Abstract | BACKGROUND: The results of an open, single-center study suggested that phototherapy with high doses of UVA1 radiation (UVA1R; 340-400 nm) is effective for acute, severe exacerbations of atopic dermatitis (AD). OBJECTIVE: The purpose of this study was to assess the effectiveness of high-dose UVA1 phototherapy for acute, severe AD in a randomized multicenter trial in direct comparison with topical glucocorticoid therapy. METHODS: Patients were treated with high-dose UVA1R (10 days, 130 J/cm2/day; n = 20), topically with fluocortolone (10 days, 1 x daily; n = 17), or with UVA-UVB therapy (10 days, 1 x daily, minimal erythema dose-dependent; n = 16). RESULTS: CONCLUSION: This study confirms the therapeutic effectiveness of high-dose UVA1 monotherapy for treatment of severe exacerbations of AD.
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Authors | J Krutmann, T L Diepgen, T A Luger, S Grabbe, H Meffert, N Sönnichsen, W Czech, A Kapp, H Stege, M Grewe, E Schöpf |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 38
Issue 4
Pg. 589-93
(Apr 1998)
ISSN: 0190-9622 [Print] United States |
PMID | 9555799
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Glucocorticoids
- Fluocortolone
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Topics |
- Administration, Topical
- Adult
- Anti-Inflammatory Agents
(therapeutic use)
- Dermatitis, Atopic
(drug therapy, radiotherapy)
- Female
- Fluocortolone
(therapeutic use)
- Glucocorticoids
- Humans
- Male
- Radiotherapy Dosage
- Ultraviolet Therapy
(methods)
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