Combined Modality Therapy

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

Also Known As:

Networked: 2381 relevant articles (227 outcomes, 299 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Minsky, Bruce D: 33 articles (04/2014 - 02/2002)
2.	Arnold, L Eugene: 18 articles (01/2015 - 05/2002)
3.	Guillem, Jose G: 16 articles (08/2012 - 02/2002)
4.	Hechtman, Lily: 15 articles (03/2013 - 05/2002)
5.	Jensen, Peter S: 15 articles (03/2013 - 05/2002)
6.	Wong, W Douglas: 15 articles (08/2012 - 02/2002)
7.	Hinshaw, Stephen P: 14 articles (01/2015 - 01/2002)
8.	Hoza, Betsy: 14 articles (03/2013 - 02/2002)
9.	Paty, Philip B: 13 articles (08/2012 - 08/2003)
10.	Choy, Hak: 13 articles (06/2012 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2014 - "Advancements in radiation therapy, chemotherapy, surgery, and multimodal treatment have dramatically improved childhood cancer survival. " 02/01/2011 - "Given the lack of improvement in overall survival, continued investigation is needed to identify the cohort of pT3b patients at highest risk for cancer progression and therefore most likely to benefit from a multimodal treatment approach." 07/01/2008 - "Although most patients with anal canal cancer are cured with sphincter-preserving, nonsurgical, combined-modality therapy, those with large tumors and lymph node involvement have a poor prognosis. " 12/01/2001 - "Because the long-term survival of children with cancer has dramatically improved because of multimodal treatment strategies, intensive care medicine has become more relevant for these patients. " 06/01/1999 - "With the consistent use of effective multimodal treatment, including combination chemotherapy, surgery and radiotherapy, the prognosis for all types of childhood cancer has dramatically improved over the last 25 years and the current 5-year survival rate is about 60-98%. "
2.	Hodgkin Disease (Hodgkin's Disease) 07/01/2010 - "Primary treatment for classic Hodgkin lymphoma (HL) remains highly effective with chemotherapy alone or combined-modality therapy. " 09/01/1977 - "The use of combined modality therapy (irradiation and combinations of drugs) in the treatment of Hodgkin's disease has produced a significant improvement in survival, during which most patients lead an active and productive life. " 10/01/2010 - "Depending on stage and risk factor profile, up to 95% of patients with Hodgkin lymphoma at first presentation reach complete remission after the initial standard treatment including radiotherapy, combination chemotherapy or combined modality therapy. " 03/19/1996 - "In patients with Hodgkin's disease presenting with massive mediastinal involvement the efficacy of combined modality therapy has been proven by all research groups. " 01/15/1985 - "Combined modality therapy was used in an attempt to increase the complete remission rate and survival of previously untreated patients with Hodgkin's disease. "
3.	Neoplasm Metastasis (Metastasis) 05/01/1997 - "The multimodal treatment including gamma-knife radiosurgery has produced complete remission of multiple brain metastases for 21 months with good quality of life. " 11/01/2006 - "Despite improved survival with combined modality therapy, local-regional recurrences and the development of distant metastases are still problematic. " 02/01/1998 - "Two thirds of the patients were diagnosed in stage II or III. Even patients with distant metastases can be cured with multimodal treatment: surgery, chemotherapy and radiotherapy. " 01/01/2015 - "This study was set up to determine the incidence of brain metastases and to investigate the outcome following multimodal treatment in 70 patients with LCNEC. " 02/01/2013 - "Thus, there is certainly a role for surgeons in patients with minimal peritoneal metastasis, both in clinical practice and in clinical trials where multimodal treatment strategies including surgery are to be explored. "
4.	Rectal Neoplasms (Rectal Cancer) 08/01/2006 - "A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography." 07/01/2003 - "Despite the routine use of adjuvant chemoradiation for curatively resected stage II and III rectal cancer a significant percentage of patients ultimately fail locally and/or distally; this underscores the need for continued improvement in the efficacy of combined-modality therapy and quality of rectal cancer resection. " 09/01/1988 - "Combined modality therapy is a safe and effective regimen for those rectal tumors in the high risk category." 01/01/2004 - "Studies have supported the use of combined modality therapy as standard adjuvant care for clinical T3 rectal cancer in the preoperative setting and for patients with T3 and/or N1/N2 disease in the postoperative setting, wtih improved rates of sphincter preservation, recurrence and overall survival." 08/01/2005 - "These results suggest that FDG-PET is superior to CT and MRI in predicting response to preoperative multimodal treatment of locally advanced primary rectal cancer."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/01/2013 - "Clinical trials incorporating immunomodulatory agents into combined modality therapy of locally advanced non-small cell lung cancer have shown promising results. " 03/01/1999 - "Over the past few years there have been numerous schedules of combined modality therapy proposed as being useful in the management of inoperable non-small cell lung cancer (NSCLC). " 10/01/1998 - "Combined modality therapy for non-small-cell lung cancer (NSCLC) has produced promising results. " 05/01/2002 - "Locally advanced or unresectable stage III non-small-cell lung cancer (NSCLC) patients treated with combined-modality therapy with chemotherapy plus thoracic radiation have improved survival compared to those treated with radiotherapy alone. " 03/01/2001 - "Recently, combined modality therapy has improved outcome in other subsets of locally advanced non-small cell lung carcinoma. "

Related Drugs and Biologics

1.	pemetrexed (MTA)
2.	Methotrexate (Mexate)
3.	Non-alcoholic Fatty Liver Disease
4.	Paclitaxel (Taxol)
5.	Cisplatin (Platino)
6.	Doxorubicin (Adriamycin)
7.	Bleomycin (Blenoxane)
8.	Proteins (Proteins, Gene)
9.	Cytostatic Agents
10.	Alprostadil (Muse)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Intra-Arterial Infusions
5.	Adjuvant Chemotherapy