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Bleomycin (Blenoxane)

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Also Known As:

Blenoxane; Almirall Brand of Bleomycin Sulfate; BLEO-cell; Bellon Brand of Bleomycin Sulfate; Blanoxan; Bleolem; Bleomicina; Bleomycin A(2); Bleomycin A2; Bleomycin B(2); Bleomycin B2; Bleomycin Sulfate; Bleomycins; Bleomycinum Mack; Bléomycine Bellon; Bristol-Myers Squibb Brand of Bleomycin Sulfate; Bull Brand of Bleomycin Sulfate; Lemery Brand of Bleomycin Sulfate; Lundbeck Brand of Bleomycin Sulfate; Mack Brand of Bleomycin Sulfate; cell pharm Brand of Bleomycin Sulfate; BLEO cell; BLEOcell; Bellon, Bléomycine; Bristol Myers Squibb Brand of Bleomycin Sulfate; Mack, Bleomycinum; Sulfate, Bleomycin

Networked: 6166 relevant articles (473 outcomes, 974 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Distler, Jörg H W: 38 articles (01/2016 - 01/2007)
2.	Distler, Oliver: 37 articles (01/2016 - 01/2007)
3.	Schett, Georg: 33 articles (01/2016 - 01/2007)
4.	Dees, Clara: 30 articles (09/2015 - 05/2008)
5.	Phan, Sem H: 29 articles (11/2015 - 01/2002)
6.	Beyer, Christian: 23 articles (09/2015 - 03/2011)
7.	Zerr, Pawel: 21 articles (01/2016 - 11/2010)
8.	Kaminski, Naftali: 20 articles (03/2015 - 04/2002)
9.	Akhmetshina, Alfiya: 19 articles (09/2012 - 05/2008)
10.	Engert, Andreas: 18 articles (08/2015 - 01/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 10/01/2015 - "In vivo FIZZ1 expression was significantly elevated in the murine bleomycin-induced dermal fibrosis model, which was associated with significant reduction in adipocyte marker gene expression and subcutaneous lipoatrophy. " 07/01/2014 - "Collectively, our findings strongly suggest that significant reduction of MC numbers does not affect skin wound healing and bleomycin-induced fibrosis in mice, and provide to our knowledge previously unreported insight in the long-debated contribution of MCs in skin regenerative processes. " 01/01/2009 - "Concomitantly, we observed a clear decrease in neutrophil infiltration and a significant reduction in the severity of bleomycin-induced lung fibrosis in mice treated with placenta-derived cells, irrespective of the source (allogeneic or xenogeneic) or delivery route. " 02/01/2005 - "The therapeutic efficacy of the bleomycins is limited by development of lung fibrosis. " 08/15/1989 - "Bleomycin (BLEO), an antitumor antibiotic effective against a variety of malignancies, has been associated classically with a pulmonary toxic reaction producing diffuse interstitial fibrosis. "
2.	Neoplasms (Cancer) 08/01/2013 - "Bleomycin is an antineoplastic drug that has recently been employed to treat haemangiomas, the most common vascular tumors of infancy, with very good results. " 01/01/2002 - "Bleomycin is a glycopeptide drug that exerts potent genotoxic potential and is highly effective in the treatment of certain cancers when used in combination therapy. " 12/01/2000 - "Bleomycin (BLM) has proven effective for the treatment of cancers, but the most serious dose-limiting side-effect is the development of pulmonary toxicity. " 01/01/1999 - "Clinically, the best results with radiosurgery were obtained with monocystic tumors amenable to stereotactic drainage and intracystic bleomycin treatment." 01/01/2003 - "Colon 26 tumors were eradicated in the mice given an intratumor (i.t.) injection of 500 microg bleomycin followed by treatment with electric fields ranging from 50 to 150 V/cm, with complete response rates ranging from 80% to 100%. "
3.	Hodgkin Disease (Hodgkin's Disease) 07/01/1997 - "This study summarized results of treatment of the extraperitoneal lymphatic nodes in patients with Hodgkin's disease with infusion of oily form of bleomycin into the lymphatic vessels. " 07/01/1997 - "[A trial of applying an oily suspension of bleomycin endolymphatically in patients with Hodgkin's disease of the extraperitoneal lymph nodes]." 04/11/2015 - "With respect to our predefined non-inferiority margin, bleomycin cannot be safely omitted either, and the standard of care for patients with early-stage favourable Hodgkin's lymphoma should remain ABVD followed by IFRT. " 01/01/2015 - "Bleomycin pulmonary toxicity in adult Saudi patients with Hodgkin's lymphoma." 10/01/2014 - "Late pulmonary complications of treating Hodgkin lymphoma: bleomycin-induced toxicity."
4.	Pulmonary Fibrosis (Hamman Rich Syndrome) 12/01/2015 - "MSCs are beneficial in rodent bleomycin pulmonary fibrosis models. " 12/01/2015 - "To shed light on the potential usefulness of MSCs for human disease, we aimed to systematically review the preclinical literature to determine if MSCs are beneficial in animal bleomycin pulmonary fibrosis models. " 08/01/2014 - "We investigated the efficacy of natural products with high anti-inflammatory activity, such as passion fruit peel extract (PFPE), in a mouse model of bleomycin-induced pulmonary fibrosis (PF). " 03/01/2012 - "This study developed novel sequences of siRNAs targeting the TGF-β1 gene and evaluated their therapeutic efficacy in two models of pulmonary fibrosis: a model induced by bleomycin and a novel model of the disease developed spontaneously in mice overexpressing the full length of human TGF-β1 in the lungs. " 12/01/2014 - "Intralesional bleomycin has been reported to be effective in microcystic LM; however, its use is limited by concerns about pulmonary fibrosis. "
5.	Lung Injury 10/01/2012 - "We have observed significant protective effects of Tβ4 on bleomycin-induced lung damage, the main outcomes being the halting of the inflammatory process and a substantial reduction of histological evidence of lung injury." 07/01/2011 - "In conclusion, targeting CCL3/MIP-1α by treatment with evasin-1 is beneficial in the context of bleomycin-induced lung injury, even when treatment is started after the fibrogenic insult. " 05/01/2005 - "The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of lung injury caused by bleomycin administration. " 12/01/2009 - "To investigate the contribution of mobilized autologous bone marrow-derived cells (BMDC) to lung repair after lung injury induced by bleomycin, and the mechanisms of any protective effects conferred by BMDC. " 08/01/2005 - "We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC) transfer. "

Related Drugs and Biologics

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2.	Vinblastine (Vinblastine Sulfate)
3.	Cisplatin (Platino)
4.	Vincristine (Oncovin)
5.	Etoposide (VP 16)
6.	Dacarbazine (DIC)
7.	Cyclophosphamide (Cytoxan)
8.	Prednisone (Sone)
9.	Procarbazine (Matulane)
10.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Radiotherapy
4.	Injections
5.	Sclerotherapy