The interaction between the kidney and the coagulation system greatly affects each other because of the abundant vessel distribution and blood perfusion in the kidney. Clinically, the risks of complicated
thrombosis and
bleeding have become important concerns in the treatment of nephropathies, especially
nephrotic syndrome, CKD, ESKD, and patients with nephropathy undergoing RRTs. Adverse effects of
anticoagulant or procoagulant
therapies in patients with nephropathy, especially anticoagulation-related nephropathy,
heparin-induced
thrombocytopenia, and
bleeding, seriously worsen the prognosis of patients, which have become challenges for clinicians. Over the decades, the interaction between the kidney and the coagulation system has been widely studied. However, the effects of the kidney on the coagulation system have not been systematically investigated. Although some coagulation-related
proteins and signaling pathways have been shown to improve coagulation abnormalities while avoiding additional kidney damage in certain
kidney diseases, their potential as anticoagulation targets in nephropathy requires further investigation. Here, we review the progression of research on the crosstalk between the coagulation system and
kidney diseases and systematically analyze the significance and shortcomings of previous studies to provide new sight into future research. In addition, we highlight the status of clinical treatment for coagulation disorder and nephropathy caused by each other, indicating guidance for the formulation of therapeutic strategies or
drug development.