Abstract | Background: Eosinophils are major effector cells of allergic disease and excellent markers of eosinophilic inflammation. Accurate and reliable biomarkers are helpful in the diagnosis, treatment, and control of allergic disease. Objective: Methods: Results: All subjects with allergic disease had elevated levels of serum EDN (median [interquartile range]: FA, 124.2 ng/mL [59.13-160.5 ng/mL]; AD, 110.8 ng/mL [57.52-167.9 ng/mL]; BA, 131.5 ng/mL [60.60-171.0 ng/mL]; AR, 91.32 ng/mL [46.16-145.0 ng/mL]) compared to HC (38.38 ng/mL [32.40-55.62 ng/mL]) (p < 0.0001). These elevated levels were consistent throughout the age range (6-12 years) of the healthy study subjects (p = 0.0679). EDN levels also correlated well with total immunoglobulin E (Rs = 0.5599, p < 0.0001). Looking at all individuals with an allergic disease, the area under the curve was 0.790. Conclusions: Direct measures of eosinophilic inflammation are needed for accurate diagnosis, treatment, and monitoring of allergic diseases. EDN may be a worthy biomarker of eosinophil activity and a useful screening tool for allergic diseases including FA, AD, BA, and AR.
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Authors | Chang-Keun Kim, Dong Yoon Kang, Zak Callaway, Kyoung Soo Kim, Eun Mi Kwon, Fumiya Yamaide, Taiji Nakano, Yoichi Suzuki, Yoichi Mashimo, Akira Hata, Yoshitaka Okamoto, Naoki Shimojo |
Journal | Asia Pacific allergy
(Asia Pac Allergy)
Vol. 12
Issue 3
Pg. e25
(Jul 2022)
ISSN: 2233-8276 [Print] Korea (South) |
PMID | 35966157
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. |