GluK2 Kainate Receptor

A high-affinity KAINATE and GLUTAMATE receptor that functions as ligand-gated ion channel in the CENTRAL NERVOUS SYSYEM and plays an essential role in NEURONAL PLASTICITY.

Also Known As:

Receptor, GluK2 Kainate; Receptor, GluR6; Receptor, GluR6 Kainate; Receptors, GluR6 Kainate; GluR6 Kainate Receptor; GluR6 Kainate Receptors; GluR6 Receptor; Ionotropic Glutamate Receptor GluR6

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Ligand-Gated Ion Channels: 221
        Ionotropic Glutamate Receptors: 394
        Kainic Acid Receptors: 314
        GluK2 Kainate Receptor: 10
        human GRIK2 protein
        mouse Grik2 protein
        rat Grik2 protein
  - Membrane Proteins: 10078

Experts

1.	Pei, Dong-Sheng: 2 articles (12/2010 - 12/2009)
2.	Fritsch, Brita: 1 article (04/2014)
3.	Gasior, Maciej: 1 article (04/2014)
4.	Kaminski, Rafal M: 1 article (04/2014)
5.	Reis, Janine: 1 article (04/2014)
6.	Rogawski, Michael A: 1 article (04/2014)
7.	Liu, Zhi-An: 1 article (12/2010)
8.	Xu, Jing: 1 article (12/2010)
9.	Xu, Tie-Jun: 1 article (12/2010)
10.	Li, Ting: 1 article (12/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/15/2002 - "The GluR6 kainate receptor gene GRIK2 is located on chromosome 6q16.3-q21, a schizophrenia susceptibility region, as suggested by multiple linkage studies. " 12/15/2002 - "Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia." 12/01/1996 - "Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia."
2.	Seizures (Absence Seizure) 12/01/2002 - "Furthermore, the activation of GluR5 and GluR6 kainate receptor subtypes by endogenous glutamate during seizures may be associated with the drug-resistance phenomenon." 04/23/2014 - "Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. "
3.	Huntington Disease (Huntington's Disease) 07/17/2003 - "To identify the genetic modifier(s) that might alter the age at onset in Huntington's disease (HD) we have analyzed variations in GluR6 kainate receptor (GluR6), CA150 gene, Delta2642 and polymorphic CCG repeat variation in huntingtin (htt) gene in 77 HD patients and normal individuals. " 04/15/1997 - "Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease."
4.	Brain Ischemia (Cerebral Ischemia) 12/01/2009 - "GluR6 kainate receptor subunit is largely expressed in hippocampus of brain regions and plays an important role in brain ischemia/reperfusion-mediated neuronal cell death. " 12/17/2010 - "Although recent results suggest that GluR6 serine phosphorylation plays a prominent role in brain ischemia/reperfusion-mediated neuronal injury, little is known about the precise mechanisms regulating GluR6 receptor phosphorylation. "
5.	Ischemia 06/30/2009 - "In contrast, both GluR6 antisense ODNs (oligodeoxynucleotides) and 6,7,8,9-tetrahydro-5-nitro-1 H-benz[g]indole-2,3-dione-3-oxime (NS102), an antagonist of GluR6 receptor, prevented the above effects of preconditioning, which shows that suppressing the expression of GluR6 or inhibiting GluR6 activity contributes negatively to preconditioning-induced ischemia tolerance. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Kainic Acid Receptors (Kainate Receptor)
3.	Serine (L-Serine)
4.	Propionates
5.	Oximes
6.	Oligodeoxyribonucleotides
7.	indole