Ribonucleosides

01/01/2012 - "Development of antiviral ribonucleosides for treatment of hepatitis C virus (HCV) infection has been hampered by appearance of toxicity during clinical trials that evaded detection during preclinical studies. "
07/01/2003 - "These results demonstrate that the benzimidazole ribonucleosides are active against human CMV and EBV and suggest that they may be useful for the treatment of infections caused by these herpesviruses."
07/01/1998 - "The results suggest that guanine ribonucleosides may be useful to treat infections with intracellular pathogens."
06/15/1998 - "Leishmania amazonensis infection is reduced in macrophages treated with guanine ribonucleosides."
07/01/2003 - "The protective in vivo effect during murine leishmaniasis as well as the lack of apparent toxicity of 8Brguo as attested by blood/serum pathology and histology from treated mice encourage further studies of C8-substituted guanine ribonucleosides, such as 8Brguo, as new leishmanial drugs and as modifiers of the immunological response to combat infections with intracellular pathogens."

07/21/2015 - "Taken together, this study established a promising strategy for the effective profiling of urinary modified ribonucleosides, and simultaneous evaluation of the contents change of multiple modified ribonucleosides should provide more accurate and conclusive results for the use of urinary modified ribonucleosides as indicators of cancers. "
07/21/2015 - "Detection of endogenous modified ribonucleosides in biological fluids may serve as a noninvasive cancers diagnostic method. "
07/21/2015 - "Some modified ribonucleosides in biological fluids have been evaluated as cancer-related metabolites. "
01/01/2007 - "Modified ribonucleosides serve as valuable pathobiochemical marker molecules for cancer. "
08/21/1998 - "Regarding the known function of ribonucleosides as pathobiochemical marker molecules for cancer, the possibility of a selective apoptotic effect against malignant cells is discussed."

07/01/2003 - "The protective in vivo effect during murine leishmaniasis as well as the lack of apparent toxicity of 8Brguo as attested by blood/serum pathology and histology from treated mice encourage further studies of C8-substituted guanine ribonucleosides, such as 8Brguo, as new leishmanial drugs and as modifiers of the immunological response to combat infections with intracellular pathogens."
10/01/2006 - "It has been shown previously that Sb(V) forms mono- and bis-adducts with adenine and guanine ribonucleosides, suggesting that ribonucleosides may be a target for pentavalent antimonial drugs in the treatment of leishmaniasis. "

06/01/2008 - "In the presented study, urinary ribonucleosides were used to differentiate between breast cancer patients and healthy volunteers. "

06/01/1965 - "SYNTHESIS OF 5-PHOSPHORIBOSYL 1-PYROPHOSPHATE FROM RIBONUCLEOSIDES IN EHRLICH ASCITES TUMOR CELLS IN VITRO."
10/01/1965 - "Inhibition of ribonucleoside metabolism in Ehrlich ascites tumor cells by purine analogue ribonucleosides."
10/11/1997 - "The conversion to corresponding triphosphate derivatives of various ribonucleosides has been studied in Ehrlich ascites tumor cells and in Chinese hamster ovary cells under conditions that are optimal for cellular uptake of orthophosphate. "