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The effect of topically applied corticosteroids on interleukin 1β levels in patients with atopic dermatitis.

AbstractBACKGROUND:
Atopic dermatitis (AD) is a chronic recurrent disease of childhood. The therapeutics of AD needs to be more tailored given the new cytokine antibodies available. In this scenario we considered interleukin 1 beta (IL-1β) levels before and after therapy with topical corticosteroids.
OBJECTIVES:
To measure the IL-1β levels before and after treatment in patients with AD after 75% improvement in scoring for atopic dermatitis index.
METHODS:
Forty-five subjects with AD were treated with betamethasone ointment and their IL-1β level was measured prior to and following treatment.
RESULTS:
The IL-1β levels were raised during disease activity and following improvement they decreased in a statistically significant manner. Also the IL-1β levels corresponded with the severity of disease activity.
CONCLUSIONS:
Newer modalities of therapy in the form of cytokine monoclonal antibodies should be studied in a larger scale in AD.
AuthorsF N U Nutan, A J Kanwar, D Parsad
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 26 Issue 8 Pg. 1020-2 (Aug 2012) ISSN: 1468-3083 [Electronic] England
PMID21623929 (Publication Type: Journal Article)
Copyright© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.
Chemical References
  • Adrenal Cortex Hormones
  • Interleukin-1beta
Topics
  • Administration, Topical
  • Adrenal Cortex Hormones (administration & dosage)
  • Dermatitis, Atopic (blood)
  • Humans
  • Interleukin-1beta (blood)

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