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PB-2452

used as an antidote for ticagrelor poisoning

Also Known As:

MEDI-2452; MEDI2452; PB2452

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 664
      - Purine Nucleosides: 362
        Adenosine: 12597
        Ticagrelor: 2461
        PB-2452: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6937
  - Purine Nucleosides: 362
    - Adenosine: 12597
      - Ticagrelor: 2461
        PB-2452: 1
  - Ribonucleosides: 49
    - Adenosine: 12597
      - Ticagrelor: 2461
        PB-2452: 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Serum Globulins: 555
      - Immunoglobulins: 30911
        Antibodies: 135587
        Neutralizing Antibodies: 10244
        Broadly Neutralizing Antibodies: 813
        PB-2452: 1
    - Immunoproteins: 43
      - Immunoglobulins: 30911
        Antibodies: 135587
        Neutralizing Antibodies: 10244
        Broadly Neutralizing Antibodies: 813
        PB-2452: 1
  - Globulins: 3119
    - Serum Globulins: 555
      - Immunoglobulins: 30911
        Antibodies: 135587
        Neutralizing Antibodies: 10244
        Broadly Neutralizing Antibodies: 813
        PB-2452: 1

Experts

1.	Almquist, J: 1 article (01/2017)
2.	Gennemark, P: 1 article (01/2017)
3.	Goodman, J: 1 article (01/2017)
4.	Janefeldt, A: 1 article (01/2017)
5.	Johansson, K J: 1 article (01/2017)
6.	Maqbool, S: 1 article (01/2017)
7.	Nylander, S: 1 article (01/2017)
8.	Pehrsson, S: 1 article (01/2017)
9.	Sanchez, J: 1 article (01/2017)
10.	Sandinge, A-S: 1 article (01/2017)

Related Diseases

1.

Body Weight (Weight, Body)

01/01/2017 - "MEDI2452 numerically reduced ticagrelor-mediated effects: body-weight-adjusted blood loss in the 15- to 90-min interval, 12 (confidence interval [CI] 95% 7-28] vs. 17 (CI 95% 5-31) (ticagrelor and aspirin) vs. 5 (CI 95% 3-9) mL kg-1 (aspirin alone), survival 70% (CI 95% 47-100) vs. 45% (CI 95% 21-92) (ticagrelor and aspirin) vs. 100% (CI 95% 100-100) (aspirin alone), and median survival time, 240 (CI 95% 180-240) vs. 169 (CI 95% 64-240) (ticagrelor and aspirin) vs. 240 (CI 95% 240-240) min (aspirin alone). "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Ticagrelor