Coriolus versicolor is a natural drugs which has many pharmacological effects such as antitumor and enhanced immune activity. This paper studies the
therapeutic effect of Coriolus versicolor fruiting body (CVFB) on
streptozotocin (STZ)-induced Institute of
Cancer Research (ICR) diabetic mice, the STZ
solution was administered intraperitoneally at a dose of 150 mg/kg after fasting the mice, and ICR mice with fasting
blood glucose >16.7 mmol/l were selected for research.
Metformin was the positive control, and the dose of CVFB
powder (1000 mg/kg, 2000 mg/kg, and 4000 mg/kg) for 28 consecutive days by gavage. The serum and liver of mice were collected for relevant index content testing. The results showed that CVFB can control or reduce the fasting
blood glucose of mice and accelerate the rate of
glucose metabolism, can reduce the levels of total
cholesterol (T-CHO),
triglyceride (TG), and
high-density lipoprotein cholesterol (HDL-C) in mice, and regulate the abnormal symptoms of blood lipid metabolism commonly found in diabetes. It can increase the activity of
superoxide dismutase (SOD) and
glutathione peroxidase (GSH-Px)
antioxidant enzymes and enhance the ability of antioxidative stress in diabetic mice. In the H&E staining and apoptosis experiments of pancreatic tissue, CVFB can greatly reduce the inflammatory factors present in islets, increase the islet cells, and reduce the apoptotic rate caused by diabetes. All data confirmed the
therapeutic effect of CVFB on diabetic ICR mice. The present study provides a scientific basis for the development of drugs for the prevention and treatment of diabetes, it is of great significance to the in-depth study of Coriolus versicolor.