Typical Teratoid Rhabdoid Tumor

Also Known As:

Teratoid Rhabdoid Tumor; Teratoma Rhabdoid Tumor; Typical Teratoma Rhabdoid Tumor; Typical Teratoma-Rhabdoid Tumor

Networked: 146 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Germ Cell and Embryonal Neoplasms: 4454
    - Teratoma: 3316
      - Typical Teratoid Rhabdoid Tumor: 146
  - Complex and Mixed Neoplasms
    - Rhabdoid Tumor: 421
      - Typical Teratoid Rhabdoid Tumor: 146

Related Diseases

1.	Rhabdoid Tumor (Rhabdoid Tumors)
2.	Neoplasms (Cancer)
3.	Medulloblastoma
4.	Glioblastoma (Glioblastoma Multiforme)
5.	Ependymoma

Experts

1.	Hasselblatt, Martin: 7 articles (01/2022 - 06/2011)
2.	Frühwald, Michael C: 6 articles (01/2022 - 06/2011)
3.	Wong, Tai-Tong: 6 articles (01/2019 - 02/2005)
4.	Gajjar, Amar: 5 articles (06/2022 - 11/2006)
5.	Kool, Marcel: 5 articles (01/2022 - 12/2012)
6.	Siebert, Reiner: 5 articles (01/2022 - 06/2011)
7.	Huang, Annie: 5 articles (11/2020 - 12/2012)
8.	Jayanthan, Aarthi: 4 articles (01/2021 - 11/2008)
9.	Narendran, Aru: 4 articles (01/2021 - 11/2008)
10.	Oyen, Florian: 4 articles (01/2021 - 06/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Typical Teratoid Rhabdoid Tumor:

1.	MicroRNAs (MicroRNA)IBA 01/01/2017 - "Correction: Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA." 03/01/2014 - "Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA." 12/01/2012 - "Amplification of the miRNA cluster at 19q13.42 has been identified previously as a genetic hallmark for ETMR, but an immunohistochemistry-based assay for clinical routine diagnostics [such as INI-1 for atypical teratoid rhabdoid tumor (AT/RT)] is still lacking. " 10/01/2016 - "In this study, we analyzed the histological, immunohistochemical, microRNA, and clinicopathological statuses of tumors initially diagnosed as malignant rhabdoid tumor (n=33), atypical teratoid/rhabdoid tumor (n=11), and pediatric undifferentiated/unclassified sarcoma (n=8) with complete loss of SMARCB1/INI1 expression, and considered the possibility of their histological reclassification. " 02/01/2011 - "The present study provides an initial survey of miRNA expression in pediatric central nervous system (CNS) malignancies including atypical teratoid/rhabdoid tumor, ependymoma, glioblastoma, medulloblastoma, and pilocytic astrocytoma. "
2.	MLN 8237IBA 01/01/2023 - "Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor." 01/01/2022 - "Sustained and durable response with Alisertib monotherapy in the treatment of relapsed Atypical Teratoid Rhabdoid Tumor (ATRT)."
3.	Cyclin-Dependent Kinase 4IBA 11/01/2016 - "In this study, we examined the cyclin-dependent kinase 4/6 inhibitor palbociclib, when used in combination with radiation for treating human atypical teratoid rhabdoid tumor (ATRT) as well as glioblastoma (GBM). "
4.	Oxaliplatin (Eloxatin)FDA LinkGeneric 11/01/2006 - "An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). "
5.	palbociclibIBA 11/01/2016 - "Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth." 11/01/2016 - "In this study, we examined the cyclin-dependent kinase 4/6 inhibitor palbociclib, when used in combination with radiation for treating human atypical teratoid rhabdoid tumor (ATRT) as well as glioblastoma (GBM). "
6.	dipinacoline glutamateIBA 01/01/2023 - "Results from preclinical or observative studies and early-phase trials targeting B7-H3 have revealed promising anti-tumor efficacy and acceptable toxicity in glioblastoma (GBM), diffuse intrinsic pontine glioma (DIPG), medulloblastoma, neuroblastoma, craniopharyngioma, atypical teratoid/rhabdoid tumor, and brain metastases. "
7.	Proteins (Proteins, Gene)FDA Link 01/01/2018 - "Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is characterized by SMARCB1/INI deletion or mutation in the long arm of chromosome 22 11(22q11.2), also resulting in loss of nuclear expression of INI1 protein immunohistochemically. " 01/01/2022 - "Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. " 01/01/2022 - "Atypical teratoid/rhabdoid tumor (ATRT) is an aggressive central nervous system tumor characterized by loss of SMARCB1/INI1 protein expression and comprises three distinct molecular groups, ATRT-TYR, ATRT-MYC and ATRT-SHH. " 04/01/2021 - "Atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignant pediatric brain tumor, characterized by inactivation of INI1/hSNF5 gene and loss of its protein. " 10/01/2009 - "Rare intraparenchymal choroid plexus carcinoma resembling atypical teratoid/rhabdoid tumor diagnosed by immunostaining for INI1 protein."
8.	cytidylyl-(3'-5')-cytidine (CpC)IBA 05/01/2005 - "Central nervous system atypical teratoid/rhabdoid tumor (AT/RT) and choroid plexus carcinoma (CPC) are rare, highly malignant tumors that predominantly arise in infants and young children. " 10/01/2009 - "The initial pathological diagnosis was atypical teratoid/rhabdoid tumor (AT/RT); however, immunostaining for INI1 protein (using the BAF47/SNF5 antibody) showed retention of nuclear staining in the tumor cells, resulting in a change in the diagnosis to CPC. " 07/01/2009 - "Using a 7 T scanner, spectra were acquired from mice with a human atypical teratoid/rhabdoid tumor (AT/RT) either implanted directly from the surgical specimen or first grown in culture, directly implanted choroid plexus carcinoma (CPC), and two medulloblastoma cell lines. " 01/01/2022 - "Postoperative histopathological types include ependymoma, pilocytic astrocytoma, choroid plexus papilloma (CPP), craniopharyngioma, primitive neuroectoderm tumor (PNET), choroid plexus carcinoma (CPC), immature teratoma, atypical teratoid rhabdoid tumor (AT/RT), anaplastic astrocytoma, and gangliocytoma. "
9.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/01/2021 - "Although, PKHD1 mutations are also detected in certain cancer types, to our knowledge in rare tumors such as, atypical teratoid rhabdoid tumor (ATRT), primary neuro-ectodermal tumor (PNET), atypicalchoroid plexus papilloma (a-CPP), amelanotic ano-rectal melanoma (AMM), and breast phyllodes tumors PKHD1 mutations profiling is not reported. " 01/01/2019 - "Tumor types in order of frequency were choroid plexus papillomas (CPP, 17), primitive neuroectodermal tumor (12), atypical teratoid/rhabdoid tumor (10), high-grade glioma (9), optic glioma (9), ependymoma (8), low-grade glioma (6), pilocytic astrocytoma (6), choroid plexus carcinoma (5), and teratoma (5), with 11 miscellaneous tumors. " 01/01/2001 - "Immunohistochemistry for IGF-II and IGFR1 was performed on 15 choroid plexus papillomas (CPPs) including 1 atypical CPP, 2 choroid plexus carcinomas (CPCs), 5 anaplastic ependymomas, 7 nonanaplastic ependymomas (simply referred to as "ependymoma"), 5 medulloblastomas, 1 cerebral neuroblastoma, and 1 atypical teratoid/rhabdoid tumor (ATRT) along with 10 non-neoplastic choroid plexus and 3 non-neoplastic ependymal linings. " 01/01/2022 - "Postoperative histopathological types include ependymoma, pilocytic astrocytoma, choroid plexus papilloma (CPP), craniopharyngioma, primitive neuroectoderm tumor (PNET), choroid plexus carcinoma (CPC), immature teratoma, atypical teratoid rhabdoid tumor (AT/RT), anaplastic astrocytoma, and gangliocytoma. "
10.	beta CateninIBA 03/01/2011 - "Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma." 08/01/2004 - "These results suggest that expression of E-cadherin is useful for the differential diagnosis of atypical teratoma/rhabdoid tumor and medulloblastoma, and the expression of N-cadherin or beta-catenin may be related to the biological behavior of medulloblastomas." 08/01/2004 - "E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor." 03/01/2008 - "Discussion concentrates on the use of 4 antibodies: BAF47 in the diagnosis of atypical teratoid/ rhabdoid tumor, OCT4 in intracranial germinoma, beta-catenin in craniopharyngioma, and NeuN as a marker of neuronal differentiation in neuroepithelial neoplasms."

Therapies and Procedures

1.	Therapeutics 12/01/2019 - "Trimodality therapy for atypical teratoid/rhabdoid tumor is associated with improved overall survival: A surveillance, epidemiology, and end results analysis." 01/01/2019 - "Long-Term Remission of a Spinal Atypical Teratoid Rhabdoid Tumor in Response to Intensive Multimodal Therapy." 01/01/2023 - "Focal versus craniospinal radiation for disseminated atypical teratoid/rhabdoid tumor following favorable response to systemic therapy." 01/01/2022 - "Relapsing cerebral atypical teratoid/rhabdoid tumor after trimodality therapy: A case report: Erratum." 01/01/2022 - "The Impact of Surgical Resection and Adjuvant Therapy on Survival in Pediatric Patients with Atypical Teratoid/Rhabdoid Tumor: Systematic Review and Pooled Survival Analysis."
2.	Drug Therapy (Chemotherapy) 10/01/2020 - "Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333." 01/01/2023 - "Prolonged remission achieved with maintenance intraventricular chemotherapy in young patient with recurrent atypical teratoid rhabdoid tumor." 08/01/2023 - "A male newborn affected by atypical teratoid rhabdoid tumor, diagnosed prenatally, received two cycles of chemotherapy following surgical resection. " 07/01/2022 - "We report a case of a sellar atypical teratoid/rhabdoid tumor in a 70-year-old female treated with intraventricular chemotherapy, followed by a systematic review of the current management of sellar AT/RTs. " 01/01/2017 - "Sustained Complete Response to Metronomic Chemotherapy in a Child with Refractory Atypical Teratoid Rhabdoid Tumor: A Case Report."
3.	Radiotherapy 01/01/2023 - "Radiotherapy (RT) is associated with improved survival in atypical teratoid/rhabdoid tumor (ATRT); however, optimal RT delivery is unknown. " 07/01/2023 - "The role of postoperative radiotherapy (PORT) in children with primary intracranial atypical teratoid/rhabdoid tumor (AT/RT) remains controversial, and real-world data with large sample size are still lacking. " 01/01/2019 - "Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor." 09/01/2012 - "Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis." 01/01/2007 - "Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy."
4.	Combined Modality Therapy 08/25/2023 - "Survival Benefit from Multimodal Treatment for Patients with Atypical Teratoid Rhabdoid Tumor in a Surveillance, Epidemiology and End Result Database Analysis." 02/01/2020 - "Overall Survival of Primary Intracranial Atypical Teratoid Rhabdoid Tumor Following Multimodal Treatment: A Pooled Analysis of Individual Patient Data." 01/01/2018 - "Multimodal treatments combined with gamma knife surgery for primary atypical teratoid/rhabdoid tumor of the central nervous system: a single-institute experience of 18 patients." 06/01/2013 - "Despite intensifying multimodal treatments, children with central nervous system atypical teratoid/rhabdoid tumor (CNS ATRT) continue to endure unacceptably high mortality rates. " 06/01/2003 - "Cerebral atypical teratoid/rhabdoid tumor of infancy: long-term survival after multimodal treatment, also including triple intrathecal chemotherapy and gamma knife radiosurgery--case report."
5.	Ventriculoperitoneal Shunt 08/01/2001 - "To our knowledge there is only one report with an atypical teratoid rhabdoid tumor metastasizing via a ventriculoperitoneal shunt. " 01/01/2006 - "Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter." 01/01/2017 - "Here we report a case of symptomatic ascites in a young child with a ventriculoperitoneal shunt and metastatic atypical teratoid rhabdoid tumor. " 05/01/1999 - "A 4-year-old girl with a ventriculoperitoneal shunt metastasis of a central nervous system atypical teratoid/rhabdoid tumor."