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Glutamate Receptors (Glutamate Receptor)

Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.
Also Known As:
Glutamate Receptor; Receptors, Glutamate; Excitatory Amino Acid Receptor; Receptor, Glutamate; Excitatory Amino Acid Receptors; Receptors, Excitatory Amino Acid
Networked: 1986 relevant articles (33 outcomes, 211 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Takahashi, Yukitoshi: 40 articles (04/2013 - 06/2003)
2. Meador-Woodruff, James H: 11 articles (06/2013 - 06/2003)
3. Javitt, Daniel C: 11 articles (09/2012 - 12/2002)
4. Worley, Paul F: 8 articles (10/2013 - 02/2005)
5. Lipton, Stuart A: 7 articles (04/2013 - 02/2002)
6. Zhang, Guang-Yi: 7 articles (04/2012 - 06/2005)
7. Vincent, Angela: 6 articles (09/2013 - 06/2003)
8. Haroutunian, Vahram: 6 articles (06/2013 - 06/2003)
9. McCullumsmith, Robert E: 6 articles (05/2013 - 11/2003)
10. Jensen, Frances E: 6 articles (12/2012 - 06/2002)

Related Diseases

1. Ischemia
2. Seizures (Seizure)
09/01/2009 - "The results of our coordinated electrophysiological, receptor-pharmacological and histoblot studies demonstrated that repeated, daily, short convulsions resulted in a significant decrease of the general excitability of the somatosensory cortex together with changes in ionotropic glutamate receptor subunits. "
04/10/2003 - "As glutamate receptors are thought to participate in seizure induction and the subsequent neuronal degeneration that ensues, previous studies have proposed that variation in the precise subunit composition of glutamate receptors may result in differential susceptibility to excitotoxic cell death. "
11/26/2001 - "The goal of this study was to determine the age of onset of cognitive dysfunction and alterations in seizure susceptibility in rats subjected to recurrent neonatal seizures and the relation of this cognitive impairment to mossy fiber sprouting and expression of glutamate receptors. "
12/11/1999 - "This study shows that PBN specifically protects against anticholinesterase-induced seizures by reversible protection of AChE activity and not by the blockade of muscarinic or glutamate receptors, reactivation of AChE or scavenging of ROS. "
07/01/2013 - "The observed differential transcriptional responses may contribute to early-life seizure-induced pre-conditioning and neuroprotection by reducing glutamate receptor-mediated Ca(2+) permeability of the hippocampus and redirecting inflammatory and apoptotic pathways. "
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3. Parkinson Disease (Parkinson's Disease)
4. Pain (Aches)
5. Brain Injuries (Brain Injury)

Related Drugs and Biologics

1. N-Methylaspartate (NMDA)
2. alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
3. Messenger RNA (mRNA)
4. Glutamic Acid (Glutamate)
5. AMPA Receptors (AMPA Receptor)
6. Dopamine (Intropin)
7. Amantadine (Aman)
8. Diazepam (Valium)
9. Kainic Acid (Kainate)
10. Dizocilpine Maleate (Dizocilpine)

Related Therapies and Procedures

1. Injections
2. Ligation
3. Intramuscular Injections
4. Oral Administration
5. Therapeutics

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