fucoidan

04/02/2024 - "We found that the anti-tumor effect of the combination treatment was significantly enhanced, while fucoidan significantly improved the composition of the gut microbiota by increasing the number of potentially beneficial bacteria, such as Bifidobacterium, Faecalibaculum and Lactobacillus. "
11/23/2021 - "Fucoidan-Based Nanoparticles with Inherently Therapeutic Efficacy for Cancer Treatment."
07/01/2020 - "Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. "
01/01/2014 - "Despite a number of in vitro and in vivo studies reporting the efficacy of fucoidan in treating various cancers, few studies have measured the efficacy of dietary fucoidan (DF) in combination with cancer drugs. "
01/15/2024 - "Rationally designed clinical trials for the critical evaluation of fucoidan against different cancers will be valuable to reap full benefits."

04/01/2023 - "Concerning phagocytosis, however, the inflammation-induced reduction was not improved by FV fucoidan. "
12/11/2021 - "These observations on various fucoidan extracts offer insight into strategies that improve their efficacy against inflammation-related pathology. "
01/31/2021 - "Low molecular weight fucoidan fraction ameliorates inflammation and deterioration of skin barrier in fine-dust stimulated keratinocytes."
08/29/2023 - "This study suggested that fucoidan had anti-inflammatory potentials and thus can be used as a promising drug candidate against inflammation.Communicated"
12/23/2022 - "The present study emphasized the effect of low-molecular-weight fucoidan isolated from Sargassum confusum (LMF) against FD-induced inflammation in HaCaT keratinocytes and underneath fibroblasts (HDFs) in an integrated culture model. "

12/01/2008 - "A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. "
04/01/2024 - "The rats were treated with fucoidan at a dose of 50 mg/kg. body weight showed improved spatial learning and memory compared to the lesion group and the cytoarchitecture of CA1 pyramidal cells was observed to be well preserved. "
02/01/2024 - "In contrast to the DSS-induced UC model, fucoidan intervention prevented DSS-induced body weight loss, mitigated colon shortening, improved colon mucosa damage, enhanced the intestinal barrier, and reduced serum inflammatory factor concentrations. "
03/01/2011 - "After 3 weeks, fucoidan treatment improved left ventricular ejection fraction (79.04 ± 2.81 vs 65.94% ± 3.22%; P < .01 vs EAM-saline) with a reduced ratio of heart weight to body weight (4.016 ± 0.239 vs 4.975 ± 0.252 mg/g; P < .05 vs EAM-saline) in EAM. "
02/01/2024 - "For our study, we chose 36 male C57BL/6 mice and administered 100 or 400 mg/(kg/body weight/day) of fucoidan via gavage for 5 consecutive weeks. "

02/21/2018 - "The study suggested the use of fucoidan as an intestinal flora modulator for potential prevention of breast cancer."
10/01/2013 - "In this study, the effect of Fucoidan on the proliferation and apoptosis of human breast cancer MCF-7 cells and the molecular mechanism of Fucoidan action were investigated. "
04/01/2013 - "This study is the first to identify a novel mechanism for fucoidan antitumor activity, namely regulation of the EMT via modulation of TGFR/Smad-dependent signaling, which leads to an inhibition of breast cancer cell growth in vitro and in vivo. "
01/01/2012 - "In this study, we examined the influence of crude fucoidan on mouse breast cancer in vitro and in vivo. "
04/03/2024 - "Moreover, the fucoidan extract exhibited toxicity to breast cancer cells (MCF-7) at 297.58 ± 2.40 ppm. "

05/01/2024 - "Fucoidan significantly improved the GFR hyperfiltration and renal fibrosis. "
08/02/2023 - "The present study investigated the protective function of fucoidan in renal fibrosis and its pharmacological mechanism. "
05/25/2023 - "In this study, a fucoidan from Costaria costata was isolated, and its anti-idiopathic fibrosis activity was investigated both in vitro and in vivo. "
07/05/2022 - "This study investigated the anti-fibrotic effect of fucoidan on oral fibrosis. "
10/08/2020 - "In this study, we investigated the effects of low-molecular-weight fucoidan (oligo-FO) on renal fibrosis under in vitro and in vivo diabetic conditions, and its molecular mechanisms. "