Molecular approaches for the treatment of hemorrhagic fever virus infections.

Abstract

Viruses causing hemorrhagic fevers in man belong to the following virus groups: togavirus (Chikungunya), flavivirus (dengue, yellow fever, Kyasanur Forest disease, Omsk hemorrhagic fever), arenavirus (Argentinian hemorrhagic fever, Bolivian hemorrhagic fever, Lassa fever), filovirus (Ebola, Marburg), phlebovirus (Rift Valley fever), nairovirus (Crimian-Congo hemorrhagic fever) and hantavirus (hemorrhagic fever with renal syndrome, nephropathic epidemia). Hemorrhagic fever virus infections can be approached by different therapeutic strategies: (i) vaccination; (ii) administration of high-titered antibodies; and (iii) treatment with antiviral drugs. Depending on the molecular target of their interaction, antiviral agents could be classified as follows: IMP dehydrogenase inhibitors (i.e., ribavirin and its derivatives); OMP decarboxylase inhibitors (i.e., pyrazofurin); CTP synthetase inhibitors (i.e., cyclopentylcytosine and cyclopentenylcytosine); SAH hydrolase inhibitors (i.e., neplanocin A); polyanionic substances (i.e., sulfated polymers); interferon and immunomodulators.

• Authors: G Andrei, E De Clercq
• Journal: Antiviral research (Antiviral Res) Vol. 22 Issue 1 Pg. 45-75 (Sep 1993) ISSN: 0166-3542 [Print] Netherlands
• PMID: 8250543 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antiviral Agents

Topics

• Antiviral Agents (therapeutic use)
• Arenavirus
• Carbohydrate Sequence
• Filoviridae
• Flavivirus
• Orthohantavirus
• Hemorrhagic Fevers, Viral (drug therapy, microbiology, transmission)
• Humans
• Molecular Sequence Data
• Nairovirus
• Togaviridae