Ivermectin (Mectizan)

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

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Networked: 1879 relevant articles (369 outcomes, 321 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Boussinesq, Michel: 23 articles (05/2015 - 07/2002)
2.	Kamgno, Joseph: 22 articles (05/2015 - 07/2002)
3.	Boussinesq, M: 20 articles (07/2011 - 01/2000)
4.	Wanji, Samuel: 19 articles (01/2015 - 02/2007)
5.	Hoerauf, Achim: 17 articles (08/2015 - 04/2003)
6.	Prichard, Roger K: 17 articles (06/2015 - 08/2005)
7.	Basáñez, María-Gloria: 15 articles (07/2015 - 01/2003)
8.	Richards, Frank O: 15 articles (09/2014 - 09/2002)
9.	Amazigo, Uche V: 13 articles (09/2015 - 02/2007)
10.	Pion, Sébastien D S: 13 articles (05/2015 - 07/2003)

Related Diseases

1.	Infection 12/01/2005 - "Ivermectin treatment was highly effective in eliminating the ticks, but showed no apparent effect on the dogs nor on their trypanosome infection. " 01/01/1997 - "Taking into account uncertainty about the efficacy of ivermectin, our results indicate that, provided treatment coverage is at least 65% and there is no importation of infection from elsewhere, 12 years of combined control will be sufficient to reduce the risk of recrudescence to below 1% in even the most afflicted areas." 01/01/1990 - "Ivermectin treatment appears to be the most appropriate method for control of recrudescence of infection in an area where the parasite reservoir has been virtually eliminated by vector control, such as in the core area of the OCP." 12/01/1986 - "americanus were completely cured of infection by doses of 15 mg kg-1 or 7.5 mg kg-1 X 2. The doses of ivermectin required for complete elimination of N. " 04/01/1998 - "Several studies, both fly-feeding experiments and community trials, have established that Mectizan treatment causes a significant reduction in the transmission of infection. "
2.	Scabies (Sarcoptic Mange) 07/01/1999 - "We describe a case of crusted scabies, induced by long-term application of a topical corticosteroid, relapsing after topical treatment and dramatically improved by ivermectin. " 01/01/2001 - "To study the efficacy of ivermectin for scabies, which is very common in Colombia, a trial with this drug that could be easily administered, with fast application and high efficacy, was undertaken. " 11/01/1998 - "The advantages of oral ivermectin treatment in scabies patients are: high therapeutic efficacy against Sarcoptes scabiei, good tolerance and influence of the drug on the whole skin surface and on clinical symptoms. " 03/01/1998 - "All patients were successfully cured of scabies with a twice oral dose of 200 microg/kg ivermectin within 8 days. " 01/01/1998 - "The authors conclude that ivermectin is effective for crusted scabies; however, multiple doses may be required to achieve a cure, and recurrence 6 or more weeks after completing treatment is common."
3.	Onchocerciasis 04/01/2004 - "Through the extensive clinical testing protocols implemented in a variety of countries in Aftica, ivermectin has been proven to be a safe and highly effective treatment for onchocerciasis. " 05/01/1994 - "Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. " 10/01/2004 - "This shows that Community Directed Treatment with Ivermectin (CDTI) campaign is successful and should be sustained until onchocerciasis is eliminated as a public health problem in the area." 04/01/2004 - "If ivermectin-based programmes for the control of human onchocerciasis are to be successful, the drug must remain effective for as long as necessary. " 09/01/2002 - "Successful control of onchocerciasis through mass distribution of ivermectin needs to be coupled with reliable, sensitive, specific, yet affordable diagnostic methods to monitor and ensure the efficacy of such measures. "
4.	Body Weight (Weight, Body) 06/01/1988 - "The results of five trials conducted in Paraguay, Brazil and Colombia showed that ivermectin administered subcutaneously at a dose level of 200 mcg/kg body weight was highly effective against the three larval stages of D. " 04/01/1998 - "All dogs improved when ivermectin was administered (200-400 micrograms/kg body weight); however, most (3/4) required serial treatments in order to achieve long-term resolution of clinical signs." 01/01/1987 - "Ivermectin, added to the drinking water for the elimination of murine oxyurids, over a 24-hour period, in a dosage of 1.0 (males) and 1.6 mg/kg body weight (females), proved to be highly effective against A. " 10/01/2013 - "All the infested sheep were treated successfully with Ivermectin at 200 μg/kg body weight and complete recovery of skin was observed between 10th and 14th day post treatments. " 01/01/1987 - "The antiparasitic agent Ivermectin (0.3 mg/100 g body-weight) was effective against Crenosoma striatum (efficacy: 95.9%) and Capillaria spp. (100%); therefore it can be recommended as a new, well tolerated anthelmintic against nematodes of the hedgehog."
5.	Strongyloidiasis 12/01/2004 - "In chronic uncomplicated strongyloidiasis, a treatment regimen consisting of ivermectin 200 mug/kg for 2 consecutive days provided the best results with regard to efficacy and tolerability. " 12/01/2004 - "Ivermectin has been shown to be more effective for treating chronic uncomplicated strongyloidiasis. " 01/01/2016 - "Despite the limited published experience of parenteral ivermectin use, there is evidence that it may be a safe and effective treatment for severe strongyloidiasis. " 05/01/2007 - "Parenteral ivermectin is found to be useful in the treatment of disseminated strongyloidiasis. " 07/01/1992 - "[Clinical study of eradicated and resistant patients to treatment with ivermectin for strongyloidiasis]."

Related Drugs and Biologics

1.	Diethylcarbamazine (Hetrazan)
2.	Albendazole (Albenza)
3.	doramectin
4.	Ivermectin (Mectizan)
5.	Permethrin (Ambush)
6.	milbemycin (moxidectin)
7.	Levamisole (Decaris)
8.	Fenbendazole
9.	Praziquantel (Biltricide)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Subcutaneous Injections
5.	Combination Drug Therapy (Combination Chemotherapy)