A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls.

Abstract

OBJECTIVES:

To explore the associations of environmental endocrine disruptors on precocious puberty in girls.

METHODS:

This was a case-control study in which 30 girls with precocious puberty and 46 age- and race-matched prepubertal females were enrolled. The concentrations of 10 environment endocrine disruptors (bisphenol A, bisphenol B, butylparaben, propylparaben, ethvlparaben, methylparaben, mono-butyl phthalate, mono-2-ethylhexyl phthalate, monoethyl phthalate, and monomethyl phthalate) in urine and 10 steroid hormones (dihydrotestosterone, corticosterone, hydrocortisone, 11-deoxycortisol, 17α-hydroxy progesterone, 4-androstene-3,17-dione, estrone, deoxycorticosterone, pregnenolone, and dehydroepiandrosterone) in serum were detected with the liquid chromatography-mass spectrometry (LC-MS).

RESULTS:

According to the Mann-Whitney U test, urinary levels of bisphenol A, monobutyl phthalate, and monomethyl phthalate were significantly higher in the precocious group than in the prepubertal group, and blood levels of hydrocortisone, 11-deoxycortisol, corticosterone, deoxycorticosterone, and pregnenolone were significantly lower in the precocious group than in the prepubertal group (p<0.05, VIP>1).

CONCLUSIONS:

Our findings confirm the association between phthalate exposure and the incidence of precocious puberty in girls. Control and reduction of children exposure to phthalate esters should be considered as a health priority.

• Authors: Fang Zhou, Zhenzhen Jin, Li Zhu, Fang Huang, Angzhi Ye, Chunguang Hou
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 35 Issue 8 Pg. 989-997 (Aug 26 2022) ISSN: 2191-0251 [Electronic] Germany
• PMID: 35692072 (Publication Type: Journal Article)
• Copyright: © 2022 Fang Zhou et al., published by De Gruyter, Berlin/Boston.

Chemical References

• Endocrine Disruptors
• Desoxycorticosterone
• Pregnenolone
• Corticosterone
• Cortodoxone
• Hydrocortisone

Topics

• Case-Control Studies
• Child
• Corticosterone (analysis)
• Cortodoxone (analysis)
• Desoxycorticosterone (analysis)
• Endocrine Disruptors (toxicity)
• Environmental Exposure (adverse effects, analysis)
• Female
• Humans
• Hydrocortisone
• Pregnenolone (analysis)
• Puberty, Precocious (chemically induced, epidemiology)