thymic shared antigen-1

TSA-1 is identical to Sca-2; a mouse thymocyte marker; a phosphatidylinositol-linked surface protein, member of the Ly6 family; amino acid sequence given in first & second source; GenBank U04268

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dumonteil, Eric: 4 articles (01/2019 - 08/2007)
2.	Bottazzi, Maria Elena: 2 articles (01/2019 - 01/2018)
3.	Ortega-Lopez, Jaime: 2 articles (01/2019 - 01/2018)
4.	Chang, Lung-Ji: 2 articles (04/2006 - 06/2004)
5.	He, Jin: 2 articles (04/2006 - 06/2004)
6.	Dzul-Huchim, Victor: 1 article (01/2019)
7.	Flores-Pucheta, Claudia Ivonne: 1 article (01/2019)
8.	Gillespie, Portia: 1 article (01/2019)
9.	Hotez, Peter J: 1 article (01/2019)
10.	Martinez-Vega, Pedro: 1 article (01/2019)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 01/01/2019 - "Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice." 04/26/2013 - "These results indicate that a preventive or therapeutic DNA vaccine encoding TSA-1 and Tc24 antigens is safe and may reduce both parasite transmission and the clinical progression of Chagas disease in vaccinated dogs. " 08/01/2007 - "These data demonstrate that therapeutic vaccine efficacy is dependent on the antigen and suggest that DNA vaccines encoding Tc24, TSA-1, and Tc52 represent the best candidates for further studies of a therapeutic vaccine against Chagas disease."
2.	Parasitemia 08/01/2007 - "Finally, treatment with plasmids encoding Tc24 and TSA-1 induced the most complete control of disease as evidenced by significant reductions in parasitemia, mortality, myocarditis and heart parasite burden. " 01/01/2019 - "TSA-1 with the TLR-4 agonists was effective at reducing parasitemia relative to rTSA-1 alone, although it was difficult to discern a therapeutic effect compared to treatment with TLR-4 agonists alone. "
3.	Proteinuria 01/01/2004 - "Increased expression of TSA-1, a member of the Ly-6 family, has previously been reported in response to proteinuria. " 05/01/2002 - "The increased expression of TSA-1, a member of the Ly-6 family, and of GS188 in response to proteinuria was confirmed by Northern analysis, immunohistochemistry, in situ hybridization and laser microdissection along with real-time PCR analysis. "
4.	Infections 10/01/1994 - "cruzi infection and after immunization with TSA-1, subregions of the TSA-1 gene were expressed in a bacterial expression system. " 01/01/2018 - "In conclusion, our results confirm the ability of both TSA-1 and Tc24 recombinant proteins to recall an immune response induced by the native antigens during natural infection in at least some patients. "
5.	Hepatocellular Carcinoma (Hepatoma) 06/01/2004 - "Functional characterization of hepatoma-specific stem cell antigen-2." 04/24/2006 - "Using three highly differentially expressed hepatoma tumor-associated antigens (TAAs): stem cell antigen-2 (Sca-2), glycoprotein 38 (GP38) and cellular retinoic acid binding protein 1 (RABP1), we explored the therapeutic potential of the DCs modified with lentiviral vectors (LVs). "

Related Drugs and Biologics

1.	Antigens
2.	DNA Vaccines
3.	Vaccines
4.	Toll-Like Receptor 4
5.	Therapeutic Uses
6.	A-Form DNA (A-DNA)
7.	CD40 Ligand (CD40L)
8.	Contraceptive Vaccines
9.	Tretinoin (Retinoic Acid)
10.	Recombinant Proteins

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Immunotherapy