1,2,5,8-tetrahydroxy anthraquinone

12/01/2019 - "Quinalizarin, a bioactive and highly selective compound, is known to promote apoptosis in colon and lung cancer cells. "
02/01/2018 - "MTT assays were used to evaluate the effects of quinalizarin on the viability of lung cancer A549, NCI‑H460 and NCI‑H23 cells. "
02/01/2018 - "However, the underlying regulatory mechanism and signalling pathways of quinalizarin in lung cancer cells remains unknown. "
02/01/2018 - "Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways."
12/01/2015 - "Meanwhile, we also found that the cell migration of different pathological types of lung cancer cells (H446, H460, A549) was significantly decreased by Quinalizarin dose-dependently. "

06/03/2018 - "BACKGROUND Quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) exhibits potentially useful anticancer effects by inducing apoptosis in several types of cancer, but its underlying mechanism of action remains unknown. "
02/01/2018 - "Quinalizarin may be a potential chemical agent for cancer therapy, as it exerts anti‑tumour effects against a variety of different types of cancer. "
11/01/2019 - "Thus, quinalizarin may be useful for human breast cancer treatment, as well as the treatment of other cancer types."
02/01/2021 - "Quinalizarin (Quina) is one of the main components of many herbal medicines and has good anti-tumor activity. "
01/01/2015 - "Here, by profiling quinalizarin on a larger panel of 140 kinases we reach the conclusion that quinalizarin is one of the most selective inhibitors of CK2, superior to the first-in-class CK2 inhibitor, CX-4945, now in clinical trials for the treatment of cancer. "

06/03/2018 - "Quinalizarin induced apoptosis in colorectal cancer cells by regulating MAPK and STAT3 signaling pathways via ROS generation. "
06/03/2018 - "The present study examined the effects of quinalizarin on the induction of cell cycle arrest, apoptosis, the generation of reactive oxygen species (ROS), other underlying mechanisms, and its role in modifying colorectal cancer cell lines. "
06/03/2018 - "Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells."

12/01/2019 - "In the present study, we investigated the underlying mechanisms of antimelanoma activity of quinalizarin in human melanoma A375 cells. "
12/01/2019 - "However, studies evaluating quinalizarin-induced apoptosis in melanoma cells have not been conducted. "
12/01/2019 - "In summary, quinalizarin induces cell cycle arrest and apoptosis via ROS-mediated MAPK and STAT3 signaling pathways in human melanoma A375 cells, and quinalizarin may be used as a novel and effective antimelanoma therapeutic."
12/01/2019 - "The results revealed a significant dose and time dependent effect of quinalizarin on inhibiting proliferation in three kinds of human melanoma cells, and had no significant toxic effects on normal cells. "
12/01/2019 - "Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells."

03/01/2016 - "The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. "
03/01/2016 - "Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression."