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curvularin

from Penicillium Baradicum Baghdadi; structure

Also Known As:

10,11-dehydrocurvularin

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        Zearalenone: 227
        curvularin: 9
- Lactones: 1549
  - Zearalenone: 227
    - curvularin: 9
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Zearalenone: 227
      - curvularin: 9

Experts

1.	Li, Xiang: 2 articles (05/2021 - 10/2009)
2.	Zou, Kun: 2 articles (04/2019 - 10/2009)
3.	Art, Julia: 2 articles (10/2012 - 03/2010)
4.	Erkel, Gerhard: 2 articles (10/2012 - 03/2010)
5.	Kleinert, Hartmut: 2 articles (10/2012 - 03/2010)
6.	Pautz, Andrea: 2 articles (10/2012 - 03/2010)
7.	Schmidt, Nadine: 2 articles (10/2012 - 03/2010)
8.	Bi, Yun: 1 article (05/2021)
9.	Deng, Zhang-Shuang: 1 article (05/2021)
10.	Guo, Jian: 1 article (05/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2009 - "With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alphabeta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the structure-activity relationship demonstrated that both compounds exhibited differences in bioactive profiles which are highly associated with their minor structural differences. " 04/04/2019 - "Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues."
2.	Glioma (Gliomas) 12/05/2022 - "In this study, we investigate the glioblastoma inhibitory activity of 10,11-dehydrocurvularin (DCV), a polyketide compound with broad biological activities, despite the fact that its anti-glioma properties and related mechanisms have yet to be studied. "
3.	Glioblastoma (Glioblastoma Multiforme) 12/05/2022 - "Inhibition of human glioblastoma multiforme cells by 10,11-dehydrocurvularin through the MMP-2 and PI3K/AKT signaling pathways." 12/05/2022 - "In this study, we investigate the glioblastoma inhibitory activity of 10,11-dehydrocurvularin (DCV), a polyketide compound with broad biological activities, despite the fact that its anti-glioma properties and related mechanisms have yet to be studied. "
4.	Inflammation (Inflammations) 04/01/2021 - "Curvularin (Cur), a fungal macrolactone, is known for its anti-inflammatory activity, but nothing is known about its impact on inflammation due to disk pathologies. " 03/01/2023 - "10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation."
5.	Necrosis 01/01/1989 - "Mycotoxin, Curvularin, produced hepatic necrosis."

Related Drugs and Biologics

1.	Polyketides
2.	dehydrocurvularin
3.	ethyl acetate
4.	Inflammasomes
5.	Macrolides
6.	Cytokines
7.	Mycotoxins
8.	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)