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STA-21

STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and reduces the survival of breast carcinoma cells with constitutive Stat3 signaling; structure in first source

Networked: 14 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- STA-21: 14

Experts

1.	Lin, Jiayuh: 3 articles (10/2008 - 03/2005)
2.	Cho, Mi-La: 2 articles (04/2020 - 04/2014)
3.	Al-Shabanah, Othman A: 2 articles (01/2017 - 01/2017)
4.	Attia, Sabry M: 2 articles (01/2017 - 01/2017)
5.	Nadeem, Ahmed: 2 articles (01/2017 - 01/2017)
6.	Zoheir, Khairy M A: 2 articles (01/2017 - 01/2017)
7.	Cen, Ling: 2 articles (10/2008 - 06/2007)
8.	Chan, Christina: 2 articles (10/2008 - 06/2007)
9.	Chen, Chun-Liang: 2 articles (10/2008 - 06/2007)
10.	Cheng, Gong: 2 articles (10/2008 - 06/2007)

Related Diseases

1.	Disease Progression 04/01/2014 - "STA-21 improved the clinical course of arthritis in IL-1Ra-KO mice. " 01/01/2017 - "STA-21 enhanced the clinical course of arthritis in CAIA mice and decreased CD8+RORγt+ and CD8+IL-21+ cells while inducing the production of CD8+Foxp3+ cells. "
2.	Arthritis (Polyarthritis) 04/01/2014 - "STA-21 suppressed inflammatory arthritis in IL-1Ra-KO mice. " 04/01/2014 - "STA-21 improved the clinical course of arthritis in IL-1Ra-KO mice. " 01/01/2017 - "STA-21 enhanced the clinical course of arthritis in CAIA mice and decreased CD8+RORγt+ and CD8+IL-21+ cells while inducing the production of CD8+Foxp3+ cells. " 01/01/2017 - "We set out to investigate the influence of STA-21, a dynamic STAT-3 inhibitor, on the expansion and progression of rheumatoid arthritis (RA), and to determine its potential mechanisms of action in a mouse model of collagen antibody-induced arthritis (CAIA). " 01/01/2017 - "STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis."
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/01/2023 - "STA-21, a small molecule STAT3 inhibitor, ameliorates experimental autoimmune encephalomyelitis by altering Th-17/Treg balance."
4.	Inflammation (Inflammations) 01/15/2017 - "Topical application of STA-21, a small molecule STAT3 inhibitor significantly reduced airway inflammation in allergic mice having psoriatic inflammation. " 06/01/2023 - "STA-21 ameliorated the EAE severity and decreased the EAE inflammation and demyelination. " 04/01/2014 - "STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis." 06/01/2023 - "This study showed that STA-21 has therapeutic effects in EAE by reducing inflammation and shifting inflammatory immune responses to anti-inflammatory and can be used as a suitable treatment strategy for the treatment of EAE. " 01/01/2017 - "STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis."
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/01/2020 - "This study aimed to assess the effect of the combination of ERK2 inhibitor VX-11e and STAT3 inhibitor STA-21 on acute lymphoblastic leukemia cell lines REH and MOLT-4. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Vx-11e
3.	Collagen Type II (Type II Collagen)
4.	Interleukin-17 (Interleukin 17)
5.	Caspases
6.	Interleukin-1 Receptors (Interleukin 1 Receptor)
7.	Cytokines
8.	Transcription Factors (Transcription Factor)
9.	Lipopolysaccharides
10.	Collagen