Cell Surface Receptors

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552 relevant articles (8 outcomes, 27 trials/studies) found for this Bio-Agent

Description: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.

Also Known As:

Receptors, Cell Surface; Cell Surface Hormone Receptors; Endogenous Substances Receptors; Hormone Receptors, Cell Surface; Receptors, Endogenous Substances

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Membrane Proteins: 4125

Cell Surface Receptors: 552

Transferrin Receptors: 1077

Urokinase Plasminogen Activator Receptors: 485

G-Protein-Coupled Receptors: 428

folate-binding protein: 399

Peptide Receptors: 308

Death Domain Receptors: 305

Neurotransmitter Receptors: 284

Receptor Protein-Tyrosine Kinases: 252

Purinergic Receptors: 229

DC-specific ICAM-3 grabbing nonintegrin: 221

Autoreceptors: 199

Asialoglycoprotein Receptor: 176

Proteinase-Activated Receptors: 158

Collagen Receptors: 123

Lipoprotein Receptors: 112

intrinsic factor-cobalamin receptor: 34

receptors for activated C kinase: 34

netrin receptors: 33

extracellular matrix receptor: 32

glucose receptor: 29

protease nexins: 27

saccharide-binding proteins: 26

DNA receptor: 25

egg surface sperm receptor: 21

activated protein C receptor: 20

elastin-binding proteins: 18

CD150 antigen: 17

Frizzled Receptors: 17

glycolipid receptor: 14

sialic acid receptor: 14

Odorant Receptors: 12

vitellogenin receptor: 12

prorenin receptor: 10

galactose receptor: 9

lactoferrin receptors: 9

ganglioside receptor: 8

serpin-enzyme complex receptor: 8

DEC-205 receptor: 7

zona pellucida glycoproteins: 7

Immunologic Receptors: 6

Eicosanoid Receptors: 5

ferritin receptor: 5

heparin receptor: 5

carbon dioxide receptor: 4

epithelial membrane protein-1: 4

Biogenic Amine Receptors: 3

enterobactin receptor: 3

guanylate cyclase 1: 3

Guanylate Cyclase-Coupled Receptors: 3

neuronal pentraxin receptor: 3

peptidoglycan receptor: 3

Pheromone Receptors: 3

phosphatidylserine receptor: 3

thyroglobulin receptor: 3

urinary trypsin inhibitor receptor: 3

4-hydroxybutyric acid receptor: 2

heme receptor: 2

Phospholipase A2 Receptors: 2

retinol binding protein receptor: 2

sex hormone-binding globulin receptor: 2

sialyloligosaccharide receptor: 2

siderophore receptors: 2

Adipokine Receptors: 1

angiogenin receptor: 1

choleragen receptor: 1

forskolin receptor: 1

hemoglobin-haptoglobin receptor: 1

human PKHD1 protein: 1

N-Acetylglucosamine Receptors: 1

scFv-CD28-zeta chimeric receptor: 1

shigella toxin receptor: 1

surfactant protein A receptor: 1

transcobalamin receptor: 1

uridine triphosphate receptors: 1

2-iodomelatonin receptor

Agrobacterium radiobacter agrocin 84 receptor

Agrobacterium tumefaciens phenol receptor

Arabidopsis ACR4 protein

Arabidopsis AFB5 protein

Arabidopsis BRL1 protein

Arabidopsis BRL3 protein

Arabidopsis CRK5 protein

Arabidopsis DA1 protein

Arabidopsis EIN2 protein

Arabidopsis EIN4 protein

Arabidopsis ER protein

Arabidopsis ERS1 protein

Arabidopsis ETR1 protein

Arabidopsis ETR2 protein

Arabidopsis GID1a protein

Arabidopsis GID1b protein

Arabidopsis GID1c protein

Arabidopsis PEPR1 protein

Arabidopsis PR5K protein

Arabidopsis PSKR1 protein

Experts

1.	Martins, Paulo S: 1 article (01/2008)
2.	Machado, Flavia R: 1 article (01/2008)
3.	Assunçao, Murillo S: 1 article (01/2008)
4.	Blecher, Sergio: 1 article (01/2008)
5.	Martos, Leandro S W: 1 article (01/2008)
6.	Brunialti, Milena K C: 1 article (01/2008)
7.	Salomao, Reinaldo: 1 article (01/2008)
8.	Wakefield, Denis: 1 article (06/2006)
9.	Coroneo, Minas T: 1 article (06/2006)
10.	Di Girolamo, Nick: 1 article (06/2006)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2002 - "The permanent genetic programming via gene transfer of autologous T cells with cell surface receptors directed toward tumor-related Ags holds great promise for the development of more-specific tumor therapies. " 01/01/1996 - "RESULTS: Control Group concentrations of sIL-2R were in the range of 101.9 to 255.3 IU/mL with a mean value of 178.6 IU/mL. Serum levels of sIL-2R were markedly elevated in the sera of children with solid tumors (Study Group) to levels between 223.8 IU/mL and 927 IU/mL with a mean value of 575.4 IU/mL. CONCLUSIONS: 1) The shedding of cell-surface receptors of immunological effector cells is a common physiological mechanism; 2) Presence of sIL-2R represents a sign of an overall activation of the effector elements of the host's cellular immune system; 3) An increase in the levels of sIL-2R represents an active phase of progression; conversely, decreasing levels indicate tumor regression; 4) Serum levels of sIL-2Rs may represent a useful laboratory parameter in choosing an efficient anti-cancer therapy. " 01/01/1976 - "Integration of these diverse modes of MNB cell killing is of great interest because of the close resemblance of this murine tumor to human cancers in which cell differentiation is also partially membrane-mediated an indepth study of MNB cell surface receptors may have general relevance in the theoretical approach to cancer treatment." 10/15/2009 - "This superfamily of cell surface receptors have not, however, been widely considered as a viable target in cancer treatment. " 03/01/2009 - "Analyses of heritable and spontaneous types of human adrenocortical tumors documented alterations in either cell surface receptors or their downstream effectors that impact neoplastic transformation. " Order ALL the reference details at left...
2.	Lymphoma (Lymphomas) 07/01/1981 - "Eight spontaneous thymic lymphomas from AKR mice were characterized individually in vitro for cell surface receptors and mitogen reactivity. " 07/01/1981 - "Heterogeneity of cell surface receptors and mitogen reactivity of individual spontaneous AKR lymphomas." 05/22/1980 - "A prediction of the hypothesis is that T-lymphoma proliferation is dependent on continued presentation of MuLV envelope determinants to these cell-surface receptors, and that substances which interfere with receptor-virus interactions should inhibit T-lymphoma proliferation. " 05/01/1979 - "We conclude that the presence of specific cell surface receptors for lymphoma cell-produced and recombinant AKR retroviruses is a marker for leukemia in these hosts." 12/01/1995 - "The signal may be predictive of the efficacy of treatment with synthetic peptide ligands and may be useful in the evaluation of ligands for other cell surface receptors with biological effects on B-lymphoma cells." Order ALL the reference details at left...
3.	Melanoma (Melanoma, Malignant) 01/01/2007 - "Fluorescence microscopy is subsequently utilized to examine the targeting capabilities of peptide-amphiphile LUVs, which should allow for improved drug selectivity towards melanoma vs normal cells based on differences in the relative abundance of the targeted cell surface receptors." 06/01/1991 - "Human melanocyte strains and melanoma cell lines have been characterised with regard to levels of cell surface receptors of the integrin family. " 06/01/2005 - "CDK activity is sustained in melanoma cells mostly by the elimination of the CDK inhibitor p16INK4A and by high levels of cyclins whose expression is maintained by stimuli emanating from activated cell surface receptors and/or mutated intracellular intermediates, such as N-Ras and B-Raf. " 02/01/1976 - "Association of cell surface receptors for melanotropin with the Golgi region in mouse melanoma cells." 08/01/1997 - "The antibodies were used to target specific cell-surface receptors of the integrin type expressed by three human tumor cell lines, a melanoma (M21), and osteosarcoma (KRIB) and a fibroblastoma (WI-38). " Order ALL the reference details at left...
4.	Insulin Resistance 04/01/1995 - "Insulin resistance may occur at any level in the biologic action of insulin, from initial binding to cell surface receptors to the phosphorylation cascade that is initiated by autophosphorylation of the insulin receptor. " 11/01/1976 - "Autoantibodies directed against the cell surface receptors for insulin are found in some patients with extreme insulin resistance. " 12/01/1978 - "We conclude that (1) fat cells do not contribute to the insulin resistance of 10-wk obese Zucer rats since glucose utilization is higher in these cells at all concentrations of insulin tested, (2) obese Zucker rat soleus muscle metabolism is defective in two respects--imparied basal glucose utilization and a rightward shift in the insulin dose-response relationship with respect to hexose transport, and (3) this latter defect involving decreased sensitivity of muscle to insulin appears to result from a marked decrease in cell surface receptors for the hormone." Order ALL the reference details at left...
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/01/1989 - "The proliferative responsiveness to, production of, and the expression of cell-surface receptors for interleukin-2 (IL-2) were examined in 14 children with acute lymphoblastic leukemia (ALL) in remission and receiving maintenance chemotherapy for 6 to 35 months; in 19 children with ALL in remission and off all therapy for 2 to 138 months; and 15 control subjects. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Ligands
3.	Insulin (Novolin)
4.	Antibodies
5.	Hormones
6.	Interleukin-1 (Interleukin 1)
7.	Interleukin-2 (IL2)
8.	Cholinergic Agents (Cholinergics)
9.	Technetium (Technetium 99m)
10.	Deoxyglucose (2 Deoxy D glucose)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplants (Transplant)
4.	Therapeutics
5.	Ligation

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