Abstract | BACKGROUND: OBJECTIVES: This study was designed to assess the clinical therapeutic effect of persimmon leaf extract and astragalin in NC/Nga mice suffering from dermatitis and the dose-response preventive effects of persimmon leaf extract on dermatitis and transepidermal water loss (TEWL). METHODS: The efficacy of persimmon leaf extract or astragalin in NC/Nga mice was judged by measurement of skin severity, scratching behaviour, serum IgE levels or TEWL. RESULTS:
Oral administration of persimmon leaf extract (250 mg kg(-1)) or astragalin (1.5 mg kg-1) for 4 weeks into NC/Nga mice with overt dermatitis resulted in a decrease in the severity of the condition. The preventive effect of persimmon leaf extract on the dermatitis was dose-dependent and continuous intake of persimmon leaf extract significantly decreased its onset and development. In addition, TEWL was also suppressed at a persimmon leaf extract dose of 250 mg kg(-1). No significant adverse reaction by these substances could be observed. CONCLUSIONS: These observations suggest that persimmon leaf extract or the flavonoid astragalin may be alternative substances for the management of AD.
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Authors | M Matsumoto, M Kotani, A Fujita, S Higa, T Kishimoto, M Suemura, T Tanaka |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 146
Issue 2
Pg. 221-7
(Feb 2002)
ISSN: 0007-0963 [Print] England |
PMID | 11903231
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Flavonoids
- Kaempferols
- astragalin
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Topics |
- Administration, Oral
- Animals
- Dermatitis, Atopic
(drug therapy, pathology)
- Diospyros
(chemistry)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Drugs, Chinese Herbal
(therapeutic use)
- Flavonoids
(therapeutic use)
- Kaempferols
- Mice
- Mice, Inbred Strains
- Phytotherapy
(methods)
- Plant Leaves
(chemistry)
- Water Loss, Insensible
(drug effects)
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