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Panax notoginsenoside saponin Rb1

modulates Akt-mTOR-PTEN signaling; has neuroprotective effects in rats following ischemic stroke

Also Known As:

saponin Rb1, Panax notoginsenoside; PNS-Rb1

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Panax notoginsenoside saponin Rb1: 2

Experts

1.	Luo, Hai-Yun: 2 articles (10/2019 - 01/2018)
2.	Xiong, Yun-Xia: 2 articles (10/2019 - 01/2018)
3.	Zhou, Xin-Fu: 2 articles (10/2019 - 01/2018)
4.	Hu, Sheng: 1 article (10/2019)
5.	Ma, Jia-Qing: 1 article (10/2019)
6.	Su, Hui: 1 article (10/2019)
7.	Sun, Jun: 1 article (10/2019)
8.	Yang, Chun-Yan: 1 article (10/2019)
9.	Yang, Jian-Yu: 1 article (10/2019)
10.	Zhuang, Xue-Feng: 1 article (10/2019)

Related Diseases

1.	Ischemic Stroke 01/01/2018 - "Our results indicate that PNS-Rb1 significantly alleviated the morphological lesion concomitant with improvement of cognitive and sensorimotor deficits induced by ischemic stroke. " 10/01/2019 - "Taken together, our findings indicate that the improvement of sensorimotor dysfunctions by PNS-Rb1 following ischemic stroke is made, at least partially, by activating the BDNF/TrkB and inhibiting proBDNF/sortilin/P75NTR." 10/01/2019 - "Our data indicate that PNS-Rb1 significantly reduced cerebral infarction rate, proBDNF/P75NTR/sortilin, and plasminogen activator inhibitor-1 (PAI-1) protein levels, and improved sensorimotor dysfunctions induced by ischemic stroke, upregulation of BDNF/TrkB levels, and its processing enzymes (tissue plasminogen activator, tPA) in a time-dependent manner. "
2.	Cerebral Infarction 10/01/2019 - "Our data indicate that PNS-Rb1 significantly reduced cerebral infarction rate, proBDNF/P75NTR/sortilin, and plasminogen activator inhibitor-1 (PAI-1) protein levels, and improved sensorimotor dysfunctions induced by ischemic stroke, upregulation of BDNF/TrkB levels, and its processing enzymes (tissue plasminogen activator, tPA) in a time-dependent manner. "
3.	Stroke (Strokes) 10/01/2019 - "To test this hypothesis, rats induced by photothrombotic stroke were treated with PNS-Rb1 100 mg/kg or nimodipine 1 mg/kg twice a day until 3, 7, and 14 days. " 01/01/2018 - "To test this hypothesis, rats with induced photothrombotic stroke were treated with PNS-Rb1 (applied in three different doses, 25 mg/kg, 50 mg/kg,100 mg/kg, respectively) or saline, while sham operated rats injected with saline were used as the control. " 01/01/2018 - "We asked whether the potential neuroprotection of PNS-Rb1 on the brain is due to, at least partially, its modulation of AkT/mTOR/PTEN signalling pathway along with down-regulation of caspase-3 in rats subjected to phototrombic stroke. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Proteins (Proteins, Gene)
3.	Plasminogen Activators (Plasminogen Activator)
4.	Tissue Plasminogen Activator (Alteplase)
5.	Enzymes
6.	sortilin
7.	Caspase 3 (Caspase-3)
8.	Nimodipine (Modus)
9.	salicylhydroxamic acid (SHAM)