Rift Valley Fever

An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.

Also Known As:

Networked: 173 relevant articles (8 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dengue (Dengue Fever)
2.	Infection
3.	Venezuelan Equine Encephalomyelitis
4.	Yellow Fever
5.	Fever (Fevers)

Experts

1.	Bouloy, Michèle: 5 articles (10/2014 - 09/2008)
2.	Peters, C J: 5 articles (10/2013 - 12/2001)
3.	Ikegami, Tetsuro: 4 articles (01/2015 - 08/2006)
4.	Khairallah, Moncef: 4 articles (11/2013 - 10/2009)
5.	Makino, Shinji: 4 articles (10/2013 - 08/2006)
6.	Paweska, Janusz T: 3 articles (01/2015 - 11/2003)
7.	Pijlman, Gorben P: 2 articles (05/2015 - 07/2011)
8.	Boshra, Hani: 2 articles (01/2015 - 05/2013)
9.	Grobbelaar, Antoinette A: 2 articles (01/2015 - 11/2003)
10.	Babiuk, Shawn: 2 articles (01/2015 - 05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rift Valley Fever:

1.	VaccinesIBA 07/01/2012 - "Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. " 09/03/2014 - "Comparative efficacy of two next-generation Rift Valley fever vaccines." 05/14/2012 - "Efficacy of three candidate Rift Valley fever vaccines in sheep." 08/05/2011 - "Safety and efficacy of Rift Valley fever Smithburn and Clone 13 vaccines in calves." 09/01/1979 - "In a study of the response in cattle to a live and an inactivated Rift Valley fever (RVF) vaccine prepared from cell cultures infected with RVF virus, the effects of varying doses and combinations of these vaccines were compared. "
2.	DNA (Deoxyribonucleic Acid)IBA 01/01/2009 - "The appearance of Rift Valley Fever associated clinical signs were significantly decreased among the DNA vaccinated mice and further adjustment of this strategy may result in full protection against Rift Valley Fever." 01/01/2013 - "In this work, we evaluated the immunogenicity and protective efficacy of recombinant plasmid DNA and modified vaccinia virus Ankara (rMVA) vectored vaccines against Rift Valley fever in mice. " 11/01/1992 - "A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were isolated or synthesized and subsequently evaluated in cell culture against the RNA-containing flaviviruses (Japanese encephalitis, yellow fever, and dengue viruses), bunyaviruses (Punta Toro, sandfly fever, and Rift Valley fever viruses), alphavirus (Venezuelan equine encephalomyelitis virus), lentivirus (human immunodeficiency virus-type 1) and the DNA-containing vaccinia virus. "
3.	Chikungunya virus infectionIBA 01/01/2012 - "Extremes in climate conditions forced by the El Niño/Southern Oscillation (ENSO) lead to severe droughts or floods, ideal ecological conditions for disease vectors to emerge, and may result in epizootics and epidemics of Rift Valley fever and chikungunya. " 01/01/2012 - "Chikungunya and Rift Valley fever case locations were mapped to corresponding climate data anomalies to understand associations between specific anomaly patterns in ecological and climate variables and disease outbreak patterns through space and time. " 01/01/2012 - "Among the regions are Eastern and Southern Africa where outbreaks of chikungunya and Rift Valley fever occurred 2004-2009. " 01/01/2012 - "We analyze a variety of climate and satellite-derived vegetation measurements to explain the coupling between patterns of climate variability and disease outbreaks of Rift Valley fever and chikungunya. " 01/01/2012 - "Recent clusters of outbreaks of mosquito-borne diseases (Rift Valley fever and chikungunya) in Africa and parts of the Indian Ocean islands illustrate how interannual climate variability influences the changing risk patterns of disease outbreaks. "
4.	Ribavirin (Virazole)FDA LinkGeneric 11/01/1991 - "[The efficacy of immobilized liposomal preparations of ribamidil in experimental Rift Valley fever]." 01/29/2005 - "Ribavirin can be indicated in some cases such as the Rift Valley fever, but is formally contraindicated in West Nile encephalitis. " 03/01/1988 - "Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) was markedly inhibitory in vitro to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever and sandfly fever viruses. " 10/01/1984 - "Combinations of ribavirin and selenazofurin were synergistic against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, and Pichinde viruses, with fractional inhibitory concentrations of 0.1, 0.2, 0.4, 0.4, respectively, but showed additive effects against Korean hemorrhagic fever and Rift Valley fever viruses. " 10/01/1984 - "Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) were tested in vitro for activity against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, Rift Valley fever, Korean hemorrhagic fever, and Pichinde viruses. "
5.	AntibodiesIBA 08/01/2011 - "Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF) epidemic, to identify risk factors for interval seroconversion, and to monitor individuals previously exposed to RVFV in order to document the persistence of their anti-RVFV antibodies. " 01/01/2009 - "This study was carried out to clarify the possible role of pigs as intermediate host for Rift Valley Fever (RVF) virus through detection of antibodies to RVF in the sera of pigs and human contacts. " 12/01/2003 - "A retrospective study was undertaken to examine domestic ruminant sera for Rift Valley fever (RVF) virus antibodies. " 09/01/1996 - "Between 1986 and 1989, 2,255 sera collected from six domestic animal species in Nigeria were tested for antibodies to Rift Valley fever (RVF) virus. " 09/01/1996 - "Between 1985 and 1989, a total of 3,121 human sera collected from different population groups in six ecological zones of Nigeria were tested for the presence of antibodies to Rift Valley fever (RVF) virus by the haemagglutination-inhibition test. "
6.	Tilorone (Tilorone Hydrochloride)IBA 01/01/2012 - "The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). "
7.	ridostinIBA 01/01/2012 - "The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). "
8.	10-carboxymethyl-9-acridanoneIBA 01/01/2012 - "The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). "
9.	AntigensIBA 03/31/2007 - "Serodiagnosis of Rift Valley fever (RVF) currently relies on the use of live or inactivated whole virus as antigens. " 12/01/1996 - "The distribution of Rift Valley fever (RVF) viral antigen was studied by immunohistochemistry in the liver, spleen, prescapular lymph node, lungs and kidneys ot eight experimentally infected new-born lambs and in four new-born lambs that died of RVF during the 1974-75 RVF epidemic. " 11/01/1992 - "A sensitive but non-specific immunofluorescent antibody test and a specific enzyme-linked immunosorbent assay (ELISA) were used, with the following African phlebovirus antigens: Rift Valley fever (RVF), Arumowot, Gabek Forest, Gordil, Saint Floris and Odrenisrou. " 03/01/1989 - "Diagnosis of a human case of Rift Valley fever by immunoperoxidase demonstration of antigen in fixed liver tissue." 01/01/1989 - "Rapid diagnosis of Rift Valley fever: a comparison of methods for the direct detection of viral antigen in human sera."
10.	RNA (Ribonucleic Acid)IBA 10/09/2013 - "The safety and immunogenicity of an authentic recombinant (ar) of the live, attenuated MP-12 Rift Valley fever (RVF) vaccine virus with a large deletion of the NSm gene in the pre-Gn region of the M RNA segment (arMP-12ΔNSm21/384) was tested in 4-6 month old Bos taurus calves. " 01/07/2013 - "The safety and immunogenicity of two authentic recombinant (ar) Rift Valley fever (RVF) viruses, one with a deletion in the NSs region of the S RNA segment (arMP-12ΔNSs16/198) and the other with a large deletion of the NSm gene in the pre Gn region of the M RNA segment (arMP-12ΔNSm21/384) of the RVF MP-12 vaccine virus were tested in crossbred ewes at 30-50 days of gestation. " 10/01/1990 - "Reassortant viruses containing heterologous S and M genomic RNA segments were obtained from both mosquito and vertebrate hosts that had been coinfected with Egyptian and Senegalese strains of Rift Valley fever (RVF) virus. " 05/01/2007 - "A shared transcription termination signal on negative and ambisense RNA genome segments of Rift Valley fever, sandfly fever Sicilian, and Toscana viruses." 07/01/1992 - "Primer-extension sequencing of the RNA template of polio, dengue, Rift Valley fever, and Japanese encephalitis (JE) viruses has provided new information on their geographic distribution, origin, and evolution. "

Therapies and Procedures

1.	Subcutaneous Injections 06/01/1985 - "A Rift Valley fever vaccine trial: 2. Serological response to booster doses with a comparison of intradermal versus subcutaneous injection."
2.	Therapeutics 11/20/2012 - "Rift Valley fever and Toscana viruses are human pathogens for which no effective therapeutics exist. " 01/01/2015 - "Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them. "