Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: Exposure to diesel exhaust enhanced infiltration of eosinophils and neutrophils in murine airways even 1 day after the challenge. An increment of goblet cells under the bronchial epithelium was followed by the recruitment of inflammatory cells. Furthermore, exposure to diesel exhaust combined with ovalbumin sensitization enhanced respiratory resistance and expression of IL-5 in lung tissue and IgG1 production but not IgE. However, diesel exhaust alone did not induce pathologic changes in mice. CONCLUSIONS:
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Authors | Y Miyabara, T Ichinose, H Takano, H B Lim, M Sagai |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 102
Issue 5
Pg. 805-12
(Nov 1998)
ISSN: 0091-6749 [Print] United States |
PMID | 9819298
(Publication Type: Journal Article)
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Chemical References |
- Vehicle Emissions
- Immunoglobulin E
- Ovalbumin
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Topics |
- Animals
- Antibody Specificity
- Asthma
(etiology, immunology, physiopathology)
- Bronchial Hyperreactivity
(etiology)
- Bronchoalveolar Lavage Fluid
(cytology)
- Immunoglobulin E
(biosynthesis, immunology)
- Male
- Mice
- Mice, Inbred ICR
- Ovalbumin
(pharmacology)
- Vehicle Emissions
(adverse effects)
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