - "RT-PCR determination of specific glycosyltransferases may be helpful for earlier detection of carcinomas and for tumour prognosis." 07/01/1981 - "Carcinoma-related alterations of glycosyltransferases in human tissues." 06/11/2003 - "For an understanding of tumor-related alterations of the complex carbohydrate pattern of carcinomas, it is indispensable to monitor the expression profile of the various glycosyltransferases. " 08/01/2013 - "A high expression of O-glycosylated proteins is one of the prominent characteristics of ovarian carcinoma cells associated with cell migration, which would be attributed to the upregulated expression of glycosyltransferases. " 05/01/2006 - "Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases."
3.	Neoplasm Metastasis (Metastasis) 08/01/1987 - "Such specific inhibitors of glycosyltransferases may serve as specific probes to study various glycosyltransferases that might be involved in the process of metastasis." 04/01/2014 - "Therefore, elucidation of glycosyltransferases and their substrates may improve our understanding of their roles in tumor metastasis. " 01/01/2014 - "HBx targets the specific glycosyltransferases for the SLA synthesis and this process regulates hematogenous cancer cell adhesion to endothelial cells for cancer metastasis." 08/01/2013 - "Therefore, elucidating glycosyltransferases and their substrates may improve our understanding of their roles in tumor metastasis. " 03/01/2012 - "The activity of upregulated glycosyltransferases was analyzed by their sugar residues end products using lectin histochemistry on primary tumors and metastases in the animal experiments and on 2,085 clinical samples. "
4.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2001 - "The aim of the present study was to examine tumor-associated alterations of glycosyltransferases involved in the biosynthesis of the TF glycotope in colorectal carcinomas. " 11/01/2013 - "Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). " 07/01/2008 - "We compared the expression levels of "glyco-genes," including glycosyltransferases and glycosidases, in normal GI mucosa and in gastric and colorectal cancer cells. " 04/01/2014 - "Aberrant glycosylation of cell surface glycoproteins is commonly associated with the invasion and metastasis of colorectal carcinomas, which can be attributed to the upregulated expression of glycosyltransferases. " 03/01/2000 - "Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 03/10/2006 - "The goal of this study was to identify glycosyltransferases that are specifically expressed in pancreatic cancer. " 09/30/2014 - "Here, we used exome sequencing of most glycosyltransferases in a large series of primary and metastatic pancreatic cancers to rule out somatic mutations as a cause of expression of truncated O-glycans. " 03/10/2006 - "To investigate the gene expression of glycosyltransferases between pancreatic cancer and normal pancreatic tissues, we performed DNA-microarray (involving about 1000 oligosaccharide-related genes) using RNA mixtures of pancreatic cancer cells and normal pancreatic tissues. " 09/01/2015 - "Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Glycopeptides
3.	Antigens
4.	Oligosaccharides
5.	Sulfotransferases
6.	Uridine Diphosphate (UDP)
7.	Cytochrome P-450 CYP3A
8.	Oxidoreductases
9.	Galactosyltransferases
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Therapeutics