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Membrane Transport Proteins (Biological Pump)

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Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.

Also Known As:

Biological Pump; Permeases; Pump, Biological; Biological Pumps; Metabolic Pumps; Pump, Biologic; Pump, Metabolic; Pumps, Biological; Pumps, Metabolic; Biologic Pump; Transport Proteins, Membrane; Transporters, Membrane; Membrane Transporters; Metabolic Pump

Networked: 97 relevant articles (4 outcomes, 7 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58375
  - Carrier Proteins: 7715
    - Membrane Transport Proteins: 97
  - Membrane Proteins: 4076
    - Membrane Transport Proteins: 97

Experts

1.	Huang, Ying: 5 articles (04/2009 - 06/2004)
2.	Sadée, Wolfgang: 4 articles (04/2009 - 06/2004)
3.	Nies, Anne T: 3 articles (08/2007 - 11/2003)
4.	Giacomini, K M: 2 articles (01/2010 - 03/2007)
5.	Martin, Rowena E: 2 articles (11/2009 - 01/2005)
6.	Kirk, Kiaran: 2 articles (11/2009 - 01/2005)
7.	Lee, Tae-Bum: 2 articles (10/2009 - 01/2008)
8.	Choi, Cheol-Hee: 2 articles (10/2009 - 01/2008)
9.	Valdés, Raquel: 2 articles (07/2009 - 08/2006)
10.	Landfear, Scott M: 2 articles (07/2009 - 08/2006)

Related Diseases

1.	Pain (Aches) 11/30/2002 - "Intrathecal grafting of cells as biological pumps to deliver monoamines, endorphins, and/or trophic factors, has been shown to be effective in treating chronic pain both in experimental animals and in clinical trials. " Order ALL the reference details at left...
2.	Infection 04/01/1986 - "The possibilities in utilizing active transport permeases to direct drugs to the desired receptor are an obvious reality, and will undoubtedly lead to new methods for treating bacterial, fungal or even viral infections, and for improved ways of presenting anti-tumour agents. " 10/01/2003 - "Eukaryotic Nramp genes encode divalent metal ion permeases important for nutrition and resistance to microbial infection. " 12/01/2008 - "Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection." 01/01/1998 - "[Hepatocellular transport of bile acids and organic anions in infection and SIRS--evidence for different mechanisms for regulating membrane transport proteins]" 07/10/2009 - "Permeases belonging to the equilibrative nucleoside transporter family promote uptake of nucleosides and/or nucleobases into a wide range of eukaryotes and mediate the uptake of a variety of drugs used in the treatment of cancer, heart disease, AIDS, and parasitic infections. " Order ALL the reference details at left...
3.	Cholestasis 02/08/2005 - "Gene expression analysis of the BDL knockout animals demonstrated that, in response to cholestasis, PXR and CAR both repressed and induced the specific hepatic membrane transporters Oatp-c (organic anion transporting polypeptide C) and Oatp2 (Na+-dependent organic anion transporter 2), respectively. " 06/01/2003 - "Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. " 08/01/2002 - "OBJECTIVES: Rats with ethinyl estradiol-induced cholestasis have a decreased bile flow and a decreased expression of basolateral and canalicular hepatocyte membrane transporters. " 09/01/2008 - "Ischaemic cholestasis can be ascribed, at least partly, to hypoxia-induced disorders in the expression of hepatocytes biliary salts membrane transporters." 01/01/2003 - "This review summarizes the current knowledge of the role of bile acid in the canalicular bile secretion: its membrane transport in hepatocyte; molecular mechanisms and pathways of its regulatory effects on membrane transporters; the role of its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by hydrophobic bile acids; the possible mechanisms of protective effects of ursodeoxycholic acid in cholestatic impairment of the liver." Order ALL the reference details at left...
4.	Breast Neoplasms (Breast Cancer) 04/01/2005 - "Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member of ABC drug efflux membrane transporters. " 08/01/2008 - "Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-glycoprotein) and breast cancer resistant protein (BCRP, ABCG2) is protection against environmental toxins. " 10/01/2004 - "BACKGROUND & OBJECTIVE: Breast cancer resistance protein (BCRP), discovered in 1998, is a novel member of ATP-binding cassette (ABC) membrane transporters superfamily. " 11/01/2002 - "Two membrane transporters, the 17 amino acid (aa) oligopeptide penetratin derived from the homeodomain of Antennapedia (Ant) and an analogue of the basic domain of TAT (aa 47-57) (TAT-a) from HIV-1, were tested as carriers for a p53 C-terminal peptide (aa 361-382) into human breast cancer cells. " 08/01/2000 - "Multidrug resistance (MDR1) P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and breast cancer resistance protein (BCRP/MXR/ABCP) are members of the ATP-binding-cassette (ABC) superfamily of membrane transporters and are thought to function as energy-dependent efflux pumps of a variety of structurally diverse chemotherapeutic agents. " Order ALL the reference details at left...
5.	Necrosis 01/01/2003 - "This review summarizes the current knowledge of the role of bile acid in the canalicular bile secretion: its membrane transport in hepatocyte; molecular mechanisms and pathways of its regulatory effects on membrane transporters; the role of its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by hydrophobic bile acids; the possible mechanisms of protective effects of ursodeoxycholic acid in cholestatic impairment of the liver." 01/01/2006 - "However, a number of other phenomena, such as the selective inhibition and/or loss of various membrane transporters, enhancement of ion conductances, increased cytoplasmic concentration of calcium, deranged cytoskeleton and cell polarity, impaired endocytosis, swelling and fragmentation of mitochondria, increased expression of metallothionein, heat-shock and multidrug resistance proteins, loss of cell membrane integrity, as well as the damage of mitochondrial and genomic DNAs have been fragmentarily demonstrated for the action of some toxic metals, but their importance for the course of nephrotoxicity and the sequence of events in relation to oxidative stress, apoptosis, and necrosis have not been clearly established. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Endorphins
2.	Adenosine Triphosphate (ATP)
3.	Bile Acids and Salts (Bile Acids)
4.	Ursodeoxycholic Acid (Urso)
5.	Biological Markers (Surrogate Marker)
6.	Sulindac (Copal)
7.	Homocysteine
8.	Arsenic
9.	Antineoplastic Agents (Antineoplastics)
10.	P-Glycoprotein

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)

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