Huntington Disease (Huntington's Disease)

3400  relevant articles (106 outcomes, 347 trials/studies) found for this Disease

Huntington's Disease; Huntington's Chorea; Progressive Chorea, Chronic Hereditary (Huntington); Chorea, Huntington; Chorea, Huntington's; Akinetic-Rigid Variant of Huntington Disease; Chorea, Chronic Progressive Hereditary (Huntington); Chronic Progressive Hereditary Chorea (Huntington); Huntington Chronic Progressive Hereditary Chorea; Huntington Disease, Akinetic-Rigid Variant; Huntington Disease, Juvenile; Huntington Disease, Juvenile-Onset; Huntington Disease, Late Onset; Juvenile-Onset Huntington Disease; Late-Onset Huntington Disease; Progressive Chorea, Hereditary, Chronic (Huntington); Akinetic Rigid Variant of Huntington Disease; Huntington Disease, Akinetic Rigid Variant; Huntington Disease, Juvenile Onset; Huntington Disease, Late-Onset; Juvenile Onset Huntington Disease; Late Onset Huntington Disease; Huntington Chorea; Juvenile Huntington Disease

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Dyskinesias (Dyskinesia)
3.	Chorea (Rheumatic Chorea)
4.	Stroke (Strokes)
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Ferrante, Robert J: 18 articles (09/2008 - 01/2002)
2.	Cattaneo, Elena: 18 articles (09/2008 - 09/2003)
3.	Hayden, Michael R: 17 articles (12/2007 - 03/2002)
4.	Bates, Gillian P: 14 articles (08/2007 - 05/2002)
5.	Leavitt, Blair R: 13 articles (10/2007 - 03/2002)
6.	Bonelli, Raphael M: 13 articles (04/2005 - 01/2002)
7.	Beal, M Flint: 11 articles (10/2007 - 01/2002)
8.	Dunnett, S B: 11 articles (01/2006 - 01/2000)
9.	Ross, Christopher A: 10 articles (06/2008 - 05/2002)
10.	Alberch, Jordi: 9 articles (10/2008 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Huntington Disease:

1.	polyglutamineIBA 05/01/2008 - "Using cellular and Drosophila models for Huntington's disease it was also shown that reduced ESCRT levels inhibit clearance of expanded polyglutamine aggregates and aggravate their neurotoxic effect. " 10/01/2006 - "During the past 5 years, gene expression studies in cell culture, animal models and in the brains of patients have shown that the perturbation of transcription frequently results in neuronal dysfunction in polyglutamine repeat diseases such as Huntington's disease. " 08/15/2002 - "The present study expands the regional and temporal scope of this previous work by assessing whether similar changes occur in other brain regions affected in Huntington's disease and other polyglutamine diseases and by discerning whether gene expression changes precede the appearance of disease signs. " 12/01/2009 - "The genetic mutation causing Huntington's disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by formation of toxic intracellular fragments, aggregates, and cell death. " 11/01/2009 - "The Huntington's disease (HD) mutation causes polyglutamine expansion in huntingtin (Htt) and neurodegeneration. " Order ALL the reference details at left...
2.	Minocycline (Cyclops)FDA LinkGeneric 12/01/2003 - "Minocycline is not beneficial in a phenotypic mouse model of Huntington's disease." 12/01/2003 - "Why minocycline is helpful in Huntington's disease." 12/01/2002 - "Maintained improvement with minocycline of a patient with advanced Huntington's disease." 11/01/2004 - "Neuroprotection in Huntington's disease: a 2-year study on minocycline." 03/11/2003 - "Minocycline for Huntington's disease: an open label study." Order ALL the reference details at left...
3.	Quinolinic AcidIBA 11/01/2000 - "Intrastriatal injection of quinolinate has been proven to be a very useful animal model to study the pathogenesis and treatment of Huntington's disease. " 12/01/2003 - "Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's disease." 03/16/1998 - "Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease." 06/01/2009 - "Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease." 04/01/2009 - "In a second experiment, migratory behavior was examined by transplanting cells a distance from a quinolinic acid-induced striatal lesion, a rat model for Huntington's disease. " Order ALL the reference details at left...
4.	gamma-Aminobutyric Acid (GABA)IBA 12/01/1980 - "In Huntington's chorea significant reduction in GABA content were observed in the nucleus accumbens, lateral pallidum, subthalamic nucleus, substantia nigra and ventrolateral thalamic nucleus. " 05/01/1983 - "We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. " 07/01/1980 - "Results of this trial neither support nor exclude the possible therapeutic usefulness of increasing brain GABA content in Huntington disease." 03/01/1979 - "Nevertheless, results are sufficiently promising to warrant further controlled trials of INH or other GABA-T inhibitors in Huntington disease." 12/15/2004 - "Huntington's disease (HD) is characterized by loss of striatal gamma-aminobutyric acid (GABA)ergic medium-sized spiny projection neurons (MSSNs), whereas some classes of striatal interneurons are relatively spared. " Order ALL the reference details at left...
5.	Genetic Markers (Genetic Marker)IBA 08/26/1989 - "Availability of new DNA markers, more tightly linked to the Huntington's disease (HD) locus than the original G8 (D4S10) probes, has improved predictive accuracy for both presymptomatic and prenatal exclusion testing. " 07/01/1987 - "These observations may prove helpful in the search for better genetic markers for Huntington's chorea, which maps close to D4S10." 01/01/2009 - "HD, the Huntington's disease gene, was the first autosomal defect mapped using only DNA markers, a finding in 1983 that helped to spur similar studies in many other disorders and contributed to the concept of the human genome project. " 11/01/1988 - "Improved predictive testing for Huntington disease by using three linked DNA markers." 06/01/1993 - "A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families." Order ALL the reference details at left...
6.	ethyl eicosapentaenoic acidIBA 12/01/2008 - "CONCLUSION: Ethyl-EPA was not beneficial in patients with Huntington disease during 6 months of placebo-controlled evaluation. " 01/21/2002 - "After 6 months all the patients treated with ethyl-EPA improved on the orofacial component of the Unified Huntington's Disease Rating Scale while all the patients on placebo deteriorated on this scale (p < 0.03). " 01/21/2002 - "MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment." 12/01/2008 - "Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study." 09/01/2008 - "High-resolution cerebral magnetic resonance imaging scans were acquired at baseline, 6 months and 1 year in up to 34 patients with stage I or II Huntington's disease who took part in a randomized, double-blind, placebo-controlled trial of ethyl-EPA. " Order ALL the reference details at left...
7.	TrehaloseIBA 01/01/2009 - "The present investigation examined the neuroprotective benefits for combined trehalose administration with C17.2 neural stem cell transplantation in a transgenic mouse model of Huntington's disease (HD), R6/2. C17.2 neural stem cells have the potential of differentiating into a neuronal phenotype in vitro and have been shown to be effective in the treatment of a variety of lysosomal lipid storage disorders in the nervous system. " 01/01/2009 - "Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease." 02/01/2004 - "Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease." 02/23/2007 - "Trehalose-induced autophagy enhanced the clearance of autophagy substrates like mutant huntingtin and the A30P and A53T mutants of alpha-synuclein, associated with Huntington disease (HD) and Parkinson disease (PD), respectively. " 01/01/2006 - "The chemical chaperone trehalose has been used effectively to alleviate symptoms in a mouse model of Huntington's disease and is thought to elicit its effect by binding and stabilizing partially folded polyglutamine proteins and inhibiting the formation of aggregates. " Order ALL the reference details at left...
8.	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/04/2007 - "It was the aim of this study to establish triglyceride matrices as potential carriers for long-term release of brain-derived neurotrophic factor (BDNF), a potential therapeutic for Huntington's disease. " 04/01/2008 - "Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice." 07/01/2009 - "Brain-derived neurotrophic factor (BDNF) deficiency has been implicated in pathogenesis of Huntington's disease (HD). " 06/01/2009 - "It is only in Huntington disease, however, that gain-of-function and loss-of-function experiments have linked BDNF mechanistically with the underlying genetic defect. " 03/24/2009 - "Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice." Order ALL the reference details at left...
9.	DNA (Deoxyribonucleic Acid)IBA 09/01/1998 - "A positive family history of Huntington's disease and DNA analysis helped to establish the diagnosis. " 01/01/2003 - "In an exploratory study we examined the impact, from the family's perspective, of predictive DNA testing for Huntington disease on the family as a system. " 03/01/2002 - "Predictive DNA-testing for Huntington's disease and reproductive decision making: a European collaborative study." 07/01/1995 - "The potential impact of DNA testing on asymptomatic subjects at risk for Huntington's disease (HD) has been addressed by numerous studies, but the effect of revealing the genetic results to patients with a clinically established diagnosis of HD has not been previously evaluated. " 11/01/1994 - "This study assessed the 6-month follow-up effects of presymptomatic DNA testing for Huntington's disease (HD) in 73 individuals at 50% prior risk who were identified either as carriers of the HD gene (N = 29) or as noncarriers (N = 44). " Order ALL the reference details at left...
10.	Proteins (Proteins, Gene)IBA 10/01/2005 - "These studies highlight the importance of dyneins and autophagy in the clearance of aggregate-prone proteins in general, and also in the specific case of Huntington's disease. " 07/06/2009 - "This study describes an assay for the detection of the intracellular mutant huntingtin, the causative agent of Huntington's disease, with a method that may be generally applicable to other cellular proteins. " 03/01/2004 - "Recent studies have identified several huntingtin-interacting proteins that might be associated with the normal function of huntingtin and/or involved in the pathology of Huntington's disease. " 03/01/2009 - "Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease." 01/01/2009 - "The search for these modifiers, much as the search for the HD gene did in the past, offers to open new entrées into the process of Huntington's disease pathogenesis by unlocking the biochemical changes that occur many years before diagnosis, and thereby providing validated target proteins and pathways for development of rational therapeutic interventions." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/1998 - "Fetal striatal transplantation may be as feasible, safe, and effective a treatment for Huntington's disease (HD), a disorder for which there is currently no effective treatment. " 04/01/2006 - "INTERPRETATION: Neuronal transplantation in Huntington's disease provides a period of several years of improvement and stability, but not a permanent cure for the disease. " 03/01/1996 - "Transplantation of human fetal striatum into a rodent model of Huntington's disease ameliorates locomotor deficits." 05/01/2002 - "Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. " 05/01/2000 - "In order to develop a surgical protocol for use in clinical trials of striatal transplantation in Huntington's disease (HD), the issues involved in the preparation and implantation of the embryonic striatal tissue must be addressed. " Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 07/01/2004 - "The woman was evaluated with the Unified Huntington's Disease Rating Scale before and after treatment. " 06/01/1997 - "We report a 56-year-old man with Huntington's disease whose chorea substantially improved after treatment with electroconvulsive therapy (ECT). " 01/08/1980 - "The author reports a case of Huntington's chorea improved after treatment with tiapride, and discusses the complex pathogenic features of this affection and the therapeutic difficulties encountered." 01/01/2006 - "All patients were treated with valproic acid and scored by using the Unified Huntington's Disease Rating Scale (UHDRS) motor score before and after treatment. " 01/01/1978 - "Four patients affected by Huntington's chorea (HC) with a well defined family history of the disease were injected intramuscularly with apomorphine hydrochloride in nonemetic doses, ranging from 1 to 4 mg. Soon after treatment, all patients showed a marked decrease in abnormal involuntary movements. " Order ALL the reference details at left...
3.	Transplants (Transplant) 04/01/2006 - "BACKGROUND: Although we have shown in three out of five patients with Huntington's disease that motor and cognitive improvements 2 years after intracerebral fetal neural grafts are correlated with recovery of brain metabolic activity in grafted striatal areas and connected regions of the cerebral cortex, neural grafts are not known to have protective effects on the host brain per se. " 04/01/2009 - "To date most studies have focused on rodent and primate models of Huntington's disease (HD) with demonstrations that transplants of CP can prevent the behavioral and anatomical consequences of striatal degeneration. " 04/01/2009 - "Potential of choroid plexus epithelial cell grafts for neuroprotection in Huntington's disease: what remains before considering clinical trials." 01/01/2007 - "This has led over the past fifteen years to the use of either short-term or even no immunosuppression in most clinical trials with foetal neural transplant in patients with Parkinson's and Huntington's disease. " 08/01/1999 - "Clinical trials of neural transplants in Huntington's disease patients are under way. " Order ALL the reference details at left...
4.	Homologous Transplantation (Allograft) 01/01/2000 - "This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. " 08/01/2008 - "Two patients with moderate Huntington's disease (HD) received bilateral fetal striatal allografts. " 01/01/2004 - "Foetal striatal allografts reverse these deficits in phenotypic models of Huntington's disease developed in primates. " 12/09/2000 - "INTERPRETATION: Fetal neural allografts could be associated with functional, motor, and cognitive improvements in patients with Huntington's disease." 01/01/2000 - "Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease." Order ALL the reference details at left...
5.	Oral Administration 01/01/1997 - "In other studies we found that oral administration of coenzyme Q10 significantly reduced increased concentrations of lactate in the occipital cortex of Huntington's disease patients. " 01/01/1999 - "Oral administration of CoQ10 significantly decreased elevated lactate levels in patients with Huntington's disease. " 02/01/2004 - "Oral administration of trehalose, the most effective of these disaccharides, decreased polyglutamine aggregates in cerebrum and liver, improved motor dysfunction and extended lifespan in a transgenic mouse model of Huntington disease. " 12/01/1978 - "The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). " Order ALL the reference details at left...