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01/01/2020 - "Auxora demonstrated a favorable safety profile in patients with severe or critical COVID-19 pneumonia and improved outcomes in patients with severe COVID-19 pneumonia. "
01/01/2022 - "Further studies of Auxora in patients with severe COVID-19 pneumonia are warranted. "
01/01/2020 - "The impact of Auxora on respiratory complications in patients with severe COVID-19 pneumonia will be further assessed in a planned randomized, blinded, placebo-controlled study. "
01/01/2020 - "A randomized, controlled, open-label study of Auxora was conducted in adults with severe or critical COVID-19 pneumonia. "
01/01/2022 - "Auxora was safe and well tolerated with strong signals in both time to recovery and all-cause mortality through Day 60 in patients with severe COVID-19 pneumonia. "

01/01/2020 - "Auxora demonstrated a favorable safety profile in patients with severe or critical COVID-19 pneumonia and improved outcomes in patients with severe COVID-19 pneumonia. "
01/01/2022 - "Further studies of Auxora in patients with severe COVID-19 pneumonia are warranted. "
01/01/2020 - "The impact of Auxora on respiratory complications in patients with severe COVID-19 pneumonia will be further assessed in a planned randomized, blinded, placebo-controlled study. "
01/01/2020 - "A randomized, controlled, open-label study of Auxora was conducted in adults with severe or critical COVID-19 pneumonia. "
01/01/2022 - "Auxora was safe and well tolerated with strong signals in both time to recovery and all-cause mortality through Day 60 in patients with severe COVID-19 pneumonia. "

01/01/2019 - "This study investigates the effects of CM4620 in preventing or reducing acute pancreatitis features and severity. "
01/01/2019 - "Using CM4620, we show that SOCE via STIM1/Orai complexes promotes neutrophil oxidative burst and inflammatory gene expression during acute pancreatitis, including in immune cells which may be either circulating or invading the pancreas. "
01/01/2019 - "Here we report that intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. "
01/01/2019 - "The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis."
01/01/2019 - "CM4620 administration to rats by i.v. infusion starting 30 min after induction of pancreatitis significantly diminished pancreatitis features including pancreatic oedema, acinar cell vacuolization, intrapancreatic trypsin activity, cell death signalling and acinar cell death. "

01/01/2021 - "This phase 2, open-label, dose-response study randomized patients with AP, accompanying SIRS, and hypoxemia (n = 21) to receive low-dose or high-dose Auxora plus standard of care (SOC) or SOC alone. "
01/01/2017 - "The following new synonymies are proposed [valid names in brackets]: Auxora [Nebria Latreille, 1806; Carabidae], Necrotroctes [Velleius Leach, 1819; Staphylinidae], Epimachus [Ochthephilum Stephens, 1829; Staphylinidae], Ocys [Anaulacaspis Ganglbauer, 1895; Staphylinidae], Hydatobia [Autalia Samouelle, 1819; Staphylinidae], Hedonius [Pyrophorus Billberg, 1820; Elateridae], Charmionus [Chalcolepidius Eschscholtz, 1829; Elateridae], Lamprias [Alaus Eschscholtz, 1829; Elateridae], Trypheus [Aeolus Eschscholtz, 1829; Elateridae], Antiphus [Cardiorhinus Eschscholtz, 1829; Elateridae], Phyletus [Lygistopterus Dejean, 1833; Lycidae], Phyllogaster [Lucidota Laporte, 1833; Lampyridae], Pyrrhigius [Phosphaenus Laporte, 1833; Lampyridae], Erota [Luciola Laporte, 1833; Lampyridae], Oxypterus [Aspisoma Laporte, 1833; Lampyridae], Phyllophagus [Chauliognathus Hentz, 1830; Cantharidae], Epaphius [Astylus Laporte, 1836; Melyridae], Isomerus [Choleva Latreille, 1797; Leiodidae], Berecyntha [Aulacochilus Chevrolat, 1836; Erotylidae], Geophilus [Psammodius Fallén, 1807; Scarabaeidae], Ceraunus [Golofa Hope, 1837; Scarabaeidae], Atrimedeus [Pentodon Hope, 1837; Scarabaeidae], Eupalus [Temnorhynchus Hope, 1837; Scarabaeidae], Polycarmes [Anoxia Laporte, 1832; Scarabaeidae], Acidota [Amphicoma Latreille, 1807; Glaphyridae], Cecrops [Mylaris Pallas, 1781; Tenebrionidae], Pythonissus [Zophobas Dejean, 1834; Tenebrionidae], Physignathus [Cymatothes Dejean, 1834; Tenebrionidae], Pelops [Prionychus Solier, 1835; Tenebrionidae], Accantosomus [Semiotus Eschscholtz, 1829; Elateridae]. "
01/01/2021 - "To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy endpoints to prospectively test in future studies. "

01/01/2021 - "To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy endpoints to prospectively test in future studies. "
01/01/2021 - "Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor."