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High-dose UVA1 therapy for atopic dermatitis: results of a multicenter trial.

AbstractBACKGROUND:
The results of an open, single-center study suggested that phototherapy with high doses of UVA1 radiation (UVA1R; 340-400 nm) is effective for acute, severe exacerbations of atopic dermatitis (AD).
OBJECTIVE:
The purpose of this study was to assess the effectiveness of high-dose UVA1 phototherapy for acute, severe AD in a randomized multicenter trial in direct comparison with topical glucocorticoid therapy.
METHODS:
Patients were treated with high-dose UVA1R (10 days, 130 J/cm2/day; n = 20), topically with fluocortolone (10 days, 1 x daily; n = 17), or with UVA-UVB therapy (10 days, 1 x daily, minimal erythema dose-dependent; n = 16).
RESULTS:
With a clinical scoring system, significant differences in favor of high-dose UVA1R and fluocortolone therapy were observed (p < 0.0001), as compared with UVA-UVB therapy. At day 10, high-dose UVA1R was superior to fluocortolone (p < 0.002) therapy. Serum levels of eosinophil cationic protein and the blood eosinophil count were significantly reduced after high-dose UVA1 or fluocortolone, but not UVA-UVB therapy.
CONCLUSION:
This study confirms the therapeutic effectiveness of high-dose UVA1 monotherapy for treatment of severe exacerbations of AD.
AuthorsJ Krutmann, T L Diepgen, T A Luger, S Grabbe, H Meffert, N Sönnichsen, W Czech, A Kapp, H Stege, M Grewe, E Schöpf
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 38 Issue 4 Pg. 589-93 (Apr 1998) ISSN: 0190-9622 [Print] United States
PMID9555799 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Fluocortolone
Topics
  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Dermatitis, Atopic (drug therapy, radiotherapy)
  • Female
  • Fluocortolone (therapeutic use)
  • Glucocorticoids
  • Humans
  • Male
  • Radiotherapy Dosage
  • Ultraviolet Therapy (methods)

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