HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Asthma (Bronchial Asthma)

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Also Known As:
Bronchial Asthma; Asthmas; Asthma, Bronchial
Networked: 85047 relevant articles (7121 outcomes, 16018 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation (Inflammations)
2. Chronic Obstructive Pulmonary Disease (COPD)
3. Allergic Rhinitis
4. Hypersensitivity (Allergy)
5. Rhinitis

Experts

1. Weiss, Scott T: 256 articles (09/2022 - 02/2002)
2. Szefler, Stanley J: 196 articles (12/2022 - 01/2002)
3. Busse, William W: 190 articles (11/2022 - 04/2002)
4. Castro, Mario: 185 articles (11/2022 - 04/2004)
5. Gibson, Peter G: 184 articles (12/2022 - 01/2002)
6. Barnes, Peter J: 183 articles (01/2022 - 01/2002)
7. Bleecker, Eugene R: 168 articles (11/2022 - 01/2002)
8. O'Byrne, Paul M: 160 articles (01/2022 - 01/2002)
9. Israel, Elliot: 158 articles (11/2022 - 03/2002)
10. Park, Choon-Sik: 158 articles (06/2022 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asthma:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2019 - "In 2004, the landmark Gaining Optimal Asthma Control (GOAL) study demonstrated that most patients can achieve asthma control through sustained treatment and that adding a long-acting β2-adrenoreceptor agonist to an inhaled corticosteroid (ICS) is more effective than ICS alone in this regard. "
08/01/2003 - "The significant findings of 17 selected, controlled clinical trials of oral corticosteroids (OCSs) for acute exacerbations of asthma in children, compared with placebo or with other formulations of corticosteroids, can be summarized as follows: 1) OCSs are effective for the outpatient treatment of acute asthma, 2) pulmonary function tests may not be the best means of assessing the efficacy of OCSs for acute asthma, 3) early administration of OCSs for acute asthma reduces hospitalizations, 4) the critical factor for a positive outcome is early administration of the corticosteroid, and 5) OCSs are preferred for the outpatient treatment of acute asthma. "
10/01/1998 - "This study aimed to determine whether the changes in practice in the management of asthma since the early 1980s have improved standards (as assessed by higher actual/best function) and reduced the need for oral corticosteroids. "
11/09/2023 - "There is uncertainty about the best treatment option for children/adolescents with uncontrolled asthma despite inhaled corticosteroids, and international guidelines make different recommendations. "
03/28/2023 - "Although effective for most individuals, older patients are more insensitive to corticosteroids, making it difficult to manage asthma in this population. "
2. Omalizumab (Xolair)FDA Link
3. SteroidsIBA
4. AllergensIBA
5. Budesonide (Pulmicort)FDA LinkGeneric
6. Bronchodilator Agents (Bronchodilators)IBA
7. Albuterol (Salbutamol)FDA LinkGeneric
8. Immunoglobulin E (IgE)IBA
01/01/2018 - "For diagnosis of baker's asthma, a whole wheat extract is still the best option for specific IgE determination. "
03/01/1999 - "This study suggests that (1) the percentage of CD4+, CD8+, or IL-2R+ lymphocytes in peripheral blood was significantly elevated during acute attacks and returned to normal ranges after complete remission was achieved; (2) plasma soluble IL-2R is a sensitive marker for asthma activity; and (3) atopic asthmatic children seem to have a hereditary predisposition of having higher levels of soluble IL-2R in asthma attacks, coinherited with the trait of IgE."
01/01/2012 - "Blood immunoglobulin E levels were significantly increased in the asthma group, and blood eosinophils were significantly elevated in the complete asthma remission, symptomatic remission and asthma groups compared with controls. "
07/01/2000 - "I have three objectives: (1) review T cell differentiation leading to the Th1/Th2 paradigm; (2) evaluate the increased prevalence of atopy, including asthma, as a consequence of a Th2-dominated immune system; (3) relate the high prevalence of asthma in inner city United States black children to the relatively recent migration of their ancestors from tropical regions of Africa, where genetically biased Th2-dependent IgE responses may be important in protection against high burdens of parasitic worms."
11/01/2021 - "The prevalence of CSU recurrence after a full remission is significantly higher among patients with existing bronchial asthma, increased levels of total IgE, and autoimmunity. "
9. montelukast (Singulair)FDA Link
10. Fluticasone (Cutivate)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Nebulizers and Vaporizers (Inhaler)
3. Immunotherapy
4. Drug Therapy (Chemotherapy)
5. Metered Dose Inhalers (Metered Dose Inhaler)