Atopic Dermatitis (Atopic Eczema)

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5279 relevant articles (486 outcomes, 821 trials/studies) found for this Disease

Description: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Also Known As:

Atopic Eczema; Dermatitis, Atopic; Atopic Dermatitides; Atopic Neurodermatitides; Atopic Neurodermatitis; Dermatitides, Atopic; Disseminated Neurodermatitides; Disseminated Neurodermatitis; Infantile Eczema; Neurodermatitides, Atopic; Neurodermatitides, Disseminated; Eczema, Atopic; Eczema, Infantile; Neurodermatitis, Atopic; Neurodermatitis, Disseminated

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 449

Inborn Genetic Diseases: 578

Genetic Skin Diseases: 11

Atopic Dermatitis: 5279

Skin and Connective Tissue Diseases

Skin Diseases: 6187

Dermatitis: 4234

Atopic Dermatitis: 5279

Eczematous Skin Diseases: 15

Atopic Dermatitis: 5279

Genetic Skin Diseases: 11

Atopic Dermatitis: 5279

Immune System Diseases: 1319

Hypersensitivity: 37871

Immediate Hypersensitivity: 1282

Atopic Dermatitis: 5279

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris)
2.	Skin Diseases
3.	Pruritus (Itching)
4.	Asthma (Bronchial Asthma)
5.	Dermatitis

Experts

1.	Reitamo, S: 15 articles (09/2008 - 08/2000)
2.	Boguniewicz, Mark: 14 articles (07/2008 - 01/2002)
3.	Czarnecka-Operacz, Magdalena: 14 articles (12/2006 - 01/2003)
4.	McLean, W H Irwin: 13 articles (06/2008 - 04/2006)
5.	Eichenfield, Lawrence F: 13 articles (05/2008 - 04/2002)
6.	Silny, Wojciech: 13 articles (12/2006 - 03/2004)
7.	Leung, Donald Y M: 12 articles (07/2008 - 01/2002)
8.	Novak, Natalija: 12 articles (12/2007 - 10/2002)
9.	Kapp, A: 11 articles (09/2008 - 06/2000)
10.	Nakamura, Koichiro: 11 articles (08/2008 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atopic Dermatitis:

1.	Tacrolimus (Prograf)FDA Link 06/01/2001 - "Tacrolimus (FK506) ointment showed remarkable efficacy against atopic dermatitis in animal models and clinical trials. " 07/01/2008 - "BACKGROUND: The proportion of dendritic cell subpopulations in the skin is important for the severity of atopic dermatitis because topical treatment with tacrolimus leads to rapid depletion of inflammatory dendritic epidermal cells, whereas Langerhans cells (LCs) predominate in cured sites. " 05/01/2007 - "BACKGROUND: Tacrolimus applied locally is a non-steroid anti-inflammatory drug with proven efficacy in atopic dermatitis. " 07/01/2006 - "OBJECTIVES: In view of its strong association with atopic dermatitis, the objective of this open-label study was to assess the efficacy and safety of tacrolimus ointment in the treatment of PA compared with the efficacy of moisturizers. " 09/01/2005 - "RESULTS: At the end of study, 50.6% (80 of 158) of the patients were treated successfully with tacrolimus ointment based on Investigators' Global Atopic Dermatitis Assessment scores, a significant improvement compared with patients treated with vehicle ointment (25.8% [41 of 159]). " Order ALL the reference details at left...
2.	pimecrolimus (Elidel)FDA Link 01/01/2006 - "Pimecrolimus cream 1% has proven to be well tolerated, safe, and highly effective in clinical studies in patients with atopic dermatitis." 10/01/2007 - "BACKGROUND: Pimecrolimus cream 1% has proven to be well-tolerated and effective in controlled clinical studies in patients with atopic dermatitis (AD). " 04/01/2006 - "CONCLUSION: The present study demonstrates that the good efficacy and tolerability of pimecrolimus ointment which had been shown in controlled trials: i) could also be demonstrated on a very large cohort of patients with atopic dermatitis when used in the outpatient setting, and ii) were paralleled by a significant improvement in the quality of life." 10/01/2005 - "In multiple clinical trials comprising more than 19,000 patients, pimecrolimus cream has been shown to be very effective in suppressing atopic dermatitis and to have an excellent safety profile. " 11/01/2004 - "CONCLUSION: Pimecrolimus cream 1% was well tolerated and effective in patients with mild to very severe atopic eczema, with rapid onset of action and no disease rebound after discontinuation." Order ALL the reference details at left...
3.	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/01/1992 - "BACKGROUND: In previous studies, oral cyclosporine was highly effective in the treatment of patients with severe atopic dermatitis. " 09/01/2007 - "Although cyclosporin A treatment is highly efficacious and relatively safe, we report four adult atopic dermatitis (AD) patients who deteriorated during long-term cyclosporin A treatment, with clinical signs and symptoms more severe than at the onset of treatment. " 01/01/2000 - "Cyclosporin (CyA) has been shown to be highly effective and well tolerated in the short-term treatment of severe childhood atopic dermatitis; however, there is limited experience in its longer-term use. " 01/01/1999 - "BACKGROUND: Cyclosporin A (CsA) has been shown to be highly effective in the therapy of atopic dermatitis (AD). " 04/01/2002 - "During the last decade, oral cyclosporin (CsA) has proven to be effective, in randomized controlled trials, for the treatment of atopic dermatitis (AD) in human patients. " Order ALL the reference details at left...
4.	Immunoglobulin E (IgE)IBA 01/01/2002 - "The combination of the local disinfection therapy against Staphylococcus aureus with the conventional therapy for atopic dermatitis has been widely used, and the improvement in skin lesions has been reported to be associated with a remarkable decrease in IgE levels and reagin antibody titers. " 07/01/1987 - "Studies performed on patients with atopic dermatitis have shown high IgE levels, eosinophils and T4 counts, and a marked decrease in T8 suppressor cells in peripheral blood. " 10/01/1995 - "In both groups, atopic eczema improved significantly and progressively, and a downward trend was found in serum total and milk-specific IgE concentrations, proving the efficacy of both formulas. " 12/01/1983 - "Six of seven patients with moderate to severe atopic dermatitis and IgE levels of 1339 to 24,261 IU/ml had less than 0.1% T epsilon cells and significantly fewer T gamma cells (3.1% +/- 2.7, p less than 0.01) than the nonatopic control donors and the atopic donors in remission. " 12/01/2004 - "In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model." Order ALL the reference details at left...
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2005 - "Controlled clinical studies have provided strong evidence that moisturizers not only enhance the efficacy of topical corticosteroids in patients with atopic dermatitis but also may prevent disease reexacerbation. " 01/01/2005 - "Clinical data show that TIMs are effective in atopic dermatitis, yet do not cause the significant adverse effects associated with topical corticosteroids. " 01/01/2005 - "BACKGROUND: Topical corticosteroids remain the mainstay of treatment for atopic eczema, yet there is uncertainty over the frequency of their use in terms of clinical and cost effectiveness. " 12/01/2003 - "AIMS: To determine whether "herbal creams" reported as being effective for the treatment of childhood atopic eczema contained corticosteroids. " 09/01/2003 - "Topical corticosteroids are the mainstay of treatment for atopic dermatitis; however, their clinical utility is limited by potential side effects. " Order ALL the reference details at left...
6.	AntigensIBA 01/01/2000 - "SELECTION CRITERIA: All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating mothers of infants with atopic eczema, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. " 01/01/1996 - "SELECTION CRITERIA: All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating mothers of infants with atopic eczema, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. " 01/01/1984 - "The efficacy of an antigen-free diet on the activity of atopic dermatitis was examined in a double-blind study, comprising 33 adults with severe atopic dermatitis. " 01/01/2006 - "Prescription of an antigen avoidance diet to a high-risk woman during lactation may reduce her child's risk of developing atopic eczema, but better trials are needed. " 01/01/2006 - " evidence from one trial, involving 26 participants, did not observe a significant protective effect of maternal antigen avoidance during lactation on the incidence of atopic eczema during the first 18 months.One" Order ALL the reference details at left...
7.	Dust (House Dust)IBA 04/01/2008 - "Collectively, these results demonstrated extensive in vitro cross-reactivity among house dust and/or storage mites that can explain false-positive results upon testing of dust mite-sensitive dogs with atopic dermatitis." 10/01/1997 - "As a conclusion, vacuum cleaning of the patient's room improved the clinical symptoms of atopic dermatitis but this could not be related to the reduction of house dust mite number." 01/01/1989 - "Six out of 17 patients with atopic dermatitis in remission had positive delayed type reactions to birch pollen and three to house dust mite. " 07/01/1985 - "Remission of life-long atopic dermatitis after hyposensitisation to house dust mite." 08/01/2002 - "We investigated the effect of house dust mite (HDM)-allergen avoidance on the development of respiratory symptoms, atopic dermatitis, and atopic sensitization by performing a double blind, placebo-controlled trial. " Order ALL the reference details at left...
8.	Hydrocortisone (Cortisol)FDA LinkGeneric 05/01/2007 - "Of the subjects who completed the study with complications in cortisol testing (n=3), there was one subject (1/37=3%) who had a low poststimulation cortisol level at week 4. Efficacy was demonstrated by marked improvement in overall disease state and in the signs and symptoms of atopic dermatitis. " 01/01/1995 - "Comparative efficacy of hamamelis distillate and hydrocortisone cream in atopic eczema." 01/01/1988 - "Percutaneous absorption of hydrocortisone during exacerbation and remission of atopic dermatitis in adults." 04/01/2003 - "METHODS: Three separate studies were performed in children aged 2 to 12 years with atopic dermatitis: multicenter double-blind, randomized, and vehicle-controlled trial; cortisol stimulation testing; and prick testing, patch testing, and monitored medication use in children with peanut allergic sensitivity. " 01/01/1995 - "In a double-blind, randomized, paired trial lasting 14 days in 72 patients with moderately severe atopic eczema, hamamelis distillate cream (5.35 g hamamelis distillate with 0.64 mg ketone/100 g) was compared with the corresponding drug-free vehicle and 0.5% hydrocortisone cream, and reductions of the basic criteria of severe atopic eczema (delta values of the sum scores), i.e. " Order ALL the reference details at left...
9.	CalcineurinIBA 06/01/2006 - "The introduction of topical calcineurin inhibitors resulted in a significant improvement in the treatment of atopic dermatitis. " 01/01/2005 - "In several clinical studies of children and adults with atopic dermatitis, topical calcineurin inhibitors were found to be effective both on the face and the trunk and extremities, in both short- and long-term treatment regimens. " 10/01/2004 - "BACKGROUND: In several clinical studies, topical calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis (AD). " 11/01/2006 - "SUMMARY OF THE FINDINGS: The data showed that calcineurin inhibitors are efficient in the treatment of mild to severe atopic dermatitis, leading to improvement in symptoms, reduction in number of attacks and need of topical corticotherapy. " 05/01/2006 - "New drugs such as the topical calcineurin inhibitors have shown promise in treating mild-to-severe atopic dermatitis. " Order ALL the reference details at left...
10.	AllergensIBA 01/01/2005 - "Other studies are warranted to assess the interest and efficacy of eviction of inhalant allergens in atopic dermatitis." 01/01/2005 - "Positive results of atopy patch test with airborne allergens were obtained in 47.2% of atopic dermatitis patients and none of control subjects. " 07/01/1982 - "All allergens suspected of being implicated in the genesis of atopic dermatitis were eliminated from the diet. " 01/01/2009 - "The study group included 154 children (their age varied from 6 months to 18 years) with atopic dermatitis, for whom food allergens were determined by allergic skin tests (skin prick and patch). " 09/01/2008 - "METHODS: Seventy five subjects with atopic dermatitis were included in our study and patch tests using prick test allergens were applied to the back. " Order ALL the reference details at left...

Therapies and Procedures

1.	Phototherapy (Light Therapy) 12/01/2004 - "UVA1 phototherapy is highly effective in the treatment of moderate to severe atopic dermatitis and sclerosing diseases of the skin. " 04/01/1998 - "BACKGROUND: The results of an open, single-center study suggested that phototherapy with high doses of UVA1 radiation (UVA1R; 340-400 nm) is effective for acute, severe exacerbations of atopic dermatitis (AD). " 10/01/2001 - "OBJECTIVE: Our purpose was to compare the efficacy of high-dose with medium-dose UVA1 phototherapy for patients with severe generalized atopic dermatitis. " 02/01/2000 - "RESULTS: Medium-dose UVA1 phototherapy is effective for alleviating acute exacerbated atopic dermatitis as shown by a significant reduction of SCORAD ratings (P <.001) at the end of the active UV treatment period. " 12/01/1998 - "There is evidence that phototherapy in atopic dermatitis may be even more effective when combined with anti-staphylococcal measurements. " Order ALL the reference details at left...
2.	Immunotherapy 12/01/2007 - "Double-blind placebo-controlled studies on the safety and efficacy of subcutaneous and sublingual specific immunotherapy in atopic dermatitis are rare; however, a systematic review of the literature on all published studies on specific immunotherapy in atopic dermatitis, together with the results of the most recent controlled studies, provides promising results. " 09/01/2006 - "Additionally, the efficacy of subcutaneous immunotherapy has been demonstrated in patients with atopic dermatitis, although more double-blind, placebo-controlled studies are needed. " 06/01/2003 - "The efficacy of pharmacological interventions used to treat canine atopic dermatitis, excluding fatty acid supplementation and allergen-specific immunotherapy, was evaluated based on the systematic review of prospective clinical trials published between 1980 and 2002. " 01/01/2005 - "[Efficacy of specific immunotherapy in the treatment of children and youngsters suffering from atopic dermatitis. " 05/01/1994 - "[The efficacy of long-term specific immunotherapy for Dermatophagoides pteronyssinus in patients with atopic dermatitis]" Order ALL the reference details at left...
3.	Skin Care 03/01/2009 - "Skin care with daily showering at an elementary school was thus found to be effective for the treatment of atopic dermatitis." 08/01/2009 - "PURPOSE OF REVIEW: The authors discuss the role of moisturizers in the daily skin care regimen of healthy skin and in atopic dermatitis, as well as the efficacy of newer products. " 01/01/1997 - "These results suggest that remission of adult-type refractory atopic dermatitis can be achieved by the combination of careful daily skin care, use of non-steroidal topical ointment and minimizing the precipitating factors." 02/01/2009 - "PURPOSE OF REVIEW: To discuss the significance of studies published over the previous year regarding the pathogenesis and treatment of atopic dermatitis, including prevention, skin care, environmental modifications, nutrition, education, and anti-inflammatory medications. " 01/01/2008 - "CONCLUSION: This study showed substantial relief of objective and subjective symptoms of atopic eczema after regular skin care with the study cream. " Order ALL the reference details at left...
4.	Oral Administration 02/01/2002 - "Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga." 08/01/2009 - "The oral administration of the quince HW-added diet to NC/Nga mice for 63 d showed a significant decrease in the development of atopic dermatitis-like skin lesions under conventional conditions. " 03/01/2008 - "Prophylactic effect of oral administration of Lactobacillus johnsonii NCC533 (La1) during the weaning period on atopic dermatitis in NC/NgaTnd mice." 06/01/2007 - "Oral administration of the extract from Hatakeshimeji (Lyophyllum decastes sing.) mushroom inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice." 04/01/2006 - "We studied the development of atopic dermatitis-like skin lesions in NC/Nga mice and the allergic symptoms and blood patterns of healthy volunteers during the cedar (Cryptomeria japonica) pollen season in Japan following oral administration of a new synbiotic, Lactobacillus casei subsp. " Order ALL the reference details at left...
5.	Baths 10/01/2008 - "We also discuss new treatment strategies that are being used by atopic dermatitis specialists, such as comprehensive "education-as-intervention" models, wet wraps, bleach baths, and systemic immunomodulatory therapies." 06/01/2008 - "It also includes specialized topical treatment strategies for AD, such as wet wraps and diluted bleach baths, and highlights the most common challenges to patient compliance in atopic dermatitis." 05/01/1975 - "[Evaluation of treatment of atopic dermatitis with salt baths]" 10/01/2000 - "The combination of seawater baths and solar radiation at the Dead Sea is known as an effective treatment for patients with psoriasis and atopic dermatitis. " 03/01/1999 - "The combination of salt water baths and solar radiation is known as an effective treatment for patients with psoriasis and atopic dermatitis. " Order ALL the reference details at left...

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