Haloperidol (Haldol)

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in MENTAL RETARDATION and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)

Also Known As:

Networked: 4192 relevant articles (342 outcomes, 747 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Citrome, Leslie: 22 articles (10/2014 - 02/2002)
2.	Lieberman, Jeffrey A: 20 articles (01/2013 - 02/2002)
3.	Kulkarni, Shrinivas K: 17 articles (02/2009 - 06/2002)
4.	Volavka, Jan: 16 articles (10/2014 - 02/2002)
5.	Czobor, Pal: 16 articles (07/2014 - 02/2002)
6.	Kane, John M: 15 articles (12/2015 - 05/2002)
7.	Crespo-Facorro, Benedicto: 13 articles (06/2013 - 08/2006)
8.	Bishnoi, Mahendra: 12 articles (01/2012 - 01/2007)
9.	Leucht, Stefan: 11 articles (11/2015 - 03/2004)
10.	Ohno, Yukihiro: 11 articles (04/2015 - 07/2008)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/01/2013 - "The typical antipsychotic haloperidol is a highly effective treatment for schizophrenia but its use is limited by a number of serious, and often irreversible, motor side effects. " 01/01/1978 - "In the double blind study with haloperidol, both substances were found to be highly effective in the treatment of psychotic syndromes belonging predominantly to the schizophrenia group. " 01/01/2010 - "Treatment with RLAI is suggested to result in improved QALYs combined with cost savings compared with haloperidol LAI among the Swedish, high-risk non-compliant schizophrenia patient population. " 07/04/2006 - "Haloperidol is a prototype of typical APDs, and the other three drugs are atypical APDs, which are effective in reducing negative symptoms and cognitive deficits of schizophrenia, cause less side effects, and are more tolerable compared to haloperidol. " 11/01/2013 - "Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. "
2.	Catalepsy 07/11/1985 - "Ablation of the frontal or parietal cortex led to a marked decrease in haloperidol catalepsy, whereas lesions of the occipital cortex, or of the olfactory bulbs did not affect catalepsy, when measured 3 weeks post lesion in all cases. " 02/15/2015 - "A significant reduction of the catalepsy response was seen in rats previously given haloperidol and receiving DBS at the IC. " 10/15/2008 - "In addition, compound 35 had good metabolic stability with a scaled intrinsic clearance of 3 mL/min/kg (HLM) and demonstrated efficacy in the haloperidol induced catalepsy model." 01/01/1984 - "Higher doses of haloperidol (1 and 5 mg/kg) produced significantly greater catalepsy in the hyperthyroid rats and significantly reduced catalepsy in the hypothyroid rats. " 01/01/1993 - "In contrast, haloperidol was found to be more effective in inducing catalepsy after i.v. (ED50 = 0.4 mumol/kg) than after i.p. "
3.	Delirium 03/01/2012 - "For elderly patients admitted to intensive care unit after noncardiac surgery, short-term prophylactic administration of low-dose intravenous haloperidol significantly decreased the incidence of postoperative delirium. " 05/01/2015 - "These results emphasize the need for more studies regarding the efficacy of haloperidol for treatment of delirium among older medical ICU patients and demonstrate the value of assessing nonintubated patients." 01/01/2015 - "In two small trials (total number of patients = 133), haloperidol did not appear to be effective in treating delirium. " 01/01/2007 - "Low dose haloperidol may be effective in decreasing the degree and duration of delirium in post-operative patients, compared with placebo. " 07/01/1995 - "Experience with continuous haloperidol infusions is growing, and it appears to be an effective method for control of severe agitation or delirium. "
4.	Bipolar Disorder (Mania) 01/01/2006 - "There is some evidence that haloperidol is an effective treatment for acute mania. " 06/01/2009 - "Recent studies have demonstrated clear evidence on the efficacy of haloperidol on the treatment of acute mania. " 01/01/2013 - "In Europe, haloperidol is still the reference substance used in clinical trials despite the fact that it is not officially indicated in the treatment of mania. " 01/01/2005 - "It is paradoxical to note that, in Europe, haloperidol is still the reference substance used in clinical trials despite the fact that it is not officially indicated in the treatment of mania. " 08/01/2001 - "In this study, the authors examined the relationship between steady-state haloperidol blood levels and clinical response in patients with acute psychotic mania. "
5.	Psychotic Disorders (Schizoaffective Disorder) 04/01/1997 - "The present study was undertaken with the aim to compare the efficacy of high and low oral doses of haloperidol in the treatment of acute and transient psychotic disorders. " 01/01/1987 - "Haloperidol, a butyrophenon, is widely used for the treatment of psychotic disorders in man. " 01/01/2015 - "Haloperidol is a neuroleptic drug used for a medication of various psychoses and deliria. " 01/01/2009 - "Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. " 06/01/2004 - "While haloperidol is still widely used in the treatment of psychoses, the optimal daily dose remains a topic of controversy, particularly in first-episode psychosis. "

Related Drugs and Biologics

1.	Risperidone (Risperdal Consta)
2.	olanzapine (Zyprexa)
3.	Antipsychotic Agents (Antipsychotics)
4.	quetiapine (Seroquel)
5.	aripiprazole (Abilify)
6.	Clozapine (Clozaril)
7.	Lithium
8.	Pimozide (Orap)
9.	ziprasidone (Geodon)
10.	sultopride (amisulpride)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	General Anesthesia
3.	Long-Term Care
4.	Ambulatory Surgical Procedures (Outpatient Surgery)
5.	Oral Administration