Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.) Miq. or Stemona japonica (Blume) Miq. (The plant name has been checked with http://www.theplantlist.org), of which multiple biological activities has been verified. However, whether it may alleviate pulmonary fibrosis via regulating ferroptosis mechanism has not been confirmed. AIM OF THE STUDY: MATERIALS AND METHODS: We validated the effects of tuberostemonine and ferroptosis on TGF-β1-induced proliferation of human lung fibroblast and bleomycin-induced pulmonary fibrosis in mice. In vitro, the ferroptosis effect of TGF-β1 on human lung fibroblast were examined and the activity of ɑ-SMA, collagen, hydroxyproline and ferrous ions in cells were also examined. In vivo, ferroptosis impacts respiratory function. Inflammatory manifestations, hydroxyproline, collagen activity and ferrous ions in the lung or blood were subject to evaluation. RESULTS: CONCLUSIONS:
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Authors | Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 318
Issue Pt B
Pg. 116983
(Jan 10 2024)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 37532076
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
- tuberostemonine
- Transforming Growth Factor beta1
- Glutamic Acid
- Hydroxyproline
- Collagen
- Bleomycin
- Ions
- SLC7A11 protein, human
- Amino Acid Transport System y+
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Topics |
- Mice
- Humans
- Animals
- Pulmonary Fibrosis
(chemically induced, drug therapy, metabolism)
- Transforming Growth Factor beta1
(metabolism)
- Glutamic Acid
- Hydroxyproline
- Ferroptosis
- Collagen
(metabolism)
- Bleomycin
- Ions
(adverse effects, metabolism)
- Amino Acid Transport System y+
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