Abstract | BACKGROUND: Brain cortical areas are involved in processing of sensory, affective and cognitive aspects of pain. In the present study, microinjection effects of oxytocin and L-368,899 (an oxytocin receptor antagonist) into the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC) were investigated on sensory and affective aspects of neuropathic pain. METHODS:
Neuropathic pain was induced by partial sciatic nerve ligation (PSNL). Seven days later, right and left sides of S1 and ACC were surgically implanted with guide cannulas. Sensory (day 14) and affective (day 17) dimensions were recorded using von Frey filaments and place escape avoidance paradigm, respectively. The S1 and ACC oxytocin receptor protein expression were also determined. RESULTS: CONCLUSIONS: The results of the present study explained that the ACC and S1 oxytocin ameliorated sensory component of neuropathic pain, whereas affective component was attenuated only by ACC oxytocin. These effects might be related to the PSNL-increased oxytocin receptor expression in the S1 and ACC.
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Authors | Yasin Esmaeilou, Esmaeal Tamaddonfard, Amir Erfanparast, Farhad Soltanalinejad-Taghiabad |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 251
Pg. 113818
(07 01 2022)
ISSN: 1873-507X [Electronic] United States |
PMID | 35443199
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Receptors, Oxytocin
- Oxytocin
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Topics |
- Animals
- Gyrus Cinguli
(metabolism)
- Hyperalgesia
(drug therapy)
- Ligation
- Neuralgia
(drug therapy, metabolism)
- Oxytocin
(metabolism, pharmacology, therapeutic use)
- Rats
- Receptors, Oxytocin
(metabolism)
- Sciatic Nerve
- Somatosensory Cortex
(metabolism)
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