In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus.

Abstract

Introduction:

Surveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.

Methods:

In this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin.

Results:

In vitro experiments showed that monolaurin inhibited viral replication by up to 80%, while in vivo studies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of inflammatory cytokines and promoted the release of interferon-γ, which enhanced the viral clearance activity of this type of MCFA.

Discussion:

Therefore, monolaurin is a potentially effective candidate for the treatment of SVV infection in pigs.

• Authors: Bo Su, Yingjie Wang, Shanqiu Jian, Huaqiao Tang, Huidan Deng, Ling Zhu, Xiaonan Zhao, Jian Liu, Huangzuo Cheng, Lina Zhang, Youjun Hu, Zhiwen Xu
• Journal: Frontiers in veterinary science (Front Vet Sci) Vol. 10 Pg. 980187 ( 2023) ISSN: 2297-1769 [Print] Switzerland
• PMID: 36777661 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Su, Wang, Jian, Tang, Deng, Zhu, Zhao, Liu, Cheng, Zhang, Hu and Xu.