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Fusion protein Tc24-C4

consists of Trypanosoma cruzi antigen Tc24-C4 fused to ten nonameric CD8 + epitopes

Also Known As:

Tc24-C4

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Recombinant Fusion Proteins: 333
      - Fusion protein Tc24-C4: 3
  - Protozoan Proteins
    - Fusion protein Tc24-C4: 3

Experts

1.	Adhikari, Rakesh: 1 article (01/2021)
2.	Bottazzi, Maria Elena: 1 article (01/2021)
3.	Hotez, Peter J: 1 article (01/2021)
4.	Jones, Kathryn M: 1 article (01/2021)
5.	Pollet, Jeroen: 1 article (01/2021)
6.	Poveda, Cristina: 1 article (01/2021)
7.	Tijhaar, Edwin: 1 article (01/2021)
8.	Versteeg, Leroy: 1 article (01/2021)
9.	Villar-Mondragon, Maria Jose: 1 article (01/2021)

Related Diseases

1.	Parasitemia 10/26/2022 - "Tc24-C4.10E-treated mice showed a decreased parasitemia compared to the Tc24-C4 (non-adjuvant) immunized mice or control group. " 01/01/2021 - "When combined with Toll-like receptor agonists, Tc24-C4 immunization reduces parasitemia, parasites in cardiac tissue, and cardiac fibrosis and inflammation in animal models. "
2.	Inflammation (Inflammations) 01/01/2021 - "When combined with Toll-like receptor agonists, Tc24-C4 immunization reduces parasitemia, parasites in cardiac tissue, and cardiac fibrosis and inflammation in animal models. " 01/01/2022 - "The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, and TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite burdens, heart inflammation, and fibrosis, leading us to envision their use as immunotherapy together with BNZ. "
3.	Fibrosis (Cirrhosis) 01/01/2021 - "When combined with Toll-like receptor agonists, Tc24-C4 immunization reduces parasitemia, parasites in cardiac tissue, and cardiac fibrosis and inflammation in animal models. " 01/01/2022 - "The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, and TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite burdens, heart inflammation, and fibrosis, leading us to envision their use as immunotherapy together with BNZ. "
4.	Chagas Disease (American Trypanosomiasis) 10/26/2022 - "These results suggest that the addition of the MHC Class I epitopes to Tc24-C4 can synergize the antigen-specific cellular immune responses, providing proof-of-concept that this approach could lead to the development of a promising vaccine candidate for Chagas disease."
5.	Cardiomyopathies (Cardiomyopathy) 01/01/2021 - "Tc24-C4, a modified recombinant flagellar calcium-binding protein of Trypanosoma cruzi, is under development as a therapeutic subunit vaccine candidate to prevent or delay progression of chronic Chagasic cardiomyopathy. "

Related Drugs and Biologics

1.	Antigens
2.	Toll-Like Receptor 4
3.	Subunit Vaccines
4.	Vaccines
5.	Calcium-Binding Proteins
6.	Epitopes
7.	Toll-Like Receptor Agonists
8.	thymic shared antigen-1

Related Therapies and Procedures

1.	Immunotherapy