The effects of brain natriuretic peptide-32 on electroconvulsive shock-induced amenesia in rats. The role of neurotransmitters.

Abstract

Partial amnesia was induced in rats by electroconvulsive shock (ECS) immediately after passive avoidance learning. This partial amnesia could be prevented by administering porcine brain natriuretic peptide-32 (pBNP-32) into the lateral brain ventricle. The effects of pretreatment with different receptor blockers (haloperidol, atropine, phenoxybenzamine, propranolol, naloxone, bicuculline and methysergide) on the pBNP-32-induced antiamnesia were investigated. In the doses selected, the blockers had no influence on the ECS-induced amnesia. Haloperidol, atropine, phenoxybenzamine and propranolol blocked the antiamnesic action of the peptide, while naloxone, bicuculline and methysergide were ineffective. These results suggest that pBNP-32 may influence learning processes and that the antiamnesic action of this peptide is mediated by dopaminergic, cholinergic alpha- and beta-adrenergic mediator systems.

• Authors: A Bidzseranova, J Varga, G Telegdy
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 232 Issue 2-3 Pg. 305-8 (Mar 02 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8096818 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Tissue Proteins
• Neurotransmitter Agents
• Receptors, Cell Surface
• Natriuretic Peptide, Brain
• brain natriuretic peptide, porcine

Topics

• Amnesia (physiopathology, prevention & control, psychology)
• Animals
• Avoidance Learning (drug effects)
• Brain Chemistry (drug effects)
• Electroshock
• Injections, Intraventricular
• Male
• Natriuretic Peptide, Brain
• Nerve Tissue Proteins (administration & dosage, antagonists & inhibitors, therapeutic use)
• Neurotransmitter Agents (physiology)
• Rats
• Rats, Inbred Strains
• Receptors, Cell Surface (antagonists & inhibitors)
• Swine